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Metformin in the Prevention of Alzheimer’s Disease and Alzheimer’s Disease Related Dementias
Metformin is a safe and effective medication for Type 2 diabetes (T2D) that has been proposed to decrease the risk of aging related disorders...
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Periodontal Disease and Alzheimer’s: Insights from a Systematic Literature Network Analysis
This study investigated the relationship between periodontal disease (PD) and Alzheimer’s Disease (AD) through a Systematic Literature Network...
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Progress on early diagnosing Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects both cognition and non-cognition functions. The disease follows a...
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China Alzheimer’s Disease and Neurodegenerative Disorder Research (CANDOR) -A Prospective Cohort Study for Alzheimer’s Disease and Vascular Cognitive Impairment
BackgroundAlzheimer’s disease (AD) and vascular cognitive impairment (VCI) are the two main causes of dementia. AD and VCI share similar symptoms of...
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Childhood obesity and risk of Alzheimer’s disease: a Mendelian randomization study
BackgroundMidlife obesity is a modifiable risk factor for Alzheimer’s disease. However, the association between childhood obesity and Alzheimer’s...
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Novel Blood-Based Biomarkers and Disease Modifying Therapies for Alzheimer’s Disease. Are We Ready for the New Era?
Recent positive trials for novel disease modifying therapies of anti-amyloid monoclonal antibodies represent a paradigm shift in the prevention and...
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Mendelian Randomization Analysis Reveals Causal Factors behind Alzheimer’s Disease Risk: Evidence, Opportunities, and Challenges
Alzheimer’s disease and its comorbidities pose a heavy disease burden globally, and its treatment remains a major challenge. Identifying the...
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Clinical importance in Alzheimer’s disease: effects of anchor agreement and disease severity
ObjectivesMethods of evaluating clinically meaningful decline are critical in research on Alzheimer’s disease. A common method of quantifying...
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Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank
BackgroundIdentifying prediagnostic neurodegenerative disease is a critical issue in neurodegenerative disease research, and Alzheimer’s disease (AD)...
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Alzheimer’s Disease: Novel Targets and Investigational Drugs for Disease Modification
Novel agents addressing non-amyloid, non-tau targets in Alzheimer’s Disease (AD) comprise 70% of the AD drug development pipeline of agents currently...
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Potential Implications of Slowing Disease Progression in Amyloid-Positive Early Alzheimer’s Disease: Estimates from Real-World Data
BackgroundEmerging therapies have shown promising results for slowing the progression of Alzheimer’s disease (AD). However, the potential impact of...
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Clinical Correlates of the PET-based Braak Staging Framework in Alzheimer’s Disease
In vivo Alzheimer’s disease diagnosis and staging is traditionally based on clinical features. However, the agreement between clinical and...
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Association of Circulating Caprylic Acid with Risk of Mild Cognitive Impairment and Alzheimer’s Disease in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Cohort
ObjectiveMedium-chain fatty acids (MCFAs) can rapidly cross the blood-brain barrier and provide an alternative energy source for the brain. This...
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Anti-amyloid Antibody Therapies for Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common cause of dementia, which is characterized by a progressive neurodegenerative disorder that is extremely...
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The role of glial autophagy in Alzheimer’s disease
Although Alzheimer’s disease is the most pervasive neurodegenerative disorder, the mechanism underlying its development is still not precisely...
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Cohort Effects in Alzheimer’s Disease Trials: An Empirical Assessment Utilizing Data from the Alzheimer’s Disease Cooperative Study
BackgroundCohort effects in study populations can impact clinical trial conclusions and generalizability, particularly in trials with planned interim...
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Anti-Amyloid Therapies for Alzheimer’s Disease: An Alzheimer Europe Position Paper and Call to Action
The growing prevalence and burden of Alzheimer’s disease has catalysed huge investments in research on its causes, diagnosis, treatment and care....
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Association of Vascular Endothelial Growth Factor Levels with Risk of Alzheimer’s Disease: A Systematic Review and Meta-Analysis
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative illness that leads to impairment of cognitive functions and memory loss. Even...
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Fruit Intake and Alzheimer’s Disease: Results from Mendelian Randomization
Alzheimer’s disease (AD) is the leading cause of dementia in old age, recognized as a global health priority. To explore causal effects of fresh...
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Causal influences of neuropsychiatric disorders on Alzheimer’s disease
Previous studies have observed a significant comorbidity between Alzheimer’s disease (AD) and some other neuropsychiatric disorders. However, the...
