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Clinical effect of full endoscopic lumbar annulus fibrosus suture
PurposeThe aim of this study was to investigate the clinical efficacy of full endoscopic lumbar annulus fibrosus suture in the treatment of...
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Celecoxib alleviates nociceptor sensitization mediated by interleukin-1beta-primed annulus fibrosus cells
PurposeThis study aims to analyze the effect of pro-inflammatory cytokine-stimulated human annulus fibrosus cells (hAFCs) on the sensitization of...
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Aberrant mechanical loading induces annulus fibrosus cells apoptosis in intervertebral disc degeneration via mechanosensitive ion channel Piezo1
BackgroundIntervertebral disc degeneration (IVDD) is closely associated with the structural damage in the annulus fibrosus (AF). Aberrant mechanical...
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Fibrotic alterations in human annulus fibrosus correlate with progression of intervertebral disc herniation
BackgroundIntervertebral disc (IVD) herniation is characterized by annulus fibrosus failure (AF) in containing the nucleus pulposus (NP). IVD...
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Radial trend in murine annulus fibrosus fiber orientation is best explained by vertebral growth
PurposeThe intervertebral disc (IVD) annulus fibrosus (AF) is composed of concentric lamellae with alternating right- and left-handed helically...
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Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs
BackgroundIntervertebral disc degeneration contributes to low back pain. The avascular intervertebral disc consists of a central hypoxic nucleus...
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Diffusion properties of asymptomatic lumbar intervertebral discs in a pediatric cohort: a preliminary study of apparent diffusion coefficient
PurposeTo explore the apparent diffusion coefficients of intervertebral discs in an asymptomatic pediatric cohort.
MethodsWe conducted a prospective...
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GREM1, LRPPRC and SLC39A4 as potential biomarkers of intervertebral disc degeneration: a bioinformatics analysis based on multiple microarray and single-cell sequencing data
BackgroundLow back pain (LBP) has drawn much widespread attention and is a major global health concern. In this field, intervertebral disc...
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Ultrashort time-to-echo T2* and T2* relaxometry for evaluation of lumbar disc degeneration: a comparative study
BackgroundTo compare potential of ultrashort time-to-echo (UTE) T2* map** and T2* values from T2*-weighted imaging for assessing lumbar...
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The most influential articles on stem cells in intervertebral disc degeneration
BackgroundStem cell-related studies have been increasingly conducted to facilitate the regeneration of degenerative discs. However, analyses of...
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The relationship between structural changes in paraspinal muscles and intervertebral disc and facet joint degeneration in the lumbar spine of rats
BackgroundDegenerative spine disease is one of the largest causes of disability worldwide and has a multifactorial aetiology. Determining the leading...
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ISSLS PRIZE in Basic Science 2024: superiority of nucleus pulposus cell- versus mesenchymal stromal cell-derived extracellular vesicles in attenuating disc degeneration and alleviating pain
PurposeTo investigate the therapeutic potential of extracellular vesicles (EVs) derived from human nucleus pulposus cells (NPCs), with a specific...
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MiR-206 improves intervertebral disk degeneration by targeting GJA1
BackgroundA large amount of evidence suggested that miRNA was involved in the progression of intervertebral disk degeneration (IDD). The purpose of...
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Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs
A comprehensive understanding of the cellular heterogeneity and molecular mechanisms underlying the development, homeostasis, and disease of human...
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Advancing skeletal health and disease research with single-cell RNA sequencing
Orthopedic conditions have emerged as global health concerns, impacting approximately 1.7 billion individuals worldwide. However, the limited...
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T1ρ, T2 and T2* map** of lumbar intervertebral disc degeneration: a comparison study
BackgroundEarly and accurate assessment of lumbar intervertebral disc degeneration (IVDD) is very important to therapeutic strategy. This study aims...
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Potential molecular targets and drugs for basement membranes-related intervertebral disk degeneration through bioinformatics analysis and molecular docking
BackgroundThrough bioinformatics analysis to identify the hub genes of Intervertebral disc degeneration (IVDD) associated with basement membranes...
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Regenerating and repairing degenerative intervertebral discs by regulating the micro/nano environment of degenerative bony endplates based on low-tension mechanics
BackgroundConservative treatment is the recommended first-line treatment for degenerative disc diseases. Traction therapy has historically been one...
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TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway
BackgroundThe aim of this study is to explore the effects of TGF-β1 on autophagy and apoptosis induced by exogenous hydrogen peroxide (H 2 O 2 ) in...
