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Effects of ebselen addition on emotional processing and brain neurochemistry in depressed patients unresponsive to antidepressant medication
Lithium is an effective augmenting agent for depressed patients with inadequate response to standard antidepressant therapy, but numerous adverse...
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Exploring the prevalence of antidepressant medication discontinuation among pregnant veterans
US female veterans have higher rates of mental health (MH) disorders compared to US civilian females and, consequently, are at risk for poor MH...
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Initiating Antidepressant Medication: What is the Most Important Factor?
Treatment initiation is arguably the most important step in the management of depression. It is important at this stage of treatment to establish a...
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Discontinuation of psychotropic medication: a synthesis of evidence across medication classes
Pharmacotherapy is an effective treatment modality across psychiatric disorders. Nevertheless, many patients discontinue their medication at some...
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Pathways into single motherhood, re-partnering, and trajectories of antidepressant medication purchases
Single motherhood is known to be distressing, and to be associated with poor mental health. However, less is known about the pathways into and out of...
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Antidepressant Medication Status as a Moderator of Winter Depression Recurrence Following Cognitive-Behavioral Therapy and Light Therapy: Is There Evidence of an Iatrogenic Effect?
Hollon (Am Psychol 75(9):1207–1218, 2020) questioned whether antidepressant medication (ADM) has iatrogenic effects that prolong a depressive...
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Social determinants of antidepressant continuation during pregnancy in the USA: findings from the ABCD cohort study
PurposePatients and healthcare professionals overestimate the risks of using antidepressants during pregnancy. According to current literature,...
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Antidepressant nonadherence and sexual dysfunction among young adult males: the cross-sectional YAMAN study
PurposeSelective serotonin reuptake inhibitors are associated with high rates of nonadherence and sexual dysfunction, yet the correlation between...
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Prediction of early improvement of major depressive disorder to antidepressant medication in adolescents with radiomics analysis after ComBat harmonization based on multiscale structural MRI
BackgroundDue to individual differences and lack of objective biomarkers, only 30-40% patients with major depressive disorder (MDD) achieve remission...
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Are higher antidepressant plasma concentrations associated with fall risk in older antidepressant users?
PurposeAntidepressants are well-established fall-risk increasing drugs (FRIDs) and therefore falls should be considered an important adverse drug...
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Impact of antidepressant use on post-operative weight loss following bariatric surgery
BackgroundAntidepressant medication can be associated with weight gain. Consideration should be given to the specific agent prescribed to optimize...
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Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder
There is increasing interest in individualizing treatment selection for more than 25 regulatory approved treatments for major depressive disorder...
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Association between maternal antidepressant use during pregnancy and the risk of autism spectrum disorder and attention deficit hyperactivity disorder in offspring
Prenatal antidepressant exposure has been reported to be associated with adverse neurodevelopmental outcomes, yet studies considering confounding...
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Painful physical symptoms and antidepressant treatment outcome in depression: a systematic review and meta-analysis
BackgroundPainful physical symptoms (PPS) are highly prevalent in patients with major depressive disorder (MDD). Presence of PPS in depressed...
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Antidepressant medication prescribing patterns in Irish general practice from 2016 to 2020 to assess for long-term use
Background/aimsThe aim of this study was to identify the trends in antidepressant (AD) medication use in two Irish general practices over a 5-year...
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An assessment of the reporting of tapering methods in antidepressant discontinuation trials using the TIDieR checklist
BackgroundThe importance of tapering is increasingly recognised when discontinuing antidepressant medication. However, no previous studies have...
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The Association Between Antidepressant Use and Drug-Induced Liver Injury: A Nationwide, Population-Based Case–Control Study in Taiwan
Background and ObjectiveThe complex risk factors of liver injury have prevented the establishment of causal relationships. This study aimed to...
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Efficacy of non-invasive brain stimulation combined with antidepressant medications for depression: a systematic review and meta-analysis of randomized controlled trials
BackgroundAntidepressants, noninvasive brain stimulation (NIBS), and their combination are commonly used in routine clinical practice. Nevertheless,...
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Identification of Medication-Related Risks in Bariatric Surgery Patients by Performing Structured Medication Reviews
PurposeMore medication-related issues are seen with the growing demand for bariatric surgery, because of possible altered pharmacokinetics after...
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Estimating Risk of Antidepressant Withdrawal from a Review of Published Data
Adaptation of the brain to the presence of a drug predicts withdrawal on cessation. The outcome of adaptation is often referred to as ‘physical...
