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Safety and efficacy of artesunate treatment in severely injured patients with traumatic hemorrhage. The TOP-ART randomized clinical trial
PurposeThis study aimed at determining whether intravenous artesunate is safe and effective in reducing multiple organ dysfunction syndrome in trauma...
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Antitumour effects of artesunate via cell cycle checkpoint controls in human oesophageal squamous carcinoma cells
Artesunate (ART), an effective antimalarial semisynthetic derivative of artemisinin, exhibits antitumour properties, but the mechanism(s) involved...
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Effect of artesunate on cardiovascular complications in periodontitis in a type I diabetes rat model and related mechanisms
PurposeBoth cardiovascular disease and periodontitis are complications of diabetes that have a great impact on human life and health. Our previous...
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Efficacy of artesunate combined with Atractylodes lancea or Prabchompoothaweep remedy extracts as adjunctive therapy for the treatment of cerebral malaria
BackgroundCerebral malaria is one of the most serious complications of Plasmodium infection and causes behavioral changes. However, current...
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Artesunate attenuates the tumorigenesis of choroidal melanoma via inhibiting EFNA3 through Stat3/Akt signaling pathway
PurposeChoroidal melanoma (CM), a kind of malignant tumor, is the main type of Uveal melanoma and one half of CM patients develop metastases. As a...
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Effectiveness of rectal artesunate as pre-referral treatment for severe malaria in children under 5 years of age: a multi-country observational study
BackgroundTo prevent child deaths from severe malaria, early parenteral treatment is essential. Yet, in remote rural areas, accessing facilities...
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Efficacy and safety of artesunate for patients with IgA nephropathy: a study protocol for a multicenter, double-blind, randomized, placebo-controlled trial
BackgroundIgA nephropathy is the most common glomerular disease and is a common cause of progression to end-stage renal disease in patients with...
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Role of Artesunate on cardiovascular complications in rats with type 1 diabetes mellitus
BackgroundThe present study aimed to evaluate the effect of artesunate (ART) on the reduction of cardiovascular complications in a type 1 diabetes...
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Effect of artesunate and relation with TGF-β1 and SMAD3 signaling on experimental hypertrophic scar model in rabbit ear
Artesunate (ART) is the derivative of artemisinin isolated from the traditional Chinese medicine qinghao . Although several studies reported the...
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Artesunate prevents knee intraarticular adhesion via PRKR-like ER kinase (PERK) signal pathway
BackgroundIntraarticular scar adhesion refers to a serious complication caused by knee surgery or trauma, leading to various sequelae (e.g.,...
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Assessment of availability and challenges of WHO recommended priority life-saving medicines for under five-year children in primary public health facilities of Amhara region
BackgroundThe world health organization (WHO) priority lifesaving medicines are medicines recommended for the prevention and treatment of leading...
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An analysis of Plasmodium falciparum-K13 mutations in India
Malaria is one of the deadliest parasitic diseases in human. Currently, Artemisinin-based combination therapy is considered as the gold standard and...
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Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs
BackgroundDihydroartemisinin-piperaquine (DHA-PPQ) is an alternative first-line antimalarial to artemether-lumefantrine in Kenya. However, recent...
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New clinical application prospects of artemisinin and its derivatives: a sco** review
BackgroundRecent research has suggested that artemisinin and its derivatives may have therapeutic effects on parasites, viruses, tumors, inflammation...
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Natural products as potential drug treatments for acute promyelocytic leukemia
Acute promyelocytic leukemia (APL), which was once considered one of the deadliest types of leukemia, has become a curable malignancy since the...
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The landscape of drug resistance in Plasmodium falciparum malaria in the Democratic Republic of Congo: a map** systematic review
ContextThe Democratic Republic of Congo (DRC), one of the most malaria-affected countries worldwide, is a potential hub for global drug-resistant...
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Managing Lupus Nephritis in Children and Adolescents
Lupus nephritis is an important manifestation of systemic lupus erythematosus, which leads to chronic kidney disease, kidney failure, and can result...
