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The Blood-Brain Barrier Methods and Protocols
This detailed volume features techniques to explore the complex interface that separates the systemic circulation from the central nervous system,...
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Barrier Dysfunction in Eosinophilic Esophagitis
Purpose of ReviewCompelling evidence over the past decade supports the central role of epithelial barrier dysfunction in the pathophysiology of...
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Globale Umweltveränderungen und die „epithelial barrier hypothesis“
BackgroundThe global burden of noncommunicable diseases (NCD) has seen a strong increase in recent decades and attributable to the influence of...
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Blood–labyrinth barrier breakdown in Meniere’s disease
ObjectiveWe compared the signal intensity ratio (SIR) of the cochlear basal turn between Meniere's disease and healthy controls to investigate...
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Intestinal Barrier Dysfunction in Inflammatory Bowel Disease: Underpinning Pathogenesis and Therapeutics
The intestinal barrier is composed of several essential elements including luminal enzymes, bile acids, water layer, epithelial layer, and enterocyte...
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Gut Barrier Dysfunction and Bacterial Lipopolysaccharides in Colorectal Cancer
BackgroundInflammation is known to be an essential driver of various types of cancer. An increasing number of studies have suggested that the...
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Role of mucosal immunity and epithelial–vascular barrier in modulating gut homeostasis
The intestinal mucosa represents the most extensive human barrier having a defense function against microbial and food antigens. This barrier is...
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Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability
As the most prescribed psychotropic drugs in current medical practice, antidepressant drugs (ADs) of the selective serotonin reuptake inhibitor...
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Rifaximin Prevents Intestinal Barrier Dysfunction and Alleviates Liver Injury in MCT-induced HSOS Mice
ObjectiveRifaximin is an effective component of treatment strategies for liver and intestinal diseases. However, the efficacy of rifaximin in hepatic...
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The role of gut barrier dysfunction in postoperative complications in liver transplantation: pathophysiological and therapeutic considerations
PurposeGut barrier dysfunction is a pivotal pathophysiological alteration in cirrhosis and end-stage liver disease, which is further aggravated...
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Strategies to Improve Drug Delivery Across the Blood–Brain Barrier for Glioblastoma
Purpose of ReviewGlioblastoma remains resistant to most conventional treatments. Despite scientific advances in the past three decades, there has...
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Impaired skin barrier and allergic sensitization in 16-year-old adolescents
BackgroundTransepidermal water loss (TEWL) has been used to measure skin barrier function and has been associated with atopic dermatitis and allergic...
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Decreasing respiratory device-related pressure injuries in the NICU using 3D printed barrier templates
ObjectiveUse of non-invasive ventilation (NIV) in very low birthweight infants to decrease the incidence of bronchopulmonary dysplasia can also lead...
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Manometric esophagogastric junction barrier metrics as predictors of gastroesophageal reflux
BackgroundHigh-resolution manometry (HRM) tools, like esophagogastric junction contractile integral (EGJ-CI), assess EGJ barrier function.
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The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However,...
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Total flavonoids of Astragalus protects glomerular filtration barrier in diabetic kidney disease
BackgroundDiabetic kidney disease (DKD) is a prevalent complication of diabetes and the leading cause of end-stage renal disease. Recent evidence...
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LuQi Formula relieves ventricular remodeling through improvement of HIF-1α-mediated intestinal barrier integrity
BackgroundVentricular remodeling is the adaptive process in which the heart undergoes changes due to stress, leading to heart failure (HF). The...
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Medical mistrust as a barrier to HIV prevention and care
Medical mistrust is fueled by conspiracy theories and histories of healthcare systems abuse and is a known determinant of health outcomes in minority...
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Gut barrier dysfunction and the risk of ICU-acquired bacteremia- a case–control study
BackgroundImpaired intestinal barrier function can enable passage of enteric microorganisms into the bloodstream and lead to nosocomial bloodstream...
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Allergies Come Clean: The Role of Detergents in Epithelial Barrier Dysfunction
Purpose of ReviewThe prevalence and incidence of allergic disease have been rising in Westernized countries since the twentieth century....
