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Selection hub MicroRNAs as biomarkers in breast cancer stem cells in extracellular matrix using bioinformatics analyses
BackgroundBreast cancer is one of the most common cancers in women, and many people get it every year. The cancer stem cells are maybe crucial role...
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Role of necroptosis and immune infiltration in preeclampsia: novel insights from bioinformatics analyses
BackgroundPreeclampsia (PE) is a serious pregnancy complication that can adversely affect the mother and fetus. Necroptosis is a recently discovered...
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Bioinformatics in urology — molecular characterization of pathophysiology and response to treatment
The application of bioinformatics has revolutionized the practice of medicine in the past 20 years. From early studies that uncovered subtypes of...
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Identification of two potential immune-related biomarkers of Graves’ disease based on integrated bioinformatics analyses
BackgroundGraves’ disease (GD) is an autoimmune disease, the incidence of which is increasing yearly. GD requires long-life therapy. Therefore, the...
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Microrna-1224-5p Is a Potential Prognostic and Therapeutic Biomarker in Glioblastoma: Integrating Bioinformatics and Clinical Analyses
ObjectiveGlioblastoma (GBM) is the most common, invasive, and malignant primary brain tumor with a poor prognosis and high recurrence rate. It’s...
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Identification of the prognostic value of LACTB2 and its correlation with immune infiltrates in ovarian cancer by integrated bioinformatics analyses
Ovarian cancer (OC) is one of the most common reproductive tumors in women, whereas current treatment options are limited. β-lactamase-like-protein 2...
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Next-generation sequencing and bioinformatics in rare movement disorders
The ability to sequence entire exomes and genomes has revolutionized molecular testing in rare movement disorders, and genomic sequencing is becoming...
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Integrating network pharmacology, bioinformatics, and experimental validation to unveil the molecular targets and mechanisms of galangin for treating hepatocellular carcinoma
BackgroundGalangin, a flavonoid compound, is derived from Alpinia officinarum Hance. Previous studies have shown that galangin can inhibit the...
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Cross-sectional studies of the causal link between asthma and osteoporosis: insights from Mendelian randomization and bioinformatics analysis
SummaryThe study, using data from Chongqing, China, and employing Mendelian randomization along with bioinformatics, establishes a causal link...
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Applications of artificial intelligence and bioinformatics methodologies in the analysis of ocular biofluid markers: a sco** review
PurposeThis sco** review summarizes the applications of artificial intelligence (AI) and bioinformatics methodologies in analysis of ocular...
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Exploring the association between circRNA expression and pediatric obesity based on a case–control study and related bioinformatics analysis
ObjectiveOur present study utilized case–control research to explore the relationship between specific circRNAs and pediatric obesity through a...
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Bioinformatics integration reveals key genes associated with mitophagy in myocardial ischemia-reperfusion injury
BackgroundMyocardial ischemia is a prevalent cardiovascular disorder associated with significant morbidity and mortality. While prompt restoration of...
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Bioinformatics analysis of potential key genes and pathways in neonatal necrotizing enterocolitis
ObjectiveTo detect differentially expressed genes in patients with neonatal necrotizing enterocolitis (NEC) by bioinformatics methods and to provide...
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Effects and mechanisms of puerarin against neuroblastoma: insights from bioinformatics and in vitro experiments
BackgroundNeuroblastoma, a prevalent solid tumor in children, often manifests with hidden onset sites, rapid growth, and high metastatic potential....
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Bioinformatics-based identification of key candidate genes and signaling pathways in patients with Parkinson’s disease and obstructive sleep apnea
ObjectivesExisting evidence exhibits that obstructive sleep apnea (OSA) is a potential consequence of Parkinson’s disease (PD) or a contributor to PD...
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Identification and bioinformatics analysis of lncRNAs in serum of patients with ankylosing spondylitis
ObjectivesThe aim of this study was to explore the long non-coding RNA (lncRNA) expression profiles in serum of patients with ankylosing spondylitis...
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Bioinformatics Analysis Reveals Novel Differentially Expressed Genes Between Ectopic and Eutopic Endometrium in Women with Endometriosis
BackgroundEndometriosis is one of the chronic and prevalent diseases among women. There is limited knowledge about its pathophysiology at the...
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Bioinformatics analyses of gene expression profile identify key genes and functional pathways involved in cutaneous lupus erythematosus
BackgroundLupus erythematosus is an autoimmune disease that causes damage to multiple organs ranging from skin lesions to systemic manifestations....
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Identification of SMC2 and SMC4 as prognostic markers in breast cancer through bioinformatics analysis
BackgroundBreast cancer (BRCA) is one of the most common malignant tumors. The structural maintenance of chromosome (SMC) gene family has been shown...
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Exploring molecular mechanisms of intra-articular changes in osteonecrosis of femoral head using DIA proteomics and bioinformatics
PurposeThis study is aimed to delve into the crucial proteins associated with hormonal osteonecrosis of the femoral head (ONFH) and its...
