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Polymorphism in BACH2 gene is a marker of polyglandular autoimmunity
PurposeGenetically predisposed individuals may develop several autoimmune diseases—autoimmune polyendocrine syndromes (APS). APS types 2–4, are...
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A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML
Relapse is a major challenge to therapeutic success in acute myeloid leukemia (AML) and can be partly associated with heterogeneous leukemic stem...
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Whole genome sequencing identifies variants associated with sarcoidosis in a family with a high prevalence of sarcoidosis
ObjectiveWe studied genetic risk factors associated with sarcoidosis within a family with a high prevalence of this disease.
MethodsWe studied 41...
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Interferons are key cytokines acting on pancreatic islets in type 1 diabetes
Aims/hypothesisThe proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may contribute to innate and adaptive immune responses during insulitis in...
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The genetics of Graves’ disease
Graves’ disease (GD) is the commonest cause of hyperthyroidism and has a strong female preponderance. Everyday clinical practice suggests strong...
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Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
T cell differentiation is a highly regulated, multi-step process necessary for the progressive establishment of effector functions, immunological...
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Tip** the balance in autoimmunity: are regulatory t cells the cause, the cure, or both?
Regulatory T cells (Tregs) are a specialized subgroup of T-cell lymphocytes that is crucial for maintaining immune homeostasis and preventing...
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piggyBac-transposon-mediated CAR-T cells for the treatment of hematological and solid malignancies
Since the introduction of the use of chimeric antigen receptor T-cell therapy (CAR-T therapy) dramatically changed the therapeutic strategy for B...
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Disruption to the FOXO-PRDM1 axis resulting from deletions of chromosome 6 in acute lymphoblastic leukaemia
A common problem in the study of human malignancy is the elucidation of cancer driver mechanisms associated with recurrent deletion of regions...
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Heme as a differentiation-regulatory transcriptional cofactor
The hematopoietic transcription factor GATA1 induces heme accumulation during erythropoiesis by directly activating genes mediating heme...
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Genetics of ANCA-associated vasculitis: role in pathogenesis, classification and management
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) comprises granulomatosis with polyangiitis (GPA), microscopic polyangiitis...
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Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD)
BackgroundPatients with non-alcoholic fatty liver disease (NAFLD) may be more susceptible to coronavirus disease 2019 (COVID-19) and even more likely...
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The genetics of autoimmune Addison disease: past, present and future
Autoimmune Addison disease is an endocrinopathy that is fatal if not diagnosed and treated in a timely manner. Its rarity has hampered unbiased...
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Monocyte and macrophage function in respiratory viral infections
Pulmonary macrophages, such as tissue-resident alveolar and interstitial macrophages and recruited monocyte-derived macrophages, are the major...
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Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death
Aims/hypothesisTNF-α plays a role in pancreatic beta cell loss in type 1 diabetes mellitus. In clinical interventions, TNF-α inhibition preserves...
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Exploiting E3 ubiquitin ligases to reeducate the tumor microenvironment for cancer therapy
Tumor development relies on a complex and aberrant tissue environment in which cancer cells receive the necessary nutrients for growth, survive...
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The emerging roles of SUMOylation in the tumor microenvironment and therapeutic implications
Tumor initiation, progression, and response to therapies depend to a great extent on interactions between malignant cells and the tumor...
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Learning from Persistent Viremia: Mechanisms and Implications for Clinical Care and HIV-1 Cure
Purpose of ReviewIn this review, we discuss what persistent viremia has taught us about the biology of the HIV-1 reservoir during antiretroviral...
