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Bone marrow cells contribute to seven different endothelial cell populations in the heart
Understanding the mechanisms underlying vascular regeneration in the heart is crucial for develo** novel therapeutic strategies for myocardial...
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Soluble Biomarkers for Prediction of Vascular and Gastrointestinal Disease Severity in Patients with Systemic Sclerosis
Purpose of reviewDisease severity biomarkers in patients with systemic sclerosis (SSc) provide an early and noninvasive screening tool to identify...
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Physicochemical and Functional Similarity Assessment Between Proposed Bevacizumab Biosimilar BAT1706 and Reference Bevacizumab
BackgroundBAT1706 is a proposed biosimilar of bevacizumab, a vascular endothelial growth factor A (VEGF-A)-targeting biologic used to treat several...
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What’s Old is New: The Past, Present and Future Role of Thalidomide in the Modern-Day Management of Multiple Myeloma
Immunomodulatory drugs (IMiDs) have become an integral part of therapy for both newly diagnosed and relapsed/refractory multiple myeloma (RRMM)....
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Clinical immunotherapy in pancreatic cancer
Pancreatic cancer remains a challenging disease with limited treatment options, resulting in high mortality rates. The predominant approach to...
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Ovarian, uterine, and luteal vascular perfusions during follicular and luteal phases in the adult cyclic female rabbits with special orientation to their histological detection of hormone receptor
Understanding the does reproductive hemodynamic changes during the estrous cycle is crucial for improving reproductive competence and fertility...
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Minocycline for sporadic and hereditary cerebral amyloid angiopathy (BATMAN): study protocol for a placebo-controlled randomized double-blind trial
BackgroundCerebral amyloid angiopathy (CAA) is a disease caused by the accumulation of the amyloid-beta protein and is a major cause of intracerebral...
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Dental stem cells improve memory and reduce cell death in rat seizure model
Epilepsy is a common neurological disorder that significantly affects the quality of life of patients. In this study, we aim to evaluate the...
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Inflammation and tumor progression: signaling pathways and targeted intervention
Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses tumor progression, potentially...
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Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy
Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours are known as tumour-associated macrophages (TAMs). These...
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A case of hypertensive disorders of pregnancy that developed at 9 weeks of gestation
Preeclampsia and superimposed preeclampsia usually develop after 20 weeks of gestation. We report a case of a 35-year-old Japanese woman who...
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Paraneoplastic syndrome in neuroophthalmology
Paraneoplastic syndrome is a group of clinical symptoms that occur in the state of systemic malignant tumors. Paraneoplastic syndrome of the nervous...
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Anti-asthmatic miR-224-5p inhibits the FHL1/MAPK pathway to repress airway smooth muscle cell proliferation in a murine model of asthma-like airway inflammation
BackgroundThe proliferation of airway smooth muscle cells (ASMCs) contributes to the contractility and inflammation in the pathophysiology of asthma....
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MicroRNA-409-5p Inhibits GIST Tumorigenesis and Improves Imatinib Resistance by Targeting KDM4D Expression
ObjectiveGastrointestinal stromal tumors (GISTs) can rapidly proliferate through angiogenesis. Previous studies indicated the potential influence of...
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The current landscape of using direct inhibitors to target KRASG12C-mutated NSCLC
Mutation in KRAS protooncogene represents one of the most common genetic alterations in NSCLC and has posed a great therapeutic challenge over the...
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The proteomic characterization of the peritumor microenvironment in human hepatocellular carcinoma
The tumor microenvironment (TME) was usually studied in tumor tissue and in relation to only tumor progression, with little involved in occurrence,...
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Emerging Roles of Galectin-3 in Pulmonary Diseases
Galectin-3 is a multifunctional protein that is involved in various physiological and pathological events. Emerging evidence suggests that galectin-3...
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Changes in aqueous and vitreous inflammatory cytokine levels in proliferative diabetic retinopathy: a systematic review and meta-analysis
BackgroundDiabetic retinopathy is a major complication of diabetes mellitus, where in its most advanced form ischemic changes lead to the development...
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CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies
The current standard of care in hematological malignancies has brought considerable clinical benefits to patients. However, important bottlenecks...