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Drastic Loss of Antral Follicles Due to Gene Expression Dysregulation Occurs on the First Day After Subcutaneous Ovarian Transplantation
Ovarian cryopreservation is an alternative for the preservation of fertility, and the subcutaneous transplantation site is considered one of the most...
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The Dominant Mechanism of Cyclophosphamide-Induced Damage to Ovarian Reserve: Premature Activation or Apoptosis of Primordial Follicles?
Cyclophosphamide (CPM), a part of most cancer treatment regimens, has demonstrated high gonadal toxicity in females. Initially, CPM is believed to...
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Tamoxifen Activates Dormant Primordial Follicles in Mouse Ovaries
Our previous study found that 17β-estradiol (E 2 ) suppresses primordial follicle activation and growth in cultured mouse ovaries. In this study, we...
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The effect of large follicle puncture and aspiration on the outcomes of IVF-ET in patients with asynchronized follicles under the long GnRH-a protocol: a retrospective cohort study
ObjectiveThis retrospective study aimed to explore whether puncturing and aspirating asynchronized large follicles during long GnRH-a protocol COH...
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MicroRNA-144-3p protects against chemotherapy-induced apoptosis of ovarian granulosa cells and activation of primordial follicles by targeting MAP3K9
Premature ovarian failure (POF) is defined by amenorrhea, ovarian atrophy, hypoestrogenism, elevated gonadotropin level, and infertility under the...
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Hormone concentrations of dominant follicles in the TALES randomized controlled trial comparing letrozole with tamoxifen
BackgroundIn this secondary analysis of the TAmoxifen or Letrozole in Estrogen Sensitive tumors (TALES) trial, we aimed to investigate if concurrent...
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In vitro growth (IVG) of human ovarian follicles in frozen thawed ovarian cortex tissue culture supplemented with follicular fluid under hypoxic conditions
BackgroundDespite its clinical success rates, transplantation after ovarian tissue cryopreservation (OTC) remains a matter of concern. Certain cancer...
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Folliculogenesis and steroidogenesis alterations after chronic exposure to a human-relevant mixture of environmental toxicants spare the ovarian reserve in the rabbit model
BackgroundIndustrial progress has led to the omnipresence of chemicals in the environment of the general population, including reproductive-aged and...
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Protective effect of Luffa cylindrica fermentation liquid on cyclophosphamide-induced premature ovarian failure in female mice by attenuating oxidative stress, inflammation and apoptosis
Premature ovarian failure (POF) is a leading cause of women’s infertility without effective treatment. The purpose of this study was to investigate...
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Amniotic fluid-derived exosomes attenuated fibrotic changes in POI rats through modulation of the TGF-β/Smads signaling pathway
In the current study, we investigated the regenerative effects of amniotic fluid exosomes (AF-Exos) in a rat model for premature ovarian...
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The effect of human menstrual blood-derived stem cells on ovarian folliculogenesis, angiogenesis and collagen volume in female rats affected by the polycystic ovary syndrome
BackgroundInfertility is one of the common problems among couples, affecting millions of people worldwide. Polycystic ovary syndrome (PCOS) is one of...
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Ultrasonographic and histopathological investigation of the effect of N-acetylcysteine on doxorubicin-induced ovarian and uterine toxicity in rats
BackgroundThis study aimed to investigate the mitigating effect of N-acetylcysteine (NAC) on doxorubicin (DOX)-induced ovarian and uterine toxicity...
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Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies
ObjectiveThis study aims to investigate the effects of natural products on animal models of premature ovarian failure (POF).
MethodsWe conducted...
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Loss of p16 does not protect against premature ovarian insufficiency caused by alkylating agents
BackgroundChemical agents such as alkylating agents (AAs) that are commonly used for the treatment of cancer cause great damage to the ovaries,...
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A prospective, observational study of chemotherapy-induced ovarian damage on follicular reserve and maturation
BackgroundChemotherapy negatively affects gonadal function, often resulting in premature ovarian failure (POF) due to ovarian reserve depletion....
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Investigating the impact of vitrification on bovine ovarian tissue morphology, follicle survival, and transcriptomic signature
PurposeOvarian tissue cryopreservation is vital for fertility preservation, yet its effect on ovarian tissue follicle survival and transcriptomic...
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Loss of Calponin 2 causes premature ovarian insufficiency in mice
BackgroundPremature ovarian insufficiency (POI) is a condition defined as women develo** menopause before 40 years old. These patients display low...
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Histological, immunohistochemical and serological investigations of the ovary during follicular phase of estrous cycle in Saidi sheep
BackgroundSaidi sheep are the most abundant ruminant livestock species in Upper Egypt, especially in the Assiut governorate. Sheep are one of the...
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5-Fluorouracil disrupts ovarian preantral follicles in young C57BL6J mice
Purpose5-Fluorouracil (5-FU), an anti-cancer drug, has been used for hepatoblastoma (HB) chemotherapy in children, who may have impaired ovarian...
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The Differential Metabolomes in Cumulus and Mural Granulosa Cells from Human Preovulatory Follicles
This studyevaluated the differences in metabolites between cumulus cells (CCs) and mural granulosa cells (MGCs) from human preovulatory follicles to...
