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Eutectic mixture of local anesthetics and amethocaine as topical anesthetics in pediatrics: a meta-analysis
BackgroundPediatric patients often receive topical anesthesia before skin procedures in the Emergency Department, with EMLA cream and amethocaine gel...
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Neurosteroids and their potential as a safer class of general anesthetics
Neurosteroids (NS) are a class of steroids that are synthesized within the central nervous system (CNS). Various NS can either enhance or inhibit CNS...
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Anesthesia, Anesthetics, and Postoperative Cognitive Dysfunction in Elderly Patients
Postoperative cognitive dysfunction (POCD) remains a major issue that worsens the prognosis of elderly surgery patients. This article reviews the...
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Effects of volatile anesthetics on circadian rhythm in mice: a comparative study of sevoflurane, desflurane, and isoflurane
PurposeVolatile anesthetics affect the circadian rhythm of mammals, although the effects of different types of anesthetics are unclear. Here, we...
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Effects of anesthetics on nociceptive sensory evoked potentials by intraepidermal noxious electrical stimulation of A-δ fibers
PurposeGeneration of nociceptive sensory evoked potentials (NEPs) by selective stimulation of nociceptive intraepidermal nerve fibers is a simple...
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Effect of species, concentration and volume of local anesthetics on intervertebral disk degeneration in rats with discoblock
PurposeDiscoblock is effective in relieving discogenic low back pain, but it can also cause intervertebral disk degeneration (IDD). The effect of...
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Safety of local anesthetics in cervical nerve root injections: a narrative review
Severe neurological adverse events have been reported after fluoroscopically guided cervical nerve root injections. Particulate corticosteroids...
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Two cases of anesthetics-induced epileptic seizures: a case report and literature review
BackgroundAnesthetics like propofol have been reported to be capable of controlling status epilepticus. However, we have observed during daily...
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Safe sedation management using volatile anesthetics during cardiopulmonary bypass
Several pieces of evidence suggest that volatile anesthetics (VAs), which were originally used as sedatives, have myocardial protective effects...
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Volatile Versus Intravenous Anesthetics in Cardiac Anesthesia: a Narrative Review
Purpose of the ReviewThe present review addresses clinicians and gives an overview about the experimental rationale for pharmacological conditioning...
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Effects of anesthetics on expression of dopamine and acetylcholine receptors in the rat brain in vivo
Dopamine D 2 and acetylcholine M 1 receptors might be related to post-operative cognitive dysfunction. The aim of the present study is to investigate...
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Volatile anesthetics maintain tidal volume and minute ventilation to a greater degree than propofol under spontaneous respiration
BackgroundAlthough general anesthetics depress spontaneous respiration, the comprehensive effect of general anesthetics on respiratory function...
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Local anesthetics systemic toxicity in children: analysis of the French pharmacovigilance database
PurposeTo characterize clinical profile of pediatric local anesthetic (LA) systemic toxicity (LAST) and to identify determinants of life-threatening...
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Allergy to Local Anesthetics is a Rarity: Review of Diagnostics and Strategies for Clinical Management
Local anesthetics (LA) are commonly used in procedures and in topical agents for pain management. With the increasing use of LA drugs, the management...
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Commonly used anesthetics modify alcohol and (-)-trans-delta9-tetrahydrocannabinol in vivo effects on rat cerebral arterioles
BackgroundEthyl alcohol and cannabis are widely used recreational substances with distinct effects on the brain. These drugs increase accidental...
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General Anesthetics in CAncer REsection Surgery (GA-CARES) randomized multicenter trial of propofol vs volatile inhalational anesthesia: protocol description
BackgroundStudies indicate that patients can be “seeded” with their own cancer cells during oncologic surgery and that the immune response to these...
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The effect and safety of dexmedetomidine as an adjuvant to local anesthetics in erector spinae plane block: a systematic review and meta-analysis of randomized controlled trials
BackgroundDexmedetomidine (DEX) has been thought to be an effective adjuvant to local anesthetics (LAs) in erector spinae plane block (ESPB),...
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Anesthetics may modulate cancer surgical outcome: a possible role of miRNAs regulation
BackgroundmicroRNAs (miRNAs) are single-stranded and noncoding RNA molecules that control post-transcriptional gene regulation. miRNAs can be tumor...
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Effect of Intraperitoneal Local Anesthetics in Laparoscopic Bariatric Surgery: A Meta-Analysis of Randomized Controlled Trials
ObjectiveThe effectiveness of intraperitoneal local anesthesia (IPLA) has been confirmed in other fields, but its use in bariatric surgery remains...
