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Atypical lobular hyperplasia: what we need to know
Atypical lobular hyperplasia (ALH) is defined as an epithelial proliferation that does not meet the qualitative or quantitative abnormalities to be...
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Upgrade Rate and Long-term Outcomes of Lobular Neoplasia
Purpose of ReviewLobular neoplasia is a risk factor for breast cancer development, but its management remains controversial as upgrade rates differ...
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Atypical Lobular Hyperplasia and Classic Lobular Carcinoma In Situ Can Be Safely Managed Without Surgical Excision
BackgroundBased on modern series demonstrating low upgrade rates for pure lobular neoplasia (LN) diagnosed on core needle biopsy (CNB), our...
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De-escalation of Surgical Intervention and Contemporary Management Recommendations for Lobular Neoplasia, Atypical Ductal Hyperplasia, and Ductal Carcinoma In Situ
Purpose of ReviewIn which patients is it oncologically safe to offer active surveillance instead of surgery for DCIS or a benign breast lesion with...
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Risk of Lobular Neoplasia Upgrade with Synchronous Carcinoma
BackgroundAtypical lobular hyperplasia (ALH) and classic lobular carcinoma in situ encompass a spectrum of proliferative lesions known as lobular...
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The Influence of Body Mass Index on the Histopathology and Outcomes of Patients Diagnosed with Atypical Breast Lesions
BackgroundMultiple studies have demonstrated a link between obesity and breast cancer; however, the potential association between obesity and...
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The morphologic spectrum of lobular carcinoma in situ (LCIS) observations on clinical significance, management implications and diagnostic pitfalls of classic, florid and pleomorphic LCIS
Lobular carcinoma in situ (LCIS) is a non-invasive proliferation of atypical dyscohesive epithelial cells characterized by loss or functional...
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Determination of Factors Associated with Upstage in Atypical Ductal Hyperplasia to Identify Low-Risk Patients Where Active Surveillance May be an Alternative
BackgroundExcision is routinely recommended for atypical ductal hyperplasia (ADH) found on core biopsy given cancer upstage rates of near 20%....
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Current Perspectives on Lobular Neoplasia of the Breast
Purpose of ReviewTo present current data on histopathologic types, imaging presentation, and management of lobular neoplasia of the breast.
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Atypical lobular hyperplasia on core needle biopsy: contemporary results from a large community hospital breast program
PurposeThe management of biopsy proven atypical lobular hyperplasia (ALH) is controversial. Although upgrade rates are low, excisional biopsy is...
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Lobular Neoplasia Diagnosed by MRI-Guided Breast Biopsy: Identifying Upgrade Rate to Malignancy and Outcomes of Clinical and Surgical Management
ObjectiveThe aim of this study was to determine surgical and clinical outcomes of lobular neoplasia (LN) diagnosed by magnetic resonance imaging...
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High-risk lesions in the breast diagnosed by MRI-guided core biopsy: upgrade rates and features associated with malignancy
PurposeThis study assessed the upgrade rates of high-risk lesions (HRLs) in the breast diagnosed by MRI-guided core biopsy and evaluated imaging and...
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Immediate and delayed risk of breast cancer associated with classic lobular carcinoma in situ and its variants
ObjectiveTo determine the risk of breast cancer due to lobular carcinoma in situ (LCIS).
MethodsThis retrospective IRB-approved study identified...
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High-Risk Breast Lesions Diagnosed by Ultrasound-Guided Vacuum-Assisted Excision
PurposeThe aim of this study was to analyze the role of ultrasound-guided vacuum-assisted excision (US-guided VAE) in the treatment of high-risk...
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Screening MRI Does Not Increase Cancer Detection or Result in an Earlier Stage at Diagnosis for Patients with High-Risk Breast Lesions: A Propensity Score Analysis
BackgroundGuidelines recommend consideration of screening MRI for patients with high-risk breast lesions (HRLs), acknowledging limited data for this...
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The lobular neoplasia enigma: management and prognosis in a long follow-up case series
BackgroundMany oncologists debate if lobular neoplasia (LN) is a risk factor or an obligatory precursor of more aggressive disease. This study has...
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High-risk and selected benign breast lesions diagnosed on core needle biopsy: Evidence for and against immediate surgical excision
The vast majority of image-detected breast abnormalities are diagnosed by percutaneous core needle biopsy (CNB) in contemporary practice. For frankly...
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Lobular carcinoma in situ: diagnostic criteria and molecular correlates
Lobular neoplasia (LN) is an atypical proliferation of small, dyscohesive epithelial cells within the terminal duct lobular unit (TDLU), with or...
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Upgrade Rates and Breast Cancer Development Among Germline Pathogenic Variant Carriers with High-Risk Breast Lesions
BackgroundHigh-risk lesions (HRL) of the breast are risk factors for future breast cancer development and may be associated with a concurrent...
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Radiologic and Pathologic Correlation of Invasive Lobular Carcinoma of the Breast
Purpose of ReviewThe primary goal of this review is to give an update on the radiologic and pathologic features of invasive lobular carcinoma (ILC),...
