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Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurological condition characterized by impaired cognitive function and behavioral alterations. While AD...
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Magnetic Resonance Imaging-Negative Cerebral Amyloid Angiopathy: Cerebrospinal Fluid Amyloid-β42 over Amyloid Positron Emission Tomography
BackgroundCerebral amyloid angiopathy (CAA) pathology is becoming increasingly important in Alzheimer’s disease (AD) because of its potential link to...
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Biomarkers associated with coronary high-risk plaques
Vascular inflammation, lipid metabolism, and thrombogenicity play a key role not only in atherogenesis but also in the development of acute coronary...
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Novel insights into presenilin 1 mutation associated with a distinctive dementia phenotype and cotton wool plaques
BackgroundThe mutations in the presenilin 1 gene ( PSEN1 ) are the main cause of familial Alzheimer's disease. PSEN1 mutations affect amyloid-beta...
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Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer’s disease (AD), and its accumulation has been considered as the...
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Amyloid-PET/CT – Überblick und Fallbeispiele
Amyloid positron emission tomography/computed tomography (PET/CT) is a helpful aid in imaging pathological cerebral amyloid deposits and is a proven...
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Amyloid-Lowering Monoclonal Antibodies for the Treatment of Early Alzheimer’s Disease
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Numerous biomarker studies have clearly demonstrated that AD has a long...
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Anti-amyloid Antibody Therapies for Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common cause of dementia, which is characterized by a progressive neurodegenerative disorder that is extremely...
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Vascular Considerations for Amyloid Immunotherapy
Purpose of ReviewAmyloid beta (Aβ) plaque accumulation is a hallmark pathology contributing to Alzheimer’s disease (AD) and is widely hypothesized to...
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Plasma Oligomer β-Amyloid and White Matter Microstructural Integrity in Cognitively Normal Older Adults According to Cerebral Amyloid Deposition
BackgroundMultimer detection system-oligomeric amyloid-β (MDS-OAβ) measure plasma OAβ level, which is associated with earlier Alzheimer’s disease...
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A novel subtype of sporadic Creutzfeldt–Jakob disease with PRNP codon 129MM genotype and PrP plaques
The presence of amyloid kuru plaques is a pathological hallmark of sporadic Creutzfeldt–Jakob disease (sCJD) of the MV2K subtype. Recently, PrP...
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Transmissible long-term neuroprotective and pro-cognitive effects of 1–42 beta-amyloid with A2T icelandic mutation in an Alzheimer’s disease mouse model
The amyloid cascade hypothesis assumes that the development of Alzheimer’s disease (AD) is driven by a self-perpetuating cycle, in which β-amyloid...
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Clarity on the blazing trail: clearing the way for amyloid-removing therapies for Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with a complex pathogenesis. Senile plaques composed of the amyloid-β (Aβ)...
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Prediction of amyloid PET positivity via machine learning algorithms trained with EDTA-based blood amyloid-β oligomerization data
BackgroundThe tendency of amyloid-β to form oligomers in the blood as measured with Multimer Detection System-Oligomeric Amyloid-β (MDS-OAβ) is a...
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Update on Amyloid Polyneuropathy and Treatment
Purpose of ReviewThe purpose of this review is to summarize currently available and develo** diagnostic and treatment options for hereditary...
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Sepsis exacerbates Alzheimer’s disease pathophysiology, modulates the gut microbiome, increases neuroinflammation and amyloid burden
While our understanding of the molecular biology of Alzheimer’s disease (AD) has grown, the etiology of the disease, especially the involvement of...
