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Amino acid metabolism in health and disease
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth,...
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The amino acid and carnitine concentration changes in bronchoalveolar lavage fluid from lung cancer patients
ObjectiveTo screen out potential biomarkers by analyzing fundamental nutrients in the bronchoalveolar lavage fluid (BALF) before confirming the lung...
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Possible-sarcopenic screening with disturbed plasma amino acid profile in the elderly
BackgroundThe mass and strength of skeletal muscle decline with age, leading to its progressive dysfunction. High-throughput metabolite profiling...
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L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis
Oncometabolites, such as D/L-2-hydroxyglutarate (2HG), have directly been implicated in carcinogenesis; however, the underlying molecular mechanisms...
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Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy
Amino acids are basic nutrients for immune cells during organ development, tissue homeostasis, and the immune response. Regarding metabolic...
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Dietary amino acid patterns and cardiometabolic risk factors among subjects with obesity; a cross-sectional study
BackgroundThe prevalence of obesity is a growing global public health concern. Certain dietary amino acids have been shown to have a potential...
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Guanidine acetic acid supplementation altered plasma and tissue free amino acid profiles in finishing pigs
BackgroundAs a nutritive feed additive, guanidine acetic acid (GAA) participates in the metabolism of energy and proteins. This study aimed to...
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Prognostic value of amino acid metabolism-related gene expression in invasive breast carcinoma
BackgroundAn increasing number of studies indicated that metabolic reprogramming of amino acid metabolism may either promote or inhibit tumor...
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In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters
Background( S )-2-amino-3-[3-(2- 18 F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid ( 18 F-FIMP) as a promising PET probe for imaging the...
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The efficacy of hyaluronic acid fragments with amino acid in combating facial skin aging: an ultrasound and histological study
BackgroundVarious techniques have been employed in aesthetic medicine to combat skin aging, in particular that of the facial region. Hyaluronic acid...
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Tissue and plasma free amino acid detection by LC-MS/MS method in high grade glioma patients
PurposeThe changes in serum amino acid profiles are evaluated in different types of cancers and screening tests were developed for estimating the...
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Acute kidney injury development is associated with mortality in Japanese patients with cirrhosis: impact of amino acid imbalance
BackgroundAcute kidney injury (AKI) is a serious complication of cirrhosis. This study analyzed the prognostic effect of AKI in patients with...
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Amino acid influx via LAT1 regulates iron demand and sensitivity to PPMX-T003 of aggressive natural killer cell leukemia
Aggressive natural killer cell leukemia (ANKL) is a rare hematological malignancy with a fulminant clinical course. Our previous study revealed that...
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Amino acid availability enhanced through glucose coadministration of amino acid supplementation during hemodiafiltration: two case reports
BackgroundIntravenous administration of amino acid (AA) formulation (IVAA) as intradialytic parenteral nutrition is widely used for malnourished...
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Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production
Aim/hypothesisHyperglycaemia is associated with alpha cell dysfunction, leading to dysregulated glucagon secretion in type 1 and type 2 diabetes;...
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High-volume pre-dilution on-line hemodiafiltration is the adequate blood purification method from the viewpoint of amino acid nutrition
BackgroundWe compared amino acid leakage among high-volume pre-dilution on-line hemodiafiltration (Pre O-HDF), hemodialysis (HD), and post-dilution...
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Depression promotes breast cancer progression by regulating amino acid neurotransmitter metabolism and gut microbial disturbance
IntroductionBreast cancer (BC) is the most prevalent type of cancer and has the highest mortality among women worldwide. BC patients have a high risk...
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Maternal glycemic status during pregnancy and mid-childhood plasma amino acid profiles: findings from a multi-ethnic Asian birth cohort
BackgroundIncreasing maternal glycaemia across the continuum during pregnancy may predispose offspring to subsequent cardiometabolic risk later in...
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Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts
BackgroundAmino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids...
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Effect of an enteral amino acid blend on muscle and gut functionality in critically ill patients: a proof-of-concept randomized controlled trial
BackgroundA defining feature of prolonged critical illness is muscle wasting, leading to impaired recovery. Supplementation with a tailored blend of...
