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B-Lymphozyten und Plasmazellen als Treiber rheumatischer Erkrankungen
Various research groups at the German Rheumatism Research Center in Berlin, in close cooperation with the Department of Rheumatology and Clinical...
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Die Rolle der B-Lymphozyten bei Patient*innen mit systemischem Lupus erythematodes
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic relapsing courses and a wide spectrum of clinical presentations....
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Warum die Regeneration von immunologischer Toleranz durch Impfen schwierig ist
Autoimmunity, including that involved in chronic inflammatory rheumatic diseases, seems to be the price we have to pay for our efficient immune...
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Parkinson- und Alzheimer-Erkrankung als Systemerkrankungen
BackgroundParkinson’s and Alzheimer’s disease (PD/AD) are characterized by cellular pathological changes that precede clinical manifestation and...
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Neue und zukünftige Therapieansätze in der Behandlung der allergischen Konjunktivitis
BackgroundIn severe and recurrent ocular allergies conventional ophthalmic drugs can reach their limits, especially in chronic forms. The first novel...
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Tumor-Wirtszellen-Interaktion im Mikromilieu: neue Angriffspunkte für die Therapie?
BackgroundPrimary brain tumors and metastases in the central nervous system (CNS) are characterized by their unique microenvironment, which interacts...
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Klassifikation der Hodgkin-Lymphome und verwandter Entitäten
Two new classifications were recently released: the 5th edition of the WHO classification of hematolymphoid tumors and the International Consensus...
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Molekularpathologie und Biomarker des Melanoms
Malignant melanoma is one of the most aggressive malignant skin tumors. Molecularly, melanoma is characterized by a high mutational burden and shows...
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Masquerade/okuläres Lymphom
Interocular lymphomas are still an extremely complex topic in terms of their genesis as well as their diagnosis and treatment. Vitreoretinal...
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Infektionen bei Nierentransplantation
BackgroundKidney transplant recipients have a significantly increased risk of infections, which can threaten both health and transplant function....
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Letale lymphozytäre Myokarditis – eine unterschätzte Diagnose im Säuglings- und Kindesalter?
In the past, histological diagnosis of (post-)viral myocarditis was based on the so-called Dallas criteria, which have been criticized because of...
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Arzneitherapie der rheumatoiden Arthritis – wo stehen Biologika und neue synthetische Basistherapeutika heute?
Biologics and Janus kinase (JAK) inhibitors play an important role in the treatment of rheumatoid arthritis. As new therapeutic developments have...
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3D/4D strategische Lymphknotendiagnostik
BackgroundLymph-node diagnostics is performed using thin sections, with help of immunohistochemistry by light microscopy and supplemented by...
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Pneumokokkenimpfung im Säuglings- und im Kleinkindalter
Streptococcus pneumoniae causes various childhood diseases. Invasive pneumococcal diseases (IPD) are rare. They mainly affect infants and toddlers and...
