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BMP7 alleviates trigeminal neuralgia by reducing oligodendrocyte apoptosis and demyelination
BackgroundBMP7 has been shown to have neuroprotective effects and to alleviate demyelination. However, its role in trigeminal neuralgia (TN) has not...
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CircSMAD4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving miR-377-3p-mediated BMP7 inhibition
BackgroundDiabetic nephropathy (DN) is a common complication of diabetes mellitus. Accumulating studies suggest that the deregulation of circular RNA...
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FGD5-AS1 facilitates the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells via targeting the miR-506-3p/BMP7 axis
BackgroundOsteoporosis is a systemic disease characterized by impaired bone formation, increased bone resorption, and brittle bone fractures. The...
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BMP7 overexpression in adipose tissue induces white adipogenesis and improves insulin sensitivity in ob/ob mice
Background/objectivesDuring obesity, hypertrophic enlargement of white adipose tissue (WAT) promotes ectopic lipid deposition and development of...
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The local concentration of Ca2+ correlates with BMP7 expression and osseointegration in patients with total hip arthroplasty
BackgroundA successful osseointegration of total hip arthroplasty (THA) relies on the interplay of implant surface and bone marrow microenvironment....
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Expression Analysis of Early Metastatic Seeding of Colorectal Cancer
BackgroundDistant metastasis is the leading cause of death in patients with colorectal cancer (CRC). Tumor dissemination for metastasis formation...
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Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant
Despite intense research and clinical efforts, patients affected by advanced colorectal cancer (CRC) have still a poor prognosis. The discovery of...
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Huangqi decoction ameliorates kidney injury in db/db mice by regulating the BMP/Smad signaling pathway
PurposeThis study aims to investigate the mechanism underlying the beneficial effects of Huangqi decoction (HQD) on Diabetic kidney disease (DKD) in...
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AR cooperates with SMAD4 to maintain skeletal muscle homeostasis
Androgens and androgen-related molecules exert a plethora of functions across different tissues, mainly through binding to the transcription factor...
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Bone morphogenetic protein induces bone invasion of melanoma by epithelial–mesenchymal transition via the Smad1/5 signaling pathway
Oral malignant melanoma, which frequently invades the hard palate or maxillary bone, is extremely rare and has a poor prognosis. Bone morphogenetic...
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Transcriptome-guided resolution of tumor microenvironment interactions in pheochromocytoma and paraganglioma subtypes
BackgroundPheochromocytomas and paragangliomas (PCPG) are rare catecholamine-secreting endocrine tumors deriving from chromaffin cells of the...
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Sirenomelia or mermaid syndrome with a cleft lip in a Tanzanian newborn: a case report
BackgroundSirenomelia or sirenomelia sequence, also known as mermaid syndrome, is a rare congenital anomaly involving the caudal region of the body....
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The extracts of osteoblast developed from adipose-derived stem cell and its role in osteogenesis
Cell-based therapy has become an achievable choice in regenerative medicines, particularly for musculoskeletal disorders. Adipose-derived stem cells...
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An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications
Adipose tissue, including white adipose tissue (WAT), brown adipose tissue (BAT), and beige adipose tissue, is vital in modulating whole-body energy...
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The brain–bone axis: unraveling the complex interplay between the central nervous system and skeletal metabolism
The brain–bone axis has emerged as a captivating field of research, unveiling the intricate bidirectional communication between the central nervous...
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Identification of immune-related signature with prognosis in children with stage 4 and 4S neuroblastoma
ObjectiveSpontaneous regression of tumors is an attractive phenomenon that most commonly occurs in stage 4S neuroblastoma (NB). However, the...
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Progress on the Role of Estrogen and Progesterone Signaling in Mouse Embryo Implantation and Decidualization
Embryo implantation and decidualization are key steps in establishing a successful pregnancy. Defects in embryo implantation and decidualization can...
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Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma
ObjectiveLung squamous cell carcinoma (LUSC) is associated with a low survival rate. Evidence suggests that bone morphogenetic proteins (BMPs) and...
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Pulmonary hypertension and chronic kidney disease: prevalence, pathophysiology and outcomes
Pulmonary hypertension (PH) is common in patients with chronic kidney disease (CKD) or kidney failure, with an estimated prevalence of up to 78% in...
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Regulation of epithelial-mesenchymal transition in retinal pigment epithelium and its associated cellular signaling cascades: an updated review
BackgroundThe epithelial-mesenchymal transition (EMT) affects the retinal pigment epithelium's natural homeostasis. According to observations from...
