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Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole
Hypersensitivity reactions including IgE-mediated and delayed cell-mediated reactions to aminoglycosides, clindamycin, linezolid, and metronidazole...
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Aminoglycoside-Related Nephrotoxicity and Ototoxicity in Clinical Practice: A Review of Pathophysiological Mechanism and Treatment Options
Aminoglycosides are a class of medications used to treat certain bacterial infections, specifically gram-negative aerobes. These drugs can be used...
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Species identification and drug susceptibility testing of non-tuberculous mycobacteria by Line Probe Assay in Lambaréné, Gabon—a cross-sectional study
BackgroundNon-tuberculous mycobacteria (NTM) are a group of bacteria that cause rare lung infections and are increasingly recognized as causative...
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Ototoxic and nephrotoxic drugs in neonatal intensive care units: results of a Spanish and Italian survey
Neonates face heightened susceptibility to drug toxicity, often exposed to off-label medications with dosages extrapolated from adult or pediatric...
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Efficacy of carbapenem vs non carbapenem β-lactam therapy as empiric antimicrobial therapy in patients with extended-spectrum β-lactamase-producing Enterobacterales urinary septic shock: a propensity-weighted multicenter cohort study
BackgroundThe rise in antimicrobial resistance is a global threat responsible for about 33,000 deaths in 2015 with a particular concern for...
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Antimicrobial utilization and resistance in Pseudomonas aeruginosa using segmented regression analysis: a comparative study between Serbia and eight European Countries
BackgroundIn Europe, Serbia occupies a high position in antibiotic utilization and antimicrobial resistance (AMR).
AimThe aim was to analyse...
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Treatment options for K. pneumoniae, P. aeruginosa and A. baumannii co-resistant to carbapenems, aminoglycosides, polymyxins and tigecycline: an approach based on the mechanisms of resistance to carbapenems
The management of carbapenem-resistant infections is often based on polymyxins, tigecycline, aminoglycosides and their combinations. However, in a...
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Neonatal nephrotoxic medication exposure and early acute kidney injury: results from the AWAKEN study
BackgroundWe aimed to describe nephrotoxic medication exposure and investigate associations between exposure and acute kidney injury (AKI) in the...
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Prevalence and mechanisms of aminoglycoside resistance among drug-resistant Pseudomonas aeruginosa clinical isolates in Iran
BackgroundAminoglycosides have been a cornerstone of the treatment of nosocomial infections caused by Pseudomonas aeruginosa for over 80 years....
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International survey of antibiotic dosing and monitoring in adult intensive care units
BackgroundIn recent years, numerous dosing studies have been conducted to optimize therapeutic antibiotic exposures in patients with serious...
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Optimization of Pediatric Antibiotic Dosing Through Therapeutic Drug Monitoring
Purpose of reviewReview data and provide recommendations on the optimization of antibiotic dosing in pediatrics through therapeutic drug monitoring...
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Assessment of Causality in Hospitalized Children With Aminoglycoside-Related Nephrotoxicity
ObjectivesTo evaluate the incidence of aminoglycoside-related nephrotoxicity and ascertain drug causality and its risk factors.
Methods ... -
Dynamic antimicrobial resistant patterns of Escherichia coli from healthy poultry and swine over 10 years in Chongming Island, Shanghai
BackgroundAntimicrobial resistance (AMR) is one of the greatest threats to animal and public health. Here, we conducted a dynamic surveillance of Esch...
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Ouabain potentiates the antimicrobial activity of aminoglycosides against Staphylococcus aureus
BackgroundStaphylococcus aureus is a notorious pathogen which often causes nosocomial and community attained infections. These infections steadily...
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Clinical characteristics and outcomes in pseudomonas endocarditis: a systematic review of individual cases
BackgroundThe landscape of Pseudomonas infective endocarditis (IE) is evolving with the widespread use of cardiac implantable devices and...
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Aminoglycoside or Polymyxin Monotherapy for Treating Complicated Urinary Tract Infections Caused by Extensively Drug-Resistant Pseudomonas aeruginosa: A Propensity Score-Adjusted and Matched Cohort Study
IntroductionExtensively drug-resistant (XDR) Pseudomonas aeruginosa (PA) infections are difficult to treat. We aimed to compare aminoglycosides or...
