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Comparison of decision tree with common machine learning models for prediction of biguanide and sulfonylurea poisoning in the United States: an analysis of the National Poison Data System
BackgroundBiguanides and sulfonylurea are two classes of anti-diabetic medications that have commonly been prescribed all around the world. Diagnosis...
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Effects of first-line diabetes therapy with biguanides, sulphonylurea and thiazolidinediones on the differentiation, proliferation and apoptosis of islet cell populations
AimsMetformin, rosiglitazone and sulfonylureas enhance either insulin action or secretion and thus have been used extensively as early stage...
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A consensus statement from the Japan Diabetes Society (JDS): a proposed algorithm for pharmacotherapy in people with type 2 diabetes—2nd Edition (English version)
The Japan Diabetes Society (JDS) adopted a swee** decision to release consensus statements on relevant issues in diabetes management that require...
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Burden of Illness of Type 2 Diabetes Mellitus in the Kingdom of Saudi Arabia: A Five-Year Longitudinal Study
IntroductionType 2 diabetes mellitus (T2DM) is associated with huge clinical and economic burden in the Kingdom of Saudi Arabia (KSA) which can be...
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Use of diabetes medications in adults with T2D and CVD in Japan: secondary analysis of the CAPTURE study
IntroductionThe CAPTURE study estimated the global prevalence of established cardiovascular disease (CVD) and characterized the usage of...
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Prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy in Japanese patients with type 2 diabetes: the Japan Diabetes Complication and its Prevention Prospective study (JDCP study 10)
Aim/introductionThis study aims to investigate the prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy (DSPN) in...
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Role of sodium-glucose cotransporter-2 inhibitors in risk of chronic kidney disease among patients with type 2 diabetes mellitus
AimThis retrospective analysis aims to explore the risk of chronic kidney disease (CKD) among type 2 diabetes mellitus (DM) patients with different...
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Trends in antidiabetic drug use and expenditure in public hospitals in Northwest China, 2012-21: a case study of Gansu Province
BackgroundSince the twenty-first century, the prevalence of diabetes has risen globally year by year. In Gansu Province, an economically...
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Prescription drug usage as measure of comorbidity resolution after bariatric surgery: a population-based cohort study
BackgroundObesity is a chronic and progressive disease associated with significant morbidity, mortality, and health-care costs. Bariatric surgery is...
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Impact of Initial Treatment Policies on Long-term Complications and Costs in Japanese Patients with Type 2 Diabetes: A Real-World Database Study
IntroductionType 2 diabetes (T2D) represents a remarkable disease burden in Japan, and the cost-effectiveness of pharmacotherapy is an important...
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A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country
BackgroundSodium glucose co-transporter 2 inhibitors (SGLT2is) are a novel class of oral antidiabetic drugs. To date, there are no...
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Novel targets for potential therapeutic use in Diabetes mellitus
Future targets are a promising prospect to overcome the limitation of conventional and current approaches by providing secure and effective treatment...
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Diabetes of the Exocrine Pancreas: Implications for Pharmacological Management
Post-pancreatitis diabetes mellitus, pancreatic cancer-related diabetes, and cystic fibrosis-related diabetes are often underappreciated. As a...
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Phenformin increases early hematopoietic progenitors in the Jak2V617F murine model
Background. Myeloproliferative neoplasms (MPN) are disorders characterized by an alteration at the hematopoietic stem cell (HSC) level, where the JAK2 ...
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Use of Antihyperglycemic Drugs and Risk of Cancer in Patients with Diabetes
Purpose of ReviewDiabetes is associated with an increased risk for several types of cancer. Therefore, use of antihyperglycemic medications to lower...
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A ten-year study of anti-diabetic drugs utilization in Iran
ObjectivesAccording to the world health organization (WHO), by the year 2030 diabetes will become the world’s seventh leading cause of death. This...
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Risk Factors Associated with COVID-19 Hospitalization and Mortality: A Large Claims-Based Analysis Among People with Type 2 Diabetes Mellitus in the United States
IntroductionDiabetes has been identified as a high-risk comorbidity for COVID-19 hospitalization. We evaluated additional risk factors for COVID-19...
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A novel biguanide (IM1761065) inhibits bioenergetics of glioblastoma tumorspheres
PurposeGlioblastoma (GBM) is a rapidly growing tumor in the central nervous system with altered metabolism. Depleting the bioenergetics of tumors...
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SMAD4 loss limits the vulnerability of pancreatic cancer cells to complex I inhibition via promotion of mitophagy
Pancreatic cancer is one of the deadliest forms of cancer, which is attributed to lack of effective treatment options and drug resistance....
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Real-World Study on Effectiveness of Insulin Glargine U300 After Oral Antidiabetic Drug Failure in Patients with Type 2 Diabetes in the Gulf Region
IntroductionThe effectiveness and safety of long-acting insulin glargine U300 (Gla-300), in patients with type 2 diabetes mellitus (T2DM) requiring...
