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Anticholinergic Burden and Cognitive Impairment in Nursing Homes: A Comparison of Four Anticholinergic Scales
BackgroundMedications with anticholinergic effects are commonly used in nursing homes, and their cumulative effect is of particular concern for the...
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Development of the Swedish anticholinergic burden scale (Swe-ABS)
BackgroundDrugs with anticholinergic properties are associated with cognitive adverse effects, especially in patients vulnerable to central...
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Low-Income Older Adults’ Vulnerability to Anticholinergic Medication-Associated Frailty
BackgroundA growing body of research supports the negative impact of anticholinergic drug burden on physical frailty. However, prior research has...
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Cumulative Anticholinergic Burden and its Predictors among Older Adults with Alzheimer’s Disease Initiating Cholinesterase Inhibitors
BackgroundCumulative anticholinergic burden refers to the cumulative effect of multiple medications with anticholinergic properties. However,...
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Development and Pilot Testing of an Algorithm-Based Approach to Anticholinergic Deprescribing in Older Patients
BackgroundAdverse anticholinergic drug reactions are common, yet evidence on how to reduce exposure to anticholinergic activity and reliably measure...
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The relationship between dry eye disease and anticholinergic burden
PurposeAnticholinergic drugs are widely prescribed for many medical conditions. However, data on the association of anticholinergic burden with dry...
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The Prognostic Utility of Anticholinergic Burden Scales: An Integrative Review and Gap Analysis
BackgroundAnticholinergic drugs are commonly prescribed, especially to older adults. Anticholinergic burden scales (ABS) have been used to evaluate...
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Clinical pharmacist-led assessment and management of anticholinergic burden and fall risk in geriatric patients
BackgroundThe aim of this study was to examine the risk of fall with the surrogate outcome of the Aachen Falls Prevention Scale and to assess the...
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Associations Between Midlife Anticholinergic Medication Use and Subsequent Cognitive Decline: A British Birth Cohort Study
BackgroundAnticholinergic medication use is associated with cognitive decline and incident dementia. Our study, a prospective birth cohort analysis,...
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An Evidence-Based Update on Anticholinergic Use for Drug-Induced Movement Disorders
Drug-induced movement disorders (DIMDs) are associated with use of dopamine receptor blocking agents (DRBAs), including antipsychotics. The most...
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Anticholinergic Use for OAB in the Older Woman: An Update
PurposeThis expert narrative review discusses the role of anticholinergic therapy for overactive bladder in older women with a focus on recent...
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Disentangling drug contributions: anticholinergic burden in older adults linked to individual medications: a cross-sectional population-based study
BackgroundMedications with potent anticholinergic properties have well-documented adverse effects. A high cumulative anticholinergic burden may arise...
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Exploring the impact of anticholinergic burden on urinary independence: insights from a post-stroke cohort of older adults
BackgroundAnticholinergic burden is associated with adverse events in the older adults. However, there is a lack of evidence regarding its effect on...
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The association between anticholinergic burden and mobility: a systematic review and meta-analyses
BackgroundAs people age, they accumulate several health conditions, requiring the use of multiple medications (polypharmacy) to treat them. One of...
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Patient and Clinician Challenges with Anticholinergic Step Therapy in the Treatment of Overactive Bladder: A Narrative Review
Anticholinergics have been used in the treatment of overactive bladder (OAB), but their use is limited by poor tolerability and...
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Anticholinergic Burden in Patients Treated for Overactive Bladder: Second-Line Therapy with Tibial Nerve Stimulation as a Solution
Overactive bladder (OAB) is a highly prevalent condition with significant associated comorbidities. Current management guidelines suggest the...
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Seminal papers in urology: anticholinergic therapy vs. onabotulinumtoxina for urgency urinary incontinence
In this critical review, we explore the study design, strengths, and limitations of landmark trial “Anticholinergic therapy vs. onabotulinumtoxinA...
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Overactive Bladder Medication Prescribing Trends in the Era of Known Cognitive Effects from Anticholinergic Drugs
Purpose of ReviewTo review recent global trends in the prescribing of anticholinergic medications for overactive bladder (OAB) and the potential...
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Anticholinergic drugs for parkinsonism and other movement disorders
Anticholinergic (AC) drugs, a medication class that acts by blocking nicotinic and muscarinic acetylcholine receptors, were first utilized for...
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Effects of antipsychotic and anticholinergic medications on cognition in chronic patients with schizophrenia
BackgroundPatients with psychosis frequently use a variety of psychotropic medicines, many of which have anticholinergic effects that can impair...
