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Antimicrobial Resistance in Ventilator-Associated Pneumonia: Predictive Microbiology and Evidence-Based Therapy
Ventilator-associated pneumonia (VAP) is a serious intensive care unit (ICU)-related infection in mechanically ventilated patients that is frequent,...
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The effects of delayed appropriate antimicrobial therapy on children with Staphylococcus aureus blood infection
Early appropriate antimicrobial therapy plays a critical role for patients with Staphylococcus aureus bloodstream infection (SAB). We aim to...
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Effectiveness of laser pulsed irradiation for antimicrobial photodynamic therapy
The aim of this study was to compare two types of light irradiation devices for antimicrobial photodynamic therapy (aPDT). A 660-nm light-emitting...
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Association of Papacarie Duo® and low-level laser in antimicrobial photodynamic therapy (aPDT)
Dental caries is a multifactorial, non-communicable disease. Effective treatment options for minimally invasive removal of carious tissue include...
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Recent Updates in Antimicrobial Stewardship in Outpatient Parenteral Antimicrobial Therapy
Purpose of ReviewAntimicrobial stewardship within acute care is common and has been expanding to outpatient areas. Some inpatient antimicrobial...
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Antimicrobial therapy of community-acquired pneumonia during stewardship efforts and a coronavirus pandemic: an observational study
BackgroundCommunity-acquired pneumonia (CAP) is the most frequent infection diagnosis in hospitals. Antimicrobial therapy for CAP is depicted in...
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The impact of immunosuppressive therapy on secondary infections and antimicrobial use in COVID-19 inpatients: a retrospective cohort study
BackgroundImmunosuppressive therapies have become a cornerstone of the management of severe COVID-19. The impact of these therapies on secondary...
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Complex Outpatient Antimicrobial Therapy: Alternative Management Strategies and Outcomes
Purpose of ReviewOutpatient parenteral antibiotic therapy (OPAT) faces challenges requiring alternative solutions to long-term OPAT and skilled...
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Improving antimicrobial treatment in terms of antimicrobial stewardship and health costs by an OPAT service
PurposeOutpatient parenteral antimicrobial therapy (OPAT) is a standard for antimicrobial therapy internationally. With this prospective cohort...
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Exploring patients’ perspectives: a mixed methods study on Outpatient Parenteral Antimicrobial Therapy (OPAT) experiences
BackgroundOutpatient Parenteral Antimicrobial Therapy (OPAT), an alternative to inpatient intravenous antibiotic therapy, has shown benefits in...
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A Randomized, Open-Label, Non-inferiority Clinical Trial Assessing 7 Versus 14 Days of Antimicrobial Therapy for Severe Multidrug-Resistant Gram-Negative Bacterial Infections: The OPTIMISE Trial Protocol
IntroductionShorter courses of antimicrobials have been shown to be non-inferior to longer, “traditional” duration of therapies, including for some...
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Effect of appropriate empirical antimicrobial therapy on mortality of patients with Gram-negative bloodstream infections: a retrospective cohort study
BackgroundLittle evidence exists regarding the prevalence of pathogens in bloodstream infections (BSIs), the mortality risk, and the benefit of...
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Reducing antimicrobial overuse through targeted therapy for patients with community-acquired pneumonia: a study protocol for a cluster-randomized factorial controlled trial (CARE-CAP)
BackgroundCommunity-acquired pneumonia (CAP) is a significant public health concern and a leading cause of hospitalization and inpatient...
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Variations in irradiation energy and rose bengal concentration for photodynamic antimicrobial therapy of fungal keratitis isolates
The purpose is to assess the efficacy of rose bengal photodynamic antimicrobial therapy (PDAT) using different irradiation energy levels and...
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Antimicrobial photodynamic therapy in the nonsurgical treatment of periodontitis in patients with HIV infection: a systematic review and meta-analysis
The aim of this systematic review and meta-analysis (SRM) was to evaluate the effectiveness of the adjunctive use of antimicrobial photodynamic...
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Identification of microorganisms by a rapid PCR panel from positive blood cultures leads to faster optimal antimicrobial therapy – a before-after study
BackgroundThe BioFire® FilmArray® Blood Culture Identification Panel 1 (BF-FA-BCIP) detects microorganisms with high accuracy in positive blood...
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Evaluation of the effects of different photosensitizers used in antimicrobial photodynamic therapy on tooth discoloration: spectrophotometric analysis
BackgroundTooth discoloration is a common concern in antimicrobial photodynamic therapy (aPDT) using various photosensitizers (PS). Toluidine Blue...
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Clinical characteristics and antimicrobial therapy of healthcare-associated carbapenem-non-susceptible gram-negative bacterial meningitis: a 16-year retrospective cohort study
ObjectiveHealthcare-associated Gram-negative bacterial meningitis is a substantial clinical issue with poor outcomes, especially for neurosurgical...
