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Prediction of pandemic risk for animal-origin coronavirus using a deep learning method
BackgroundCoronaviruses can be isolated from bats, civets, pangolins, birds and other wild animals. As an animal-origin pathogen, coronavirus can...
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Antigen epitopes of animal coronaviruses: a mini-review
Coronaviruses are widespread in nature and can infect mammals and poultry, making them a public health concern. Globally, prevention and control of...
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Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential anti pan-coronavirus activity
Emerging and recurrent infectious diseases caused by human coronaviruses (HCoVs) continue to pose a significant threat to global public health...
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Neurovirulent cytokines increase neuronal excitability in a model of coronavirus-induced neuroinflammation
BackgroundNeurological manifestations of severe coronavirus infections, including SARS-CoV-2, are wide-ranging and may persist following virus...
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Decoding bovine coronavirus immune targets: an epitope informatics approach
Bovine coronavirus (BCoV) poses a significant threat to the global cattle industry, causing both respiratory and gastrointestinal infections in...
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Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1
Respiratory disease caused by coronavirus infection remains a global health crisis. Although several SARS-CoV-2-specific vaccines and direct-acting...
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Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke
The Coronavirus disease 2019 (COVID-19) epidemic has triggered a huge impact on healthcare, socioeconomics, and other aspects of the world over the...
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Late diagnosis of respiratory syncytial virus and influenza co-infection during coronavirus disease 2019 pandemic: a case report
BackgroundRespiratory syncytial virus (RSV)-induced disease is one of the important causes of flu-like illness in older adults and can cause serious...
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Neurons cytoskeletal architecture remodeling during the replication cycle of mouse coronavirus MHV-JHM: a morphological in vitro study
Nowadays, the population is still struggling with a post-COVID19 syndrome known as long COVID, including a broad spectrum of neurological problems....
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Evaluation of bovine coronavirus in Korean native calves challenged through different inoculation routes
Bovine coronavirus (BCoV) is a pneumoenteric virus that can infect the digestive and respiratory tracts of cattle, resulting in economic losses....
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Quercetin inhibition of porcine intestinal alpha coronavirus in vitro and in vivo
BackgroundPorcine acute diarrhea syndrome coronavirus (SADS-CoV) is one of the novel pathogens responsible for piglet diarrhea, contributing to...
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Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation
Excessive inflammatory responses contribute to the pathogenesis and lethality of highly pathogenic human coronaviruses, but the underlying mechanism...
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Swine acute diarrhea syndrome coronavirus nucleocapsid protein antagonizes the IFN response through inhibiting TRIM25 oligomerization and functional activation of RIG-I/TRIM25
Swine acute diarrhea syndrome coronavirus (SADS-CoV), an emerging Alpha-coronavirus , brings huge economic loss in swine industry. Interferons (IFNs)...
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Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has...
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Early use of airway pressure release ventilation in acute respiratory distress syndrome induced by coronavirus disease 2019: a case report
BackgroundCoronavirus disease 2019 is a highly transmissible and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus...
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A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections
We aimed to investigate the safety and efficacy of nirmatrelvir/ritonavir (Paxlovid) therapy for hemodialysis-dependent patients with severe acute...
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A longitudinal study of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels
BackgroundMiddle East respiratory syndrome coronavirus (MERS-CoV) was identified in humans in 2012. Since then, 2605 cases and 937 associated deaths...
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Systems pharmacology dissection of pharmacological mechanisms of **aochaihu decoction against human coronavirus
BackgroundAlthough coronavirus disease 2019 (COVID-19) pandemic is still rage worldwide, there are still very limited treatments for human...
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Changes in intestinal morphology, number of mucus-producing cells and expression of coronavirus receptors APN, DPP4, ACE2 and TMPRSS2 in pigs with aging
Porcine enteric viral infections cause high morbidity and mortality in young piglets (<3 weeks). Later, these rates decrease with age. This...
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Acute kidney injury due to myoglobin cast nephropathy in the setting of coronavirus disease 2019-mediated rhabdomyolysis: a case report
BackgroundWe present this case of coronavirus disease 2019-associated acute kidney injury with rhabdomyolysis—with noteworthy renal biopsy findings...
