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Preliminary investigation of potential links between pigmentation variants and opioid analgesic effectiveness in horses during cerebrospinal fluid centesis
BackgroundThe pleiotropic effects of the melanocortin system show promise in overcoming limitations associated with large variations in opioid...
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The cost-effectiveness analysis of analgesic treatment options for postoperative pain following laparotomy surgeries
BackgroundPostoperative pain control remains unsatisfactory. Patients who underwent laparotomy may have moderate to severe acute postoperative pain....
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To evaluate the analgesic effectiveness of bilateral erector spinae plane block versus thoracic epidural analgesia in open cardiac surgeries approached through midline sternotomy
BackgroundThe efficacy of the erector spinae plane (ESP) block in mitigating postoperative pain has been shown for a range of thoracic and abdominal...
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Evaluation of the effectiveness of analgesia nociception index (ANI) predictability for surgical stimuli under personal analgesic sufficiency status (PASS) measured by pre-tetanus-induced ANI: a pilot study
The Analgesia Nociception Index (ANI) is a promising monitor to evaluate the balance of nociception and anti-nociception based on heart rate...
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Analgesic effectiveness of serratus anterior plane block in patients undergoing video-assisted thoracoscopic surgery: a systematic review and updated meta-analysis of randomized controlled trials
BackgroundSerratus anterior plane block (SAPB) is a promising regional technique for analgesia in thoracic surgery. Till now, several randomized...
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Comparison of analgesic effectiveness between nefopam and propacetamol in living kidney donors following rectus sheath block after hand-assisted living donor nephrectomy: a prospective, randomized controlled trial
BackgroundNefopam and propacetamol are the most commonly used analgesics in postoperative multimodal analgesic regimens. Distinct mechanisms are...
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Rescue designs in analgesic trials from 0 to 2 years of age: sco** review
AbstractPediatric analgesic trials are challenging, especially in newborns and infants. Following an FDA-academic consensus meeting, we analyzed...
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Postoperative analgesic effectiveness of quadratus lumborum block: systematic review and meta-analysis for adult patients undergoing hip surgery
BackgroundQuadratus lumborum block is a truncal block with several technique variations. It has been reported as providing effective analgesia for...
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Analgesic options for anterior approach to scoliosis repair: a sco** review
PurposeThe ideal analgesic regimen for the anterior approach to scoliosis repair is not clearly defined. The purpose of the study was to summarize...
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Optimal analgesic regimen for total shoulder arthroplasty: a randomized controlled trial and network meta-analysis
ObjectiveClinical approaches to analgesia following total shoulder arthroplasty include liposomal bupivacaine, local infiltration analgesia,...
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Analgesic Effectiveness of Truncal Plane Blocks in Patients Undergoing the Nuss Procedure: A Randomized Controlled Trial
IntroductionMost patients undergoing the Nuss procedure reported moderate to severe pain after surgery. This study aimed to investigate the efficacy...
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Analgesic Techniques for Rib Fractures—A Comprehensive Review Article
Purpose of ReviewRib fractures are a common traumatic injury that has been traditionally treated with systemic opioids and non-opioid analgesics. Due...
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Prospective preference assessment for the Comparison of Analgesic Regimen Effectiveness and Safety in Surgery (CARES) trial
BackgroundClinical trials face major barriers such as under-enrollment and selective enrollment, which threaten study completion and undermine...
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The comparison of postoperative analgesic requirements between modified thoracoabdominal nerve block through perichondrial approach versus wound infiltration analgesia in patients undergoing gynecological laparoscopic surgery: a retrospective, exploratory study
IntroductionRecently, modified thoracoabdominal nerve block through perichondrial approach (M-TAPA) has been introduced as a novel trunk block. To...
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Analgesic effects of oral Yokukansan on acute postoperative pain and involvement of the serotonin nervous system: a mouse model study
BackgroundYokukansan, a traditional Japanese medicine (Kampo), has been widely used to treat neurosis, dementia, and chronic pain. Previous in vitro...
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Comparison of analgesic efficacy of ibuprofen and dexketoprofen in pain management of long bone fractures: a prospective, randomized, double-blind study
IntroductionLong bone fractures (LBF) often cause severe pain, impacting patients’ quality of life. This prospective, randomized, double-blind study...
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A randomized controlled trial on the effectiveness of laparoscopic-guided transversus abdominis plane block in patients undergoing laparoscopic IPOM plus
IntroductionVentral hernia repairs, particularly laparoscopic ventral hernia repair (LVHR), have become common procedures among general surgeons...
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Analgesic effect of nitrous oxide during manual therapy after anterior cruciate ligament reconstruction: a study protocol for a randomized controlled trial
BackgroundMany patients during manual therapy after anterior ligament reconstruction will experience severe pain, which has a negative impact on...
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Outcomes of hip fracture treatment with intravenous morphine and with other analgesics: postoperative analgesic medical expense, severity of pain and hospitalisation—a retrospective study
AimsThis study compares the postoperative medical costs and outcomes of hip fracture patients treated with intravenous (IV) versus other analgesics...
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The comparison of the analgesic efficacy of continuous paravertebral block alone compared with continuous paravertebral and intercostal nerve block for thoracotomy in adults: a randomized controlled trial
PurposeThe study aims to compare the analgesic efficacy of two analgesic interventions, continuous paravertebral (PVB) nerve block alone with...
