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Assessing asthma symptoms in children: qualitative research supporting the development of the Pediatric Asthma Diary—Child (PAD-C) and Pediatric Asthma Diary—Observer (PAD-O)
BackgroundPediatric asthma has been identified by regulators, clinicians, clinical trial sponsors, and caregivers as an area in need of novel...
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Benchmarking omics-based prediction of asthma development in children
BackgroundAsthma is a heterogeneous disease with high morbidity. Advancement in high-throughput multi-omics approaches has enabled the collection of...
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Development of a risk prediction model to predict the risk of hospitalization due to exacerbated asthma among adult asthma patients in a lower middle-income country
BackgroundAsthma patients experience higher rates of hospitalizations due to exacerbations leaving a considerable clinical and economic burden on the...
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Early prediction of pediatric asthma in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort using machine learning
BackgroundEarly identification of children at risk of asthma can have significant clinical implications for effective intervention and treatment....
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Risk factors of sleep-disordered breathing and poor asthma control in children with asthma
BackgroundSleep-disordered breathing (SDB) may lead to poor asthma control in children.
ObjectiveTo identify risk factors of SDB in children with...
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Development of a real-world database for asthma and COPD: The SingHealth-Duke-NUS-GSK COPD and Asthma Real-World Evidence (SDG-CARE) collaboration
PurposeThe SingHealth-Duke-GlaxoSmithKline COPD and Asthma Real-world Evidence (SDG-CARE) collaboration was formed to accelerate the use of...
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Association between constipation and the development of asthma: a meta-analysis
BackgroundConstipation has been hypothesized to be associated with the increased risk of wheezing or asthma. However, the relation remains a subject...
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Development and Utilization of a Diagnostic Support Tool for Asthma within the Electronic Medical Record
Asthma in childhood is a common and costly chronic disease. Quality asthma care can lead to better control of asthma thus decreasing use of health...
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Clinical inertia in asthma
Despite advances in pharmaceutical treatment in recent years, a relatively high proportion of patients with asthma do not have adequate asthma...
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Prevalence of bronchial asthma and correlation between the chemokine receptor 3 gene polymorphism and clinical asthma phenotypes among Egyptian asthmatic children
BackgroundAsthma is a chronic inflammatory airway disease characterized by episodic reversible airway obstruction that variably presents with cough,...
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Maternal asthma and asthma exacerbation during pregnancy and attention-deficit/hyperactivity disorder in offspring: a population-based cohort study
The link between inflammatory disorders, such as asthma, and attention deficit hyperactivity disorder (ADHD) is attracting increasing attention but...
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Recent Insights into the Environmental Determinants of Childhood Asthma
Purpose of ReviewUbiquitous environmental exposures, including ambient air pollutants, are linked to the development and severity of childhood...
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IMP2ART: development of a multi-level programme theory integrating the COM-B model and the iPARIHS framework, to enhance implementation of supported self-management of asthma in primary care
BackgroundSupported asthma self-management, incorporating an asthma action plan and annual clinical review, has been recommended by UK/global...
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CC16 polymorphisms in asthma, asthma subtypes, and asthma control in adults from the Agricultural Lung Health Study
BackgroundThe club cell secretory protein (CC16) has anti-inflammatory and antioxidant effects and is a potential early biomarker of lung damage. The
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Childhood asthma and mould in homes—A meta-analysis
Asthma is a multifaceted and multicausal disease. Childhood asthma is strongly influenced by genetic traits and is characterized by hyperreactivity...
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Effect of fractional exhaled nitric oxide (FENO)-based asthma management during pregnancy versus usual care on infant development, temperament, sensory function and autism signs
Asthma during pregnancy is associated with a range of adverse perinatal outcomes. It is also linked to increased rates of neurodevelopmental...
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Barriers to clinical remission in severe asthma
Severe asthma is associated with an increased risk for exacerbations, reduced lung function, fixed airflow obstruction, and substantial morbidity and...
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Optimizing care for children with difficult-to-treat and severe asthma through specialist paediatric asthma centres: expert practical experience and advice
Severe asthma in children carries an unacceptable treatment burden, yet its rarity means clinical experience in treating it is limited, even among...
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Increasing the accuracy of the asthma diagnosis using an operational definition for asthma and a machine learning method
IntroductionAnalysis of the National Health Insurance data has been actively carried out for the purpose of academic research and establishing...
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Patient education needs in severe asthma, a pilot study
BackgroundSevere asthma is characterized by frequent exacerbations, altered lung function, and impaired quality of life. Tailored patient education...
