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No Incidence of Liver Cancer Was Observed in A Retrospective Study of Patients with Aristolochic Acid Nephropathy
ObjectiveTo assess the risk of aristolochic acid (AA)-associated cancer in patients with AA nephropathy (AAN).
MethodsA retrospective study was...
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Stir-fried Semen Armeniacae Amarum Suppresses Aristolochic Acid I-Induced Nephrotoxicity and DNA Adducts
ObjectiveTo investigate the protective effects of stir-fried Semen Armeniacae Amarum (SAA) against aristolochic acid I (AAI)-induced nephrotoxicity...
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Aristolochic acid-containing Chinese herbal medicine and upper urinary tract urothelial carcinoma in Taiwan: a narrative review
PurposeThe high incidence of upper urinary tract urothelial carcinoma (UTUC) in Taiwan is largely due to exposure to aristolochic acid (AA), a...
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Schisandra chinensis Oil Attenuates Aristolochic Acid I-Induced Nephrotoxicity in vivo and in vitro
ObjectiveTo investigate the protective effects of Schisandra chinensis oil (SCEO) against aristolochic acid I (AA I)-induced nephrotoxicity in vivo ...
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Trends in the incidence of urothelial carcinoma in Taiwan after the ban on aristolochic acid-containing Chinese herbal preparations, 2001–2018: a national population-based cohort study
PurposeUrothelial carcinoma (UC) of the bladder (BUC) and the upper urinary tract (UTUC) are the two most common UCs. The incidence of UTUC in Taiwan...
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De novo upper tract urothelial carcinoma after renal transplantation: a single-center experience in China
BackgroundLong-term prognosis and risk factors of de novo upper tract urothelial carcinoma after renal transplantation were rarely studied. Thus, the...
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Clinicopathologic characteristics and prognosis of upper tract urothelial carcinoma complicated with aristolochic acid nephropathy after radical nephroureterectomy
BackgroundThe purpose of this study was to identify the clinicopathologic characteristics and prognosis of upper tract urothelial carcinoma (UTUC)...
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Oleanolic acid and its analogues: promising therapeutics for kidney disease
Kidney diseases pose a significant threat to human health due to their high prevalence and mortality rates. Worryingly, the clinical use of drugs for...
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Integrated genomic analyses of hepatocellular carcinoma
BackgroundGenomic alterations play important roles in the development of cancer. We explored the impact of protein-coding genes and transcriptomic...
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Tanshinone I attenuates fibrosis in fibrotic kidneys through down-regulation of inhibin beta-A
BackgroundTanshinone I (Tan-I), an ingredient of Salvia miltiorrhiza, displays protective effects in several disease models. We aim to study the...
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Exploring the antimicrobial activity of Origanum majorana L. against the highly virulent multidrug-resistant Acinetobacter baumannii AB5075: UPLC-HRMS profiling with in vitro and in silico studies
BackgroundThe infamous multidrug-resistant (MDR) bacterium Acinetobacter baumannii is becoming a nightmare in intensive care units across the globe....
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Global burden, risk factors, and temporal trends of ureteral cancer: a comprehensive analysis of cancer registries
BackgroundUreteral cancer is a rare cancer. This study aimed to provide an up-to-date and comprehensive analysis on the global trends of ureteral...
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Molecular evolution in different subtypes of multifocal hepatocellular carcinoma
BackgroundMultifocal hepatocellular carcinoma (MF-HCC) accounts for > 40% of HCCs, exhibiting a poor prognosis than single primary HCCs....
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A case of Fanconi syndrome that developed following a year of consumption of a red yeast rice supplement
Although some dietary supplements have been reported to cause renal dysfunction, there have been few reports of supplement-induced Fanconi syndrome....
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Acute kidney injury decreases pulmonary vascular growth and alveolarization in neonatal rat pups
BackgroundAcute kidney injury (AKI) is common in sick neonates and associated with poor pulmonary outcomes, however, the mechanisms responsible...
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Patients undergoing liver resection for non-alcoholic fatty liver disease-related hepatocellular carcinoma and those for viral hepatitis-related hepatocellular carcinoma have similar survival outcomes
Numerous studies have compared outcomes of liver resection (LR) of patients with non-alcoholic fatty liver disease (NAFLD)-related hepatocellular...
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Pathological consequences of DNA damage in the kidney
DNA lesions that evade repair can lead to mutations that drive the development of cancer, and cellular responses to DNA damage can trigger senescence...
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Randomized control trial of prednisolone and doxycycline in patients with acute interstitial nephritis of unknown aetiology
BackgroundPatients presenting with acute interstitial nephritis (AIN) of unknown aetiology, probably the earliest presentation of chronic kidney...
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Transcriptional regulation of proximal tubular metabolism in acute kidney injury
The kidney, and in particular the proximal tubule (PT), has a high demand for ATP, due to its function in bulk reabsorption of solutes. In normal PT,...
