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Ten open questions in migraine prophylaxis with monoclonal antibodies blocking the calcitonin-gene related peptide pathway: a narrative review
The monoclonal antibodies (mAbs) blocking the calcitonin-gene related peptide (CGRP) pathway, collectively called here “anti-CGRP/rec mAbs”, have...
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COVID-19 and MIS-C treatment in children—results from an international survey
Children have been mostly excluded from COVID-19 clinical trials, and, as a result, most medicines approved for COVID-19 have no pediatric...
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Functional effects of immune complexes formed between pembrolizumab and patient-generated anti-drug antibodies
The PD-1-targeting IgG 4 antibody pembrolizumab has significant anti-tumor activity in a proportion of stage IV melanoma patients. A subset of...
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Translating B cell immunology to the treatment of antibody-mediated allograft rejection
Antibody-mediated rejection (AMR), including chronic AMR (cAMR), causes ~50% of kidney allograft losses each year. Despite attempts to develop...
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Respiratory Syncytial Virus Infection: An Update
Respiratory syncytial virus (RSV) is a highly contagious respiratory virus that can cause mild to severe illness in children. It is the leading cause...
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Managing Waldenström’s macroglobulinemia with BTK inhibitors
Bruton’s tyrosine kinase (BTK) inhibition is one of the treatment standards for patients with relapsed/refractory Waldenström’s macroglobulinemia...
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Outpatient Management of COVID-19: A Primer for the Dermatologist
Purpose of ReviewTo summarize diagnostic and therapeutic management of COVID-19 in the outpatient setting for dermatologists.
Recent Findings ...
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Evolution of Clinical Care in COVID-Infected Solid Organ Transplant Recipients
Purpose of ReviewIn this review, we aim to summarize the evolution of care for the solid organ transplant recipient (SOTR) with COVID-19 disease,...
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Repressive H3K27me3 drives hyperglycemia-induced oxidative and inflammatory transcriptional programs in human endothelium
BackgroundHistone modifications play a critical role in chromatin remodelling and regulate gene expression in health and disease. Histone...
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The Future of Respiratory Syncytial Virus Disease Prevention and Treatment
Respiratory syncytial virus (RSV) is a major cause of respiratory tract infections in infants, young children, and older or immunocompromised adults....
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Adverse Reactions to Biologic Medications Used in Allergy and Immunology Diseases
Purpose of ReviewThe use of biologic therapies has risen exponentially over recent years, allowing for unprecedented disease control within numerous...
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Cost Effectiveness of Rituximab Therapy for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Cost-Utility Studies
Background and ObjectivesDepletion of B cells is shown to be clinically effective for rheumatoid arthritis (RA) treatment. Although B-cell depletion...
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Lp(a): a New Pathway to Target?
Purpose of ReviewOver the past decades, genetic and observational evidence has positioned lipoprotein(a) as novel important and independent risk...
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The role of minimal residual disease and serum free light chain ratio in the management of multiple myeloma
Multiple myeloma (MM) denotes a cancerous growth characterized by abnormal proliferation of plasma cells. Growing evidence suggests that the...
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Recent Advances in the Management of Cluster Headache
Purpose of reviewAmong the spectrum of pain conditions, cluster headache represents one of the most severe. Targeted therapies for cluster headache...
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T-cell-based immunotherapy of acute myeloid leukemia: current concepts and future developments
Acute myeloid leukemia (AML) is a heterogeneous disease linked to a broad spectrum of molecular alterations, and as such, long-term disease control...
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Posterior reversible encephalopathy syndrome and reversible cerebral vasoconstriction syndrome in patients with COVID-19 infection: is there a link? A systematic review and case report analysis
During the SARS-CoV2 pandemic, several cases of Posterior Reversible Encephalopathy Syndrome (PRES) and of Reversible Cerebral Vasoconstriction...
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New pharmacotherapy options for noninfectious posterior uveitis
IntroductionNoninfectious inflammation of the posterior eye segment represents an important cause of visual impairment. It often affects relatively...