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Broad-spectrum antibiotic prophylaxis in tumor and infected orthopedic surgery—the prospective-randomized, microbiologist-blinded, stratified, superiority trials: BAPTIST Trials
BackgroundThe perioperative antibiotic prophylaxis with 1st or 2nd generation cephalosporins is evidence-based in orthopedic surgery. There are,...
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Study protocol: short against long antibiotic therapy for infected orthopedic sites — the randomized-controlled SALATIO trials
BackgroundFew studies address the appropriate duration of post-surgical antibiotic therapy for orthopedic infections; with or without infected...
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Comparative efficacy and optimal duration of first-line antibiotic regimens for acute otitis media in children and adolescents: a systematic review and network meta-analysis of 89 randomized clinical trials
IntroductionAntibiotic use for acute otitis media (AOM) is one of the major sources of antimicrobial resistance. However, the effective minimal...
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Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials
BackgroundThe efficacy of therapeutic drug monitoring (TDM)-based antimicrobial dosing optimization strategies on pharmacokinetics/pharmacodynamics...
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Optimizing responsiveness to feedback about antibiotic prescribing in primary care: protocol for two interrelated randomized implementation trials with embedded process evaluations
BackgroundAudit and feedback (A&F) that shows how health professionals compare to those of their peers, can be an effective intervention to reduce...
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Antibiotic associated diarrhea in outpatient pediatric antibiotic therapy
BackgroundAntibiotic-associated diarrhea is one of the most frequent side effects of antimicrobial therapy. We assessed the epidemiological data of...
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Antibiotic prophylaxis for onabotulinum toxin A injections: systematic review and meta-analysis
Introduction and hypothesisTo our knowledge, there are no evidence-based recommendations regarding the optimal prophylactic antibiotic regimen for...
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Using text and charts to provide social norm feedback to general practices with high overall and high broad-spectrum antibiotic prescribing: a series of national randomised controlled trials
BackgroundSending a social norms feedback letter to general practitioners who are high prescribers of antibiotics has been shown to reduce antibiotic...
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Impact of adherence to procalcitonin antibiotic prescribing guideline recommendations for low procalcitonin levels on antibiotic use
BackgroundThe Procalcitonin Antibiotic Consensus Trial (ProACT) found provision of a procalcitonin antibiotic prescribing guideline to hospital-based...
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Infective Endocarditis Antibiotic Prophylaxis: Review of the Evidence and Guidelines
Purpose of ReviewThe question of antibiotic prophylaxis and its role in prevention of infective endocarditis (IE) remains controversial, with...
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Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis
PurposeEarly recognition and effective treatment of sepsis improves outcomes in critically ill patients. However, antibiotic exposures are frequently...
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Confidence interval of risk difference by different statistical methods and its impact on the study conclusion in antibiotic non-inferiority trials
BackgroundNumerous statistical methods can be used to calculate the confidence interval (CI) of risk differences. There is consensus in previous...
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Antibiotic adherence in dermatologic surgery: a Multicenter prospective cohort study
Understanding patient non-adherence to prescribed antibiotics can inform clinical practices, patient counseling, and antibiotic efficacy study design...
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Peri-operative Antibiotic Prophylaxis in K-Wire Fixation: A Systematic Review and Meta-analysis
IntroductionThere are currently no standardised guidelines on whether antibiotic prophylaxis is required for Kirschner wire (K-wire) fixation to...
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Current and emerging strategies to curb antibiotic-resistant urinary tract infections
Rising rates of antibiotic resistance in uropathogenic bacteria compromise patient outcomes and prolong hospital stays. Consequently, new strategies...
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Overcoming challenges in the economic evaluation of interventions to optimise antibiotic use
Bacteria are becoming increasingly resistant to antibiotics, reducing our ability to treat infections and threatening to undermine modern health...
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Antibiotic Prophylaxis in Reduction Mammaplasty: A Network Meta-Analysis
BackgroundMounting evidence suggests that breast reduction surgery displays higher rates of surgical site infections (SSI) than initially presumed....
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Non-antibiotic interventions for prevention of urinary tract infections in children: a systematic review and meta-analysis of randomized controlled trials
A considerable proportion of children experience a recurrence of urinary tract infection (UTI) following the first episode. While low-dose antibiotic...
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How standardised are antibiotic regimens in otologic surgery?
BackgroundWithin otologic surgery, a paucity of well-controlled studies assessing the use of systemic antibiotic to reduce surgical site infections...
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Antibiotic-loaded cement in total joint arthroplasty: a comprehensive review
This review evaluates the decision-making framework for using antibiotic-loaded cement (ALC) in the management of prosthetic joint infection (PJI)....
