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Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse
Social hierarchy has a profound impact on social behavior, reward processing, and mental health. Moreover, lower social rank can lead to chronic...
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Clinical significance of amphiregulin in patients with chronic kidney disease
BackgroundAmphiregulin (AREG) is a ligand of epidermal growth factor receptor (EGFR), which plays an important role in injury-induced kidney...
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Amphiregulin as a novel diagnostic and prognostic biomarker of hepatocellular carcinoma before and after locoregional treatment
BackgroundHepatocellular carcinoma is a highly prevalent tumor worldwide. Amphiregulin is a ligand of the epidermal growth factor receptor. Its...
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Luteinizing hormone stimulates the expression of amphiregulin in human theca cells
BackgroundLuteinizing hormone (LH) can stimulate mural granulosa cells to produce Amphiregulin (AREG), which can induce the resumption of meiosis in...
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Compatibility of intravitreally applied epidermal growth factor and amphiregulin
IntroductionTo examine the compatibility of intravitreally injected epidermal growth factor (EGF) and amphiregulin as EGF family member.
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Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells
BackgroundAirway fibrosis is one of the pathological characteristics of severe asthma. Transforming growth factor (TGF)-β has been known to promote...
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Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53
Ovarian cancer (OvCA) remains one of the most devastating malignancies, but treatment options are still limited. We report that amphiregulin (AREG)...
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A distinct “repair” role of regulatory T cells in fracture healing
Regulatory T cells (Tregs) suppress immune responses and inflammation. Here, we described the distinct nonimmunological role of Tregs in fracture...
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Amphiregulin deletion strongly attenuates the development of estrogen receptor-positive tumors in p53 mutant mice
PurposeThe epidermal growth factor receptor ligand, Amphiregulin, is a transcriptional target of estrogen receptor alpha and is required for pubertal...
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The in-vitro effect of gonadotropins’ type and combination on Granulosa cells gene expressions
ObjectiveNowadays, different modes and timing of GnRH-agonist combined with hCG trigger, for final follicular maturation, have been described. While...
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EGF-like growth factors upregulate pentraxin 3 expression in human granulosa-lutein cells
The epidermal growth factor (EGF)-like factors, comprising amphiregulin (AREG), betacellulin (BTC), and epiregulin (EREG), play a critical role in...
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RNA-seq analysis of human trabecular endothelial cells after treatment with timolol maleate
PurposeTimolol maleate (timolol), a β-receptor blocker, reduces intraocular pressure by decreasing aqueous humor production. Timolol reportedly also...
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Inhibitory Effect of **kui Shenqi Pills on Glucocorticoid-Enhanced Axial Length Elongation in Experimentally Myopic Guinea Pigs
ObjectiveTo explore the underlying mechanism of inhibition by **kui Shenqi Pills (JKSQP) on glucocorticoid-enhanced axial length elongation in...
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Amphiregulin in intestinal acute graft-versus-host disease: a possible diagnostic and prognostic aid
Amphiregulin, a weak epidermal growth factor receptor agonist, is elevated, while epidermal growth factor, a strong epidermal growth factor receptor...
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Increased TSLP, IL-33, IL-25, IL-19, IL 21 and amphiregulin (AREG) levels in chronic rhinosinusitis with nasal polyp
ObjectiveChronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease. The surrogate indicating biomarkers in patients with...
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Endometrial decidualization status modulates endometrial microvascular complexity and trophoblast outgrowth in gelatin methacryloyl hydrogels
The endometrium undergoes rapid cycles of vascular growth, remodeling, and breakdown during the menstrual cycle and pregnancy. Decidualization is an...
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Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging
BackgroundWith advanced maternal age, abnormalities during oocyte meiosis increase significantly. Aneuploidy is an important reason for the reduction...
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