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Metformin in the Prevention of Alzheimer’s Disease and Alzheimer’s Disease Related Dementias
Metformin is a safe and effective medication for Type 2 diabetes (T2D) that has been proposed to decrease the risk of aging related disorders...
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Periodontal Disease and Alzheimer’s: Insights from a Systematic Literature Network Analysis
This study investigated the relationship between periodontal disease (PD) and Alzheimer’s Disease (AD) through a Systematic Literature Network...
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Childhood obesity and risk of Alzheimer’s disease: a Mendelian randomization study
BackgroundMidlife obesity is a modifiable risk factor for Alzheimer’s disease. However, the association between childhood obesity and Alzheimer’s...
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China Alzheimer’s Disease and Neurodegenerative Disorder Research (CANDOR) -A Prospective Cohort Study for Alzheimer’s Disease and Vascular Cognitive Impairment
BackgroundAlzheimer’s disease (AD) and vascular cognitive impairment (VCI) are the two main causes of dementia. AD and VCI share similar symptoms of...
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Corneal innervation changes ın Alzheimer’s: implications for sensory dysfunction
PurposeTo compare, between Alzheimer’s disease (AD) patients and healthy individuals, corneal subbasal nerve plexus (CSNP) parameters and corneal...
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Progress on early diagnosing Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects both cognition and non-cognition functions. The disease follows a...
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Mendelian Randomization Analysis Reveals Causal Factors behind Alzheimer’s Disease Risk: Evidence, Opportunities, and Challenges
Alzheimer’s disease and its comorbidities pose a heavy disease burden globally, and its treatment remains a major challenge. Identifying the...
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Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank
BackgroundIdentifying prediagnostic neurodegenerative disease is a critical issue in neurodegenerative disease research, and Alzheimer’s disease (AD)...
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Association of Vascular Endothelial Growth Factor Levels with Risk of Alzheimer’s Disease: A Systematic Review and Meta-Analysis
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative illness that leads to impairment of cognitive functions and memory loss. Even...
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Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer’s disease (AD), and its accumulation has been considered as the...
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Clinical Correlates of the PET-based Braak Staging Framework in Alzheimer’s Disease
In vivo Alzheimer’s disease diagnosis and staging is traditionally based on clinical features. However, the agreement between clinical and...
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Anti-Amyloid Therapies for Alzheimer’s Disease: An Alzheimer Europe Position Paper and Call to Action
The growing prevalence and burden of Alzheimer’s disease has catalysed huge investments in research on its causes, diagnosis, treatment and care....
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Association of Circulating Caprylic Acid with Risk of Mild Cognitive Impairment and Alzheimer’s Disease in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Cohort
ObjectiveMedium-chain fatty acids (MCFAs) can rapidly cross the blood-brain barrier and provide an alternative energy source for the brain. This...
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Fruit Intake and Alzheimer’s Disease: Results from Mendelian Randomization
Alzheimer’s disease (AD) is the leading cause of dementia in old age, recognized as a global health priority. To explore causal effects of fresh...
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Cohort Effects in Alzheimer’s Disease Trials: An Empirical Assessment Utilizing Data from the Alzheimer’s Disease Cooperative Study
BackgroundCohort effects in study populations can impact clinical trial conclusions and generalizability, particularly in trials with planned interim...
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Anti-amyloid Antibody Therapies for Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common cause of dementia, which is characterized by a progressive neurodegenerative disorder that is extremely...
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Postoperative Pain Management in Alzheimer’s Disease—a Review
Purpose of ReviewIndividuals with dementia and Alzheimer’s disease (AD) often receive inadequate analgesia compared to those without cognitive...
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Association between Longitudinal Cerebrospinal Fluid Alzheimer’s Biomarkers and the Lifestyle for Brain Health (LIBRA) Index: Findings from the European Prevention of Alzheimer’s Dementia Cohort Study (EPAD LCS)
BackgroundIn the absence of preventative pharmacological interventions for Alzheimer’s Disease dementia, there is a growing interest in modifiable...
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The role of glial autophagy in Alzheimer’s disease
Although Alzheimer’s disease is the most pervasive neurodegenerative disorder, the mechanism underlying its development is still not precisely...
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The influence of growth and sex hormones on risk of alzheimer’s disease: a mendelian randomization study
Alzheimer’s disease is more prevalent in women, possibly due to sex or growth hormones but existing evidence is inconclusive. We investigated whether...
