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Outcomes of BRCA pre-implantation genetic testing according to the parental mutation origin: a cohort study
BackgroundThe process of gamete formation and early embryonic development involves rapid DNA replication, chromosome segregation and cell division....
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Prevalence of Germline Pathogenic BRCA mutations in women with High grade Serous ovarian cancers
IntroductionOvarian cancer is the most lethal of all gynaecological malignancies. These malignancies are known to harbour mutations in BRCA genes....
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BRCA, infertility, and fertility preservation: a review for counseling
BRCA mutations as a triggering factor in breast cancer have been reported to result in fertility problems and oocyte aging in young patients with...
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Left ventricular global longitudinal strain is worse in BRCA mutation positive breast cancer patients prior to cancer treatment and premature menopause
PurposeBreast cancer patients with mutations in human tumor suppressor genes BRCA1 and BRCA2 are at higher risk of cardiovascular disease (CVD) than...
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Clinical breast exam contribution to breast cancer diagnosis in BRCA mutation carriers vs. average to intermediate risk women
PurposeThe contribution of clinical breast exam (CBE) to breast cancer diagnosis in average risk women undergoing regular screening mammography is...
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Development and validation of ultrasound-based radiomics model to predict germline BRCA mutations in patients with breast cancer
BackgroundIdentifying breast cancer (BC) patients with germline breast cancer susceptibility gene (g BRCA ) mutation is important. The current...
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Molecular characteristics of Asian male BRCA-related cancers
PurposeGermline mutations of BRCA1 or BRCA2 predispose men to develop various cancers, including breast cancers and prostate cancers. Male breast...
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Aromatase inhibitors and contralateral breast cancer in BRCA mutation carriers
BackgroundDeleterious BRCA mutations confer a significant lifetime risk of breast cancer (BC) as well as contralateral BC (CBC) in patients who do...
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Olaparib enhances sensitization of BRCA-proficient breast cancer cells to x-rays and protons
PurposeThis study aimed to compare the radiosensitizing effect of the PARP inhibitor, Olaparib, between proton and X-rays irradiations in...
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Risk of endometrial cancer after RRSO in BRCA 1/2 carriers: a multicentre cohort study
ObjectiveTo know the risk of endometrial cancer (EC) in a population of women with BRCA 1/2 pathogenic or likely pathogenic variants after...
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Distinct breast cancer phenotypes in BRCA 1/2 carriers based on ER status
PurposeBRCA1/2 genes are the two main genes associated with hereditary breast cancers (BC). In the present study, we explore clinical and molecular...
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Down-regulation of FA-BRCA Pathway in Cervical Carcinoma Gradually Reversed During the Development of Chemo-tolerance: Clinical Implications
Cervical cancer is one of the leading causes of cancer death among females, worldwide. The contributory role of different cellular pathways in the...
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Convergent evolution of BRCA2 reversion mutations under therapeutic pressure by PARP inhibition and platinum chemotherapy
Reversion mutations that restore wild-type function of the BRCA gene have been described as a key mechanism of resistance to Poly(ADP-ribose)...
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Satisfaction and Well-Being After Contralateral Prophylactic Mastectomy Among BRCA Mutation Carriers and Noncarriers: A Longitudinal Analysis of BREAST-Q Domains
IntroductionContralateral prophylactic mastectomy (CPM) is recommended for BRCA mutation carriers; its use in noncarriers relies on patient choice....
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Neoadjuvant talazoparib in patients with germline BRCA1/2 mutation-positive, early-stage triple-negative breast cancer: exploration of tumor BRCA mutational status
BackgroundTalazoparib monotherapy in patients with germline BRCA -mutated, early-stage triple-negative breast cancer (TNBC) showed activity in the...
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Providers’ perspectives on the reproductive decision-making of BRCA-positive women
BackgroundReproductive decision-making is difficult for BRCA-positive women. Our objective was to assess the complexities of decision-making and...
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Hormone replacement therapy in BRCA mutation carriers: how shall we do no harm?
Women with a BRCA mutation have an increased risk of develo** breast and ovarian cancer. Bilateral sal**o-oophorectomy is the only effective...
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Impact of lower co-payments on risk-reducing sal**o-oophorectomy and BRCA testing in Japan
BackgroundIn April 2020, insurance coverage for risk-reducing sal**o-oophorectomy (RRSO) for breast cancer patients with hereditary breast and...
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The impact of germline BRCA pathogenic variants in locally advanced, triple negative breast cancer treated with platinum-based neoadjuvant chemotherapy
BackgroundWhether germline BRCA (gBRCA) pathogenic variants (PV) affect prognosis of women with triple negative breast cancer (TNBC) and whether it...
