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Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP, TGFβ, and Wnt signaling in articular cartilage formation and osteoarthritis
Runt-related transcription factor 1 (Runx1) plays a key role in cartilage formation, but its function in articular cartilage formation is unclear. We...
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Low-intensity pulsed ultrasound irradiation attenuates collagen degradation of articular cartilage in early osteoarthritis-like model mice
PurposeOsteoarthritis (OA) is a combination of degeneration and destruction of articular cartilage due to mechanical stress, secondary synovitis, and...
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Application of diffuse optical back reflection spectroscopy for determining articular cartilage thickness in a clinical setting
PurposeDevelop a spectroscopic method to assess cartilage thickness during the arthroscopic examination.
MethodsCurrently, arthroscopy assesses...
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Chondrotoxic effects of tranexamic acid and povidone-iodine on the articular cartilage of rabbits
PurposeTo evaluate the chondrotoxic effects of intra-articular use of TXA 20 mg/kg and/or 0.35% PVPI on knee joint cartilage in an experimental model...
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Return to Play After Knee Articular Cartilage Restoration: Surgical Options, Rehabilitation Protocols, and Performance Outcomes
Purpose of ReviewNumerous cartilage restoration techniques have proven to be effective in the treatment of articular cartilage defects. The ultimate...
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Bevacizumab suppressed degenerative changes in articular cartilage explants from patients with osteoarthritis of the knee
BackgroundThis study was designed to test the hypothesis that blockade of vascular endothelial growth factor (VEGF) suppresses degenerative changes...
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Specific lipid magnetic sphere sorted CD146-positive bone marrow mesenchymal stem cells can better promote articular cartilage damage repair
BackgroundThe characteristics and therapeutic potential of subtypes of bone marrow mesenchymal stem cells (BMSCs) are largely unknown. Also, the...
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Mincing bovine articular cartilage with commercially available shavers reduces the viability of chondrocytes compared to scalpel mincing
PurposeThe study aimed to compare the effect of mincing bovine articular cartilage with different shaver blades on chondrocyte viability.
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Tendon stem/progenitor cells are promising reparative cell sources for multiple musculoskeletal injuries of concomitant articular cartilage lesions associated with ligament injuries
BackgroundTrauma-related articular cartilage lesions usually occur in conjunction with ligament injuries. Torn ligaments are frequently reconstructed...
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Intra-articular injections in sport-active patients with degenerative cartilage lesions or osteoarthritis of the knee: a systematic review
PurposeThe aim of this systematic review was to analyse the available clinical evidence on intra-articular knee injections for the treatment of...
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MRI-based cartilage changes and clinical effectiveness of autologous intra-articular platelet-rich plasma injections in symptomatic patients with moderate osteoarthritis of the knee
BackgroundAn autologous blood product containing a high percentage of various growth factors, cytokines, and modulating factors such as platelet-rich...
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Current concepts and perspectives for articular cartilage regeneration
Articular cartilage injuries are common in the population. The increment in the elderly people and active life results in an increasing demand for...
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Osseous variations associated with physiological thinning of the glenoid articular cartilage: an osteological study with CT, MRI and arthroscopic correlations
ObjectiveTo investigate the relationship between osseous variations of the glenoid fossa and thinning of the overlaying articular cartilage.
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Patellofemoral articular cartilage damage is associated with poorer patient-reported outcomes following isolated medial patellofemoral ligament reconstruction
PurposeThe purpose of this study was to investigate the impact of articular cartilage damage on outcomes following medial patellofemoral ligament...
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The presence and degradation of nerve fibers in articular cartilage of neonatal rats
PurposeTo investigate the presence and change of nerve fibers and neuropeptide during early development of articular cartilage in neonatal rats.
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Impaired autophagy contributes to the aggravated deterioration of osteoarthritis articular cartilage by peroxisome proliferator-activated receptor α deficiency, associated with decreased ERK and Akt activation
BackgroundAlthough the chondroprotection of peroxisome proliferator-activated receptor α (PPARα) activation against osteoarthritis (OA) has been...
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Rheumatoid arthritis increases the risk of malignant neoplasm of bone and articular cartilage: a two-sample bidirectional mendelian randomization study
ObjectivePrior research has revealed a heightened prevalence of neoplasms in individuals diagnosed with rheumatoid arthritis (RA). The primary...
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Effects of intra-articular injection of platelet-rich plasma on the inflammatory process and histopathological characteristics of cartilage and synovium in animals with osteoarthritis: a systematic review with meta-analysis
BackgroundOsteoarthritis (OA) affects the entire joint, causing structural changes in articular cartilage, subchondral bone, ligaments, capsule,...
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Postoperative quadriceps weakness and male sex are risk factors for patellofemoral articular cartilage lesions after anatomical anterior cruciate ligament reconstruction
PurposePatellofemoral (PF) compartment cartilage lesions are a frequent problem after anterior cruciate ligament (ACL) reconstruction. This study...
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Role of percutaneous CT–guided radiofrequency ablation in treatment of intra-articular, in close contact with cartilage and extra-articular osteoid osteomas: comparative analysis and new classification system
PurposeWe investigated procedural safety, technical and clinical outcomes of the percutaneous image-guided radiofrequency ablation (PRFA) of...
