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Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial
BackgroundDespite evidence associating inflammatory biomarkers with worse outcomes in hospitalized adults with COVID-19, trials of immunomodulatory...
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Deconstructing neutrophil to lymphocyte ratio (NLR) in early breast cancer: lack of prognostic utility and biological correlates across tumor subtypes
PurposeThe prognostic utility and biological correlates of neutrophil to lymphocyte ratio (NLR), a potential biomarker of the balance between immune...
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Molecular profile of bladder cancer progression to clinically aggressive subtypes
Bladder cancer is a histologically and clinically heterogenous disease. Most bladder cancers are urothelial carcinomas, which frequently develop...
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Comprehensive multi-omics analysis of breast cancer reveals distinct long-term prognostic subtypes
Breast cancer (BC) is a leading cause of cancer-related death worldwide. The diverse nature and heterogeneous biology of BC pose challenges for...
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Multi-omics cluster defines the subtypes of CRC with distinct prognosis and tumor microenvironment
BackgroundColorectal cancer (CRC) is a complex malignancy characterized by diverse molecular profiles, clinical outcomes, and limited precision in...
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Mononuclear phagocyte system-related multi-omics features yield head and neck squamous cell carcinoma subtypes with distinct overall survival, drug, and immunotherapy responses
BackgroundRecent research reported that mononuclear phagocyte system (MPS) can contribute to immune defense but the classification of head and neck...
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Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes
Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To...
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Distinct subtypes of spatial brain metabolism patterns in Alzheimer’s disease identified by deep learning-based FDG PET clusters
PurposeAlzheimer’s disease (AD) is a heterogeneous disease that presents a broad spectrum of clinicopathologic profiles. To date, objective subty**...
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Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
Genomic analyses have redefined the molecular subgrou** of pediatric acute lymphoblastic leukemia (ALL). Molecular subgroups guide...
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Exploring subtypes of multiple sclerosis through unsupervised machine learning of automated fiber quantification
PurposeThis study aimed to subtype multiple sclerosis (MS) patients using unsupervised machine learning on white matter (WM) fiber tracts and...
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Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature
Previous studies have revealed that patients with hypertrophic cardiomyopathy (HCM) exhibit differences in symptom severity and prognosis, indicating...
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Identification of disulfidptosis-related subtypes, characterization of tumor microenvironment infiltration, and development of a prognosis model in colorectal cancer
BackgroundColorectal cancer is the second leading cause of cancer-related deaths, which imposes a significant societal burden. Regular screening and...
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Prognostic and immune infiltration features of disulfidptosis-related subtypes in breast cancer
Breast cancer (BC) is a prominent cause of cancer incidence and mortality around the world. Disulfidptosis, a type of cell death, can induce tumor...
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Stratification and prognostic evaluation of breast cancer subtypes defined by obesity-associated genes
ObjectiveBreast cancer was the most common type of cancer among women worldwide, significantly impacting their quality of life and survival rates....
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Risk factors analysis and survival prediction model establishment of patients with lung adenocarcinoma based on different pyroptosis-related gene subtypes
BackgroundLung adenocarcinoma (LUAD) is a common cancer with a poor prognosis. Pyroptosis is an important process in the development and progression...
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Comprehensive analysis and identification of subtypes and hub genes of high immune response in lung adenocarcinoma
BackgroundThe advent of immunotherapy targeting immune checkpoints has conferred significant clinical advantages to patients with lung adenocarcinoma...
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Characterization of stem cell subtypes and prognostic signature in hepatocellular carcinoma
BackgroundCancer stem cells (CSCs) were linked to cancer aggressiveness and poor prognosis in patients with hepatocellular carcinoma (HCC).
...
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Impact of Immune Cells on Stroke Limited to Specific Subtypes: Evidence from Mendelian Randomization Study
IntroductionStroke is one of the common diseases that pose a severe threat to human health, with immune cells playing a crucial role in its onset and...
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Proteo-genomic characterization of cirrhosis-associated liver cancers reveals potential subtypes and therapeutic targets
BackgroundThis study aimed to identify potential subtypes of hepatocellular carcinoma (HCC) associated with cirrhosis and to investigate key markers...
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Bioinformatics-led discovery of ferroptosis-associated diagnostic biomarkers and molecule subtypes for tuberculosis patients
BackgroundFerroptosis is closely associated with the pathophysiological processes of many diseases, such as infection, and is characterized by the...
