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Standard operating procedure for idarucizumab reversal of dabigatran anticoagulation in ischemic and hemorrhagic stroke
Background: Reversal of dabigatran anticoagulation activity using idarucizumab is indicated for individuals suffering from life-threatening or...
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Andexanet alpha versus four-factor prothrombin complex concentrate in DOACs anticoagulation reversal: an updated systematic review and meta-analysis
BackgroundThere is currently a lack of evidence for the comparative effectiveness of Andexanet alpha and four-factor prothrombin complex concentrate...
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Standardizing periprocedural anticoagulation management: a stewardship initiative
BackgroundStudy data indicates anticoagulant interruption peri-procedurally can increase the risk of anticoagulation-related bleeding and thrombosis....
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Impact of a pharmacist driven anticoagulation reversal program at a large academic medical center
In major/life-threatening bleeding, administration of timely and appropriate reversal agents is imperative to reduce morbidity and mortality. Due to...
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Between a rock and a hard place: anticoagulation management for ECMO
Anticoagulation is an essential component of optimal extracorporeal membrane oxygenation (ECMO) management. Unfractionated heparin is still the...
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Anticoagulation and bleeding in the cancer patient
Cancer patients have an increased risk of bleeding compared to non-cancer patients with anticoagulant therapy. A bleeding risk assessment before...
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SOP: thrombolysis in ischemic stroke under oral anticoagulation therapy
IntroductionBased on demographical trends and the expected worldwide increase in the number of individuals with atrial fibrillation, the rate of...
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Reversal and resumption of anticoagulants in patients with anticoagulant-associated intracerebral hemorrhage
The use of anticoagulants has become more frequent due to the progressive aging population and increased thromboembolic events. Consequently, the...
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When and How to Use Reversal Agents for Direct Oral Anticoagulants?
Purpose of ReviewOur objective is to describe currently available reversal agents for direct oral anticoagulants (DOACs), their target population,...
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Retrospective review of Andexanet Alfa versus 4-Factor Prothrombin Complex Concentrate for reversal of DOAC-Associated Intracranial Hemorrhage
Background : Mortality of oral anticoagulation-associated ICH is around 60%, with oral anticoagulation increasing the risk of ICH seven to ten-fold...
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Anticoagulation strategies and clinical outcomes after bleeding events during anticoagulation therapy for venous thromboembolism in the practice-based Japanese registry
There is a paucity of data on anticoagulation strategies and clinical outcomes after bleeding events for venous thromboembolism (VTE). In a...
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A safe and effective protocol for postdilution hemofiltration with regional citrate anticoagulation
BackgroundRegional citrate anticoagulation (RCA) is recommended during continuous renal replacement therapy. Compared to systemic anticoagulation,...
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The outcomes of three-factor prothrombin complex concentrate (3F-PCC) in warfarin anticoagulation reversal: a prospective, single-arm, open-label, multicentre study
There is a wide variation on the efficacy of three-factor Prothrombin Complex Concentrate (3F-PCC) in warfarin reversal. We aimed to determine the...
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Anticoagulation options for continuous renal replacement therapy in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials
BackgroundContinuous renal replacement therapy (CRRT) is a widely used standard therapy for critically ill patients with acute kidney injury (AKI)....
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Safety and efficacy of prothrombin complex concentrate (PCC) for anticoagulation reversal in patients undergoing urgent neurosurgical procedures: a systematic review and metaanalysis
Anticoagulant therapy poses a significant risk for patients undergoing emergency neurosurgery procedures, necessitating reversal with prothrombin...
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Heparin reversal with protamine sulfate after Percutaneous Hepatic Perfusion (PHP): is less more?
PurposePercutaneous hepatic perfusion (PHP) is a palliative intraarterial therapy for unresectable hepatic malignancies. During PHP, high-dose...
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Idarucizumab for Emergency Reversal of the Anticoagulant Effects of Dabigatran: Final Results of a Japanese Postmarketing Surveillance Study
IntroductionIdarucizumab, a monoclonal antibody fragment that rapidly reverses the anticoagulant effects of dabigatran, was approved in Japan in...
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Assessing the impact of different heparin dosing regimens for cardiopulmonary bypass on anticoagulation: the HepDOSE pilot study
PurposeIt has been suggested that a larger heparin dose during cardiopulmonary bypass (CPB) is associated with reduced perioperative coagulopathy and...
