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Serum autotaxin is a prognostic indicator of liver-related events in patients with non-alcoholic fatty liver disease
BackgroundCirculating autotaxin (ATX) levels have been reported to correlate with liver inflammation activity and liver fibrosis severity in patients...
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Autotaxin inhibition attenuates the aortic valve calcification by suppressing inflammation-driven fibro-calcific remodeling of valvular interstitial cells
BackgroundPatients with fibro-calcific aortic valve disease (FCAVD) have lipid depositions in their aortic valve that engender a proinflammatory...
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Different Profiles of the Triad of Lysophosphatidylcholine, Lysophosphatidic Acid, and Autotaxin in Patients with Neuropathic Pain Diseases: a Preliminary Observational Study
The mechanisms underlying neuropathic pain remain unclear. Lysophosphatidic acid (LPA) is a bioactive phospholipid derived mainly from...
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Autotaxin is a potential predictive marker for the development of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation
Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a life-threatening complication after allogeneic hematopoietic cell...
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A role for bronchial epithelial autotaxin in ventilator-induced lung injury
BackgroundThe pathophysiology of acute respiratory distress syndrome (ARDS) may eventually result in heterogeneous lung collapse and edema-flooded...
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Autotaxin levels in serum and bronchoalveolar lavage fluid are associated with inflammatory and fibrotic biomarkers and the clinical outcome in patients with acute respiratory distress syndrome
BackgroundAutotaxin (ATX) is a secreted glycoprotein that is widely present in extracellular biological fluids and has been implicated in many...
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The impact of achieving a sustained virological response with direct-acting antivirals on serum autotaxin levels in chronic hepatitis C patients
BackgroundAutotaxin (ATX) is an emerging biomarker for liver fibrosis. Achievement of sustained virological response (SVR) by direct-acting...
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Serum autotaxin levels in responders to HCV treatment by direct-acting antivirals
BackgroundHepatitis C virus (HCV) infection is considered one of the main causes of chronic liver disease around the world. Liver biopsy has been...
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Prognostic value of serum autotaxin in liver cirrhosis and prediction of hepatocellular carcinoma
BackgroundAutotaxin is a lysophospholipase D related to liver fibrosis; its clinical role in liver cirrhosis is still unknown or limited. In this...
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Clinical Usefulness of Serum Autotaxin for Early Prediction of Relapse in Male Patients with Type 1 Autoimmune Pancreatitis
BackgroundSerum IgG4 level is a useful diagnostic marker for autoimmune pancreatitis (AIP), but it is difficult to use to predict relapse.
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Pruritus in patients with chronic liver disease and serum autotaxin levels in patients with primary biliary cholangitis
BackgroundPruritus is a common symptom seen in patients with chronic liver disease. However, frequency and severity of pruritus in patients with...
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Pemafibrate improves liver dysfunction and non-invasive surrogates for liver fibrosis in patients with non-alcoholic fatty liver disease with hypertriglyceridemia: a multicenter study
BackgroundThis retrospective, multicenter study evaluated the effect of pemafibrate treatment on liver function and fibrosis by liver function tests...
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Cholestatic Itch: Our Current Understanding of Pathophysiology and Treatments
Hepatic pruritus is common in liver conditions, including cholestasis and nonalcoholic fatty liver disease. The pruritus can be severe enough to...
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CREB-dependent LPA-induced signaling initiates a pro-fibrotic feedback loop between small airway basal cells and fibroblasts
BackgroundLysophosphatidic acid (LPA), generated extracellularly by the action of autotaxin and phospholipase A2, functions through LPA receptors...
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Altered cortical synaptic lipid signaling leads to intermediate phenotypes of mental disorders
Excitation/inhibition (E/I) balance plays important roles in mental disorders. Bioactive phospholipids like lysophosphatidic acid (LPA) are...
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LPA1 receptors in the lateral habenula regulate negative affective states associated with alcohol withdrawal
The role of lysophosphatidic acid (LPA) signaling in psychiatric disorders and drug abuse is significant. LPA receptors are widely expressed in the...
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Population Pharmacokinetic and Pharmacodynamic Analysis of GLPG1690, an Autotaxin Inhibitor, in Healthy Volunteers and Patients with Idiopathic Pulmonary Fibrosis
Background and ObjectivesGLPG1690 is an autotaxin inhibitor in development for the treatment of idiopathic pulmonary fibrosis. Several publications...
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Neue Therapieverfahren für die idiopathische Lungenfibrose am Horizont
BackgroundIdiopathic pulmonary fibrosis (IPF) is a fatal age-related lung disease with limited treatment options.
ObjectiveThis article gives an...
