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Design, synthesis, and evaluation of anxiolytic activity of 2-(4-phenylpiperazin-1-yl)-1H-benz[d]imidazole and 2-(4-phenylpiperazin-1-methyl)-1H-benz[d]imidazole derivatives
BackgroundIn contemporary society, anxiety has become a widespread disorder leading to compromised well-being and heightened depressive states....
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µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice
Mood and anxiety disorders are leading causes of disability worldwide and are major contributors to the global burden of diseases. Neuropeptides,...
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Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons
Diabetic patients receiving the antidiabetic drug metformin have been observed to exhibit a lower prevalence of anxiety disorders, yet the precise...
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High-resolution tracking of unconfined zebrafish behavior reveals stimulatory and anxiolytic effects of psilocybin
Serotonergic psychedelics are emerging therapeutics for psychiatric disorders, yet their underlying mechanisms of action in the brain remain largely...
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Anxiolytic and antidepressants’ effect of Crataegus pinnatifida (Shan Zha): biochemical mechanisms
Depression and anxiety disorders are highly prevalent. Selective serotonin reuptake inhibitors (SSRIs) are the current first-line treatment for...
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Anxiolytic, analgesic and anti-inflammatory effects of Citrus maxima (Burm.) Merr. Seed extract in Swiss albino mice model
BackgroundCitrus maxima (Burm.) Merr. is traditionally used for its diverse pharmacological properties. Therefore, there remains a possibility that...
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Anxiolytic-like effect of Suanzaoren–Wuweizi herb-pair and evidence for the involvement of the monoaminergic system in mice based on network pharmacology
BackgroundSuanzaoren-Wuweizi herb-pair (SWHP), composed of Zizyphi Spinosi Semen (Suanzaoren in Chinese) and Schisandrae Chinensis Fructus (Wuweizi...
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Satisfaction with Anxiolytic and Hypnotic Drug Treatment: Validation of the TSAN Questionnaire
The aim is to develop and validate a specific instrument for measuring satisfaction with anxiolytic and hypnotic drug treatment. We determined the...
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Antagonization of monoamine reuptake transporters by agmatine improves anxiolytic and locomotive behaviors commensurate with fluoxetine and methylphenidate
BackgroundAgmatine (AGM) is known for its protective effects including neuroprotection, nephroprotection, gastroprotection, cardioprotection, and...
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Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation
Sleep deprivation is a form of stress that provokes both inflammatory responses and neuropsychiatric disorders. Because persistent inflammation is...
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Exploration of in vitro thrombolytic, anthelminthic, cytotoxic and in vivo anxiolytic potentials with phytochemical screening of flowers of Brassica nigra
BackgroundBrassica nigra is a plant of Brassicaceae family, which possesses numerous medicinal values. Our present study is intended to assess the...
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Comparison of S-ketamine and midazolam for intravenous preoperative sedative and anxiolytic effects in preschool children: study protocol for a randomized controlled clinical trial
BackgroundPreoperative anxiety management is gaining particular attention in paediatric anaesthesia. Pharmacological and non-pharmacological resorts...
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Association Between Physical Activity, Sedentary Behaviors, and Sleep-Related Outcomes Among Cancer Survivors: a Cross-Sectional Study
BackgroundLimited research has examined the association between moderate to vigorous physical activity (MVPA), sedentary behavior (SB), and...
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The antidepressant and anxiolytic effects of cannabinoids in chronic unpredictable stress: a preclinical systematic review and meta-analysis
Neuroscience research presents contradictory evidence in support of both the protective and destructive effects of cannabinoids in depression....
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Anxiolytic-like effect of Urena lobata (L.) in swiss albino mice
Anxiety disorders are general and psychological problems that are also linked to symptoms of depression. This study aimed to investigate the...
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Recommendations of the Schizophrenia Expert Center network for adequate physical activity in real-world schizophrenia (FACE-SZ)
The World Health Organization (WHO) recommends adults complete 150–300 min per week of moderate physical activity or 75–150 min of vigorous physical...
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Methanol extract of Spathodea campanulata P. (Beauv.) leaves demonstrate sedative and anxiolytic like actions on swiss albino mice
BackgroundSpathodea campanulata P. Beauv. (Bignoniaceae) is a very common plant in Bangladesh which is locally called “Rudrapalash”. In Nigeria...
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Lysergic Acid Diethylamide (LSD) for the Treatment of Anxiety Disorders: Preclinical and Clinical Evidence
Anxiety disorders (ADs) represent the sixth leading cause of disability worldwide, resulting in a significant global economic burden. Over 50% of...
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Interactions between neurotrophins, mood, and physical activity under the conditions of sleep deprivation
Sleep deprivation (DS) is the forced elimination of sleep. While brain-derived neurotrophic factor (BDNF) has been extensively studied in the context...
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Age-associated changes in electroretinography measures in companion dogs
PurposeTo determine the association between age and retinal full-field electroretinographic (ERG) measures in companion (pet) dogs, an important...
