Search
Search Results
-
Apigenin inhibits angiogenesis in retinal microvascular endothelial cells through regulating of the miR-140-5p/HDAC3-mediated PTEN/PI3K/AKT pathway
BackgroundDiabetic retinopathy (DR) is a common cause of visual impairment. Apigenin has been shown to have antiangiogenic effects in various...
-
Protective and therapeutic effects of apigenin on thioacetamide-induced hepatotoxicity in male rats: physiological and morphological study
BackgroundLiver fibrosis is an irreversible liver destruction. Apigenin (API) has different pharmacological properties as anticancer,...
-
Apigenin impedes cell cycle progression at G2 phase in prostate cancer cells
As a natural flavone, apigenin is abundantly present in vegetables, fruits, oregano, tea, chamomile, wheat sprout and is regarded as a major...
-
Apigenin reduces the suppressive effect of exosomes derived from irritable bowel syndrome patients on the autophagy of human colon epithelial cells by promoting ATG14
BackgroundInflammatory bowel disease (IBS) is a chronic disorder of the gastrointestinal tract. Exosomes have been involved in various pathological...
-
Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair cells
Oxidative stress plays an important role in the pathogenesis of aminoglycoside-induced hearing loss and represents a promising target for treatment....
-
Apigenin increases radiosensitivity of glioma stem cells by attenuating HIF-1α-mediated glycolysis
Apigenin, a natural flavonoid compound present in a variety of edible plants and health foods, has an anti-tumor effect and inhibits hypoxia...
-
Network pharmacology-based study on apigenin present in the methanolic fraction of leaves extract of Cestrum nocturnum L. to uncover mechanism of action on hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the sixth most common type of cancer in the world. It is the third leading cause of cancer-related mortality. In...
-
A single robust stability-indicating RP-HPLC analytical tool for apigenin quantification in bulk powder and in nanoliposomes: a novel approach
BackgroundApigenin (4′, 5, 7-trihydroxyflavone), a flavonoid, is present usually in fruits and vegetables possessing numerous biological properties...
-
Apigenin effect against Leishmania tropica amastigotes in vitro
Cutaneous Leishmaniasis is a current public health problem in Syria. It causes different skin lesions that vary in their severity from spontaneously...
-
Evaluation of cholinesterase inhibitory and antioxidant activity of Wedelia chinensis and isolation of apigenin as an active compound
BackgroundWedelia chinensis has been reported as a folk medicine for the treatment of different diseases including neurodegenerative disease....
-
Identification of 3,3′-O-dimethylellagic acid and apigenin as the main antiplasmodial constituents of Endodesmia calophylloides Benth and Hymenostegia afzelii (Oliver.) Harms
BackgroundEndodesmia calophylloides and Hymenostegia afzelii belong to the Guttiferae and Caesalpiniaceae plant families with known uses in African...
-
Protective effects of apigenin against Bisphenol A-induced testis toxicity in Wistar rats through modulating hepatic biochemical biomarkers and histological changes
Apigenin (APG) is a phytopolyphenol widely distributed in the human diet and has been reported to exert antioxidant effects, such as lowering...
-
A natural flavonoid, apigenin isolated from Clerodendrum viscosum leaves, induces G2/M phase cell cycle arrest and apoptosis in MCF-7 cells through the regulation of p53 and caspase-cascade pathway
BackgroundWith 9.6 million deaths in 2018, cancer remains the second leading cause of death worldwide. Breast cancer is the most deadly type of...
-
Integrated network pharmacology and cellular assay reveal the biological mechanisms of Limonium sinense (Girard) Kuntze against Breast cancer
BackgroundLimonium Sinense (Girard) Kuntze ( L. sinense ) has been widely used for the treatment of anaemia, bleeding, cancer, and other disorders in...
-
Analyzing the molecular mechanism of Scutellaria Radix in the treatment of sepsis using RNA sequencing
BackgroundSepsis is a life-threatening organ dysfunction, which seriously threatens human health. The clinical and experimental results have...
-
Phytoconstituents of Artemisia annua as potential inhibitors of SARS CoV2 main protease: an in silico study
BackgroundIn November 2019, the world faced a pandemic called SARS-CoV-2, which became a major threat to humans and continues to be. To overcome...
-
Interaction of apigenin-7-O-glucoside with pyrimethamine against Toxoplasma gondii growth
Apigenin-7-O-glucoside, a flavonoid glucoside known to inhibit cancer cell growth, fungi growth, both intra and extracellular reactive oxygen species...
-
Ameliorative effects of Scutellaria Pinnatifida subsp. pichleri (Stapf) Rech.f. Extract in streptozotocin-induced diabetic rats: chemical composition, biochemical and histopathological evaluation
BackgroundsScutellaria Pinnatifida subsp. pichleri (Stapf) Rech.f. (SP) is used in folk medicine for the treatment of diabetes. The aim of the study...
-
Integrating network pharmacology and experimental models to investigate the efficacy and mechanism of Tiansha mixture on xerosis
Epidermal Growth Factor Receptor Inhibitors (EGFRIs) is a common cancer therapy, but they occasionally cause severe side effects such as xerosis. Tiansha...
-
Comparison of inhibitory activities of 50 Salvia species against α-Glucosidase
ObjectivesType 2 diabetes is a common metabolic disease affecting millions of people worldwide. α-Glucosidase inhibitors can be used as one of the...
