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Treatment Patterns with Mirabegron and Antimuscarinics for Overactive Bladder: A Prospective, Registry Study in Taiwan and South Korea (FAITH)
IntroductionThis study aimed to assess overactive bladder (OAB) treatment patterns and factors associated with effectiveness and persistence.
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Management of use of urinary antimuscarinics and alpha blockers for benign prostatic hyperplasia in older adults at risk of falls: a clinical review
PurposeWe aimed to outline the existing information and the underlying mechanisms of risk of falls associated with the use of urinary antimuscarinics...
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The efficacy and safety of antimuscarinics for the prevention or treatment of catheter-related bladder discomfort: a systematic review and meta-analysis of randomized controlled trials
ObjectivesThis meta-analysis aimed to evaluate the efficacy and safety of antimuscarinics for the prevention or treatment of catheter related bladder...
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On-demand use of fesoterodine: a new paradigm for extended release antimuscarinics
Introduction and hypothesisWe aimed to compare on-demand and continuous use of fesoterodine 4 mg concerning efficacy and adverse effects.
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Comparison of add-on medications for persistent storage symptoms after α-blocker treatment in BPH patients – a network meta-analysis
BackgroundPatients with benign prostatic hyperplasia (BPH) receive α-blockers as first-line therapy to treat lower urinary tract symptoms; however,...
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Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options
This article provides an overview of the diagnosis and the treatment of lower urinary tract symptoms in older adults complicated by the...
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Treatment outcome of women with urodynamic mixed urinary incontinence: an observational study
Introduction and hypothesisMixed urinary incontinence (MUI) is a common yet understudied condition. It remains a therapeutic challenge, with the...
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Cardiovascular Risk in Users of Mirabegron Compared with Users of Antimuscarinic Treatments for Overactive Bladder: Findings from a Non-Interventional, Multinational, Cohort Study
IntroductionDuring clinical trials, mirabegron, a β3-adrenoreceptor agonist, was associated with increased vital signs vs placebo in patients with...
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Pharmacological interventions for antipsychotic-related sialorrhea: a systematic review and network meta-analysis of randomized trials
Antipsychotic-induced sialorrhea carries a significant burden, but evidence-based treatment guidance is incomplete, warranting network meta-analysis...
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Antimuscarinic Cascade Across Individual Cholinesterase Inhibitors in Older Adults with Dementia
BackgroundAcetylcholinesterase inhibitors (AChEIs) have been associated with an increased risk of starting antimuscarinic treatment to treat...
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Skin sympathetic nerve activity as a potential biomarker for overactive bladder
PurposeAbnormalities in autonomic function are associated with an overactive bladder (OAB). Heart rate variability is generally used as the sole...
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Comparative Safety and Efficacy of Treatments for Overactive Bladder Among Older Adults: A Network Meta-analysis
BackgroundCumulative exposure to one or more anticholinergic medications (“anticholinergic burden”) is associated with an increased risk of adverse...
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Are Beta 3 Adrenergic Agonists Now the Preferred Pharmacologic Management of Overactive Bladder?
Purpose of the ReviewThis paper discusses the recent evidence supporting beta 3 adrenergic agonists as the preferred pharmacological management of...
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Relative Risk of Adverse Events and Treatment Discontinuations Between Older and Non-Older Adults Treated with Antimuscarinics for Overactive Bladder: A Systematic Review and Meta-Analysis
IntroductionOveractive bladder (OAB) affects adults of all ages. The risk for medication-related adverse events (AEs) may differ between age groups,...
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Vibegron 50 mg is the optimal algorithm in the pharmacologic management of overactive bladder: outcomes from a systematic review and meta-analysis
PurposeThe efficacy and safety of vibegron, which is a novel β3-adrenoceptor agonist, need to be systematically evaluated in the treatment of...
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A retrospective study of treatment persistence and adherence to mirabegron versus antimuscarinics, for the treatment of overactive bladder in Spain
BackgroundPersistence on-treatment with antimuscarinics in patients with overactive bladder (OAB) is reported to be sub-optimal. This retrospective,...
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Antimuscarinic Discontinuation in Patients with Overactive Bladder in Nursing Homes: A Retrospective Study of Medicare Beneficiaries
IntroductionAlthough antimuscarinics form the first-line therapy in overactive bladder (OAB), little is known regarding antimuscarinic...
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Relief of double-J stent-related symptoms: a comparison between mirabegron, tamsulosin and solifenacin
BackgroundInserting ureteral stents is a routine intervention that often results in problems. The cornerstone for treating stent-related symptoms is...
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Risk of Mortality Associated with Non-selective Antimuscarinic medications in Older Adults with Dementia: a Retrospective Study
BackgroundSelective antimuscarinics may offer a favorable safety profile over non-selective antimuscarinics for the management of overactive bladder...
