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Atypical chronic myeloid leukemia found in a patient with eosinophilia for six years: a case report
BackgroundAtypical chronic myeloid leukemia (aCML) is a highly aggressive type of blood cancer that falls under the category of...
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Molecular genetics and management of world health organization defined atypical chronic myeloid leukemia
Atypical chronic myeloid leukemia (CML) is a rare BCR::ABL1 -negative hematopoietic stem cell disease characterized by granulocytic proliferation and...
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Transformation of Chronic Lymphocytic Leukemia into Acute Mixed Phenotype Leukemia Myeloid/T Neoplasm: a Case Report
Chronic lymphocytic leukemia (CLL) is defined by the presence of lymphocyte in the blood, bone marrow, lymph nodes, and spleen, with a median...
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European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia
From the laboratory perspective, effective management of patients with chronic myeloid leukemia (CML) requires accurate diagnosis, assessment of...
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An unusual testicular mass: myeloid sarcoma as a rare extramedullary manifestation of acute myeloid leukemia
BackgroundWe report an unusual testicular mass with small bowel and retroperitoneal lymph node deposit proven to be myeloid sarcoma after complete...
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The importance of personalized medicine in chronic myeloid leukemia management: a narrative review
BackgroundTyrosine kinase inhibitors (TKIs) are prescribed as a targeted therapy to treat chronic myeloid leukemia patients. A challenge in clinical...
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Myeloid leukemoid reaction after initial azacitidine therapy for chronic myelomonocytic leukemia
The development of myeloid leukocytosis in leukemia patients during antileukemic treatment requires a differential diagnosis between myeloid...
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Erythroid variant evolving from chronic myeloid leukemia resistant to multiple tyrosine kinase inhibitors: a rare case report
BackgroundChronic myeloid leukemia (CML) is characterized by the presence of BCR::ABL1 fusion gene resulting from a reciprocal translocation,...
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Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era – analysis of the European LeukemiaNet Blast Phase Registry
Blast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the...
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Management of children and adolescents with chronic myeloid leukemia in blast phase: International pediatric CML expert panel recommendations
Treatment of chronic myeloid leukemia has improved significantly with the introduction of tyrosine kinase inhibitors (TKIs), and treatment guidelines...
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Control of Ph+ and additional chromosomal abnormalities in chronic myeloid leukemia by tyrosine kinase inhibitors
Chronic myeloid leukemia (CML) is a type of blood cancer that is known to affect hematopoietic stem cells. The presence of the Philadelphia...
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Asciminib monotherapy in patients with chronic-phase chronic myeloid leukemia with the T315I mutation after ≥1 prior tyrosine kinase inhibitor: 2-year follow-up results
Asciminib targets the BCR::ABL1 myristoyl pocket, maintaining activity against BCR::ABL1 T315I , which is resistant to most approved adenosine...
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Guidelines for the treatment of chronic myeloid leukemia from the NCCN and ELN: differences and similarities
Patients diagnosed with chronic myeloid leukemia (CML) in chronic phase can now have a life expectancy comparable to that of the general population...
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Late relapse of chronic myeloid leukemia after allogeneic bone marrow transplantation points to KANSARL (KANSL1::ARL17A) alteration: a case report with insights on the molecular landscape
Chronic myeloid leukemia is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome and the consequent BCR::ABL1...
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A clinician perspective on the treatment of chronic myeloid leukemia in the chronic phase
Tyrosine kinase inhibitors (TKIs) have vastly improved long-term outcomes for patients with chronic myeloid leukemia (CML). After imatinib (a...
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Isolated bone marrow sarcoidosis presenting as fever of unknown origin in a case of chronic myeloid leukemia
BackgroundIsolated involvement of bone marrow in sarcoidosis has not been reported commonly. Sarcoidosis is a systemic granulomatous disease of...
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Unusual Presentation of Concurrent Cutaneous Plasmablastic Lymphoma and Acute Myeloid Leukemia: a Case Report and a Comprehensive Review
Plasmablastic lymphoma (PBL) is a rare type of non-Hodgkin’s lymphoma, primarily seen in patients with immunosuppression, particularly HIV. It...
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Three atypical BCR/ABL transcripts detected simultaneously in a Philadelphia-positive acute lymphoblastic leukemia patient showing resistance to tyrosine kinase inhibitors
The Philadelphia (Ph) chromosome with a BCR/ABL fusion gene is a characteristic feature of chronic myeloid leukemia (CML) and partial acute...
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Estimating prognostic relevant cutoff values for a multiplex PCR detecting BCR::ABL1 in chronic myeloid leukemia patients on tyrosine kinase inhibitor therapy in resource-limited settings
The prognosis of chronic myeloid leukemia (CML) on tyrosine kinase inhibitor (TKI) treatment is based on the quantification of BCR::ABL1 fusion gene...
