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Advances in basic research on glucagon and alpha cells
The regulation of plasma amino acid levels by glucagon in humans first attracted the attention of researchers in the 1980s. Recent basic research...
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FAP expression in alpha cells of Langherhans insulae—implications for FAPI radiopharmaceuticals’ use
PurposeRadiopharmaceuticals targeting fibroblast activation protein (FAP) alpha are increasingly studied for diagnostic and therapeutic applications....
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In situ stoichiometry amounts of p62 and poly-ubiquitin exceed the increase of alpha-synuclein during degeneration of catecholamine cells induced by autophagy inhibition in vitro
Neurodegenerative disorders are typically featured by the occurrence of neuronal inclusions. In the case of Parkinson’s disease (PD) these correspond...
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Sex-dependent intra-islet structural rearrangements affecting alpha-to-beta cell interactions lead to adaptive enhancements of Ca2+ dynamics in prediabetic beta cells
Aims/hypothesisPrediabetic pancreatic beta cells can adapt their function to maintain normoglycaemia for a limited period of time, after which...
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Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
Aims/hypothesisType 2 diabetes is characterised by hyperglucagonaemia and perturbed function of pancreatic glucagon-secreting alpha cells but the...
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Incorporating IL7 receptor alpha signaling in the endodomain of B7H3-targeting chimeric antigen receptor T cells mediates antitumor activity in glioblastoma
CAR-T-cell therapy has shown promise in treating hematological malignancies but faces challenges in treating solid tumors due to impaired T-cell...
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Estrogen-related receptor alpha (ERRα) promotes the migration, invasion and angiogenesis of breast cancer stem cell-like cells
Breast cancer progression, metastasis and recurrence are largely driven by breast cancer stem cells (BCSCs), which constitute a subset of tumor cells...
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Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation
Aims/hypothesisGlucagon-expressing pancreatic alpha cells have attracted much attention for their plasticity to transdifferentiate into...
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Karyopherin Subunit Alpha 1 Enhances the Malignant Behaviors of Colon Cancer Cells via Promoting Nuclear Factor-κB p65 Nuclear Translocation
Background/AimsAberrant nuclear factor-κB p65 (NF-κB p65) nuclear import commonly occurs in multiple cancers, including colon cancer. According to...
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Alpha-lipoic acid induced apoptosis of PC3 prostate cancer cells through an alteration on mitochondrial membrane depolarization and MMP-9 mRNA expression
Cancer has become an important cause of mortality and morbidity in the world. Over the past decades, biomedical research revealed insights into the...
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Acquired thyroid-stimulating hormone, luteinizing hormone, and follicle-stimulating hormone deficiencies with circulating anti-glycoprotein hormones alpha chain-positive cell antibodies
BackgroundA patient with systemic lupus erythematosus (SLE) suffered from acquired thyroid-stimulating hormone (TSH), luteinizing hormone (LH), and...
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Combined light and electron microscopy (CLEM) to quantify methamphetamine-induced alpha-synuclein-related pathology
Methamphetamine (METH) produces a cytopathology, which is rather specific within catecholamine neurons both in vitro and ex vivo, in animal models...
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Serum alpha 1 antitrypsin potent act as an early diagnostic biomarker for cardiac amyloidosis
Cardiac amyloidosis is a refractory cardiomyopathy with a poor prognosis and lacks effective treatments. N-terminal pro-brain natriuretic peptide...
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Food Allergies and Alpha-gal Syndrome for the Gastroenterologist
Purpose of ReviewFood allergies are typically not considered as a cause of gastrointestinal (GI) distress without additional allergic symptoms, apart...
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Occurrence of Monoclonal Band in Alpha Region on Serum Electrophoresis in Multiple Myeloma: A Diagnostic Conundrum
The presence of an M-band in serum and/or urine electrophoresis is a crucial diagnostic indicator for multiple myeloma and other plasma cell...
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Targeted Alpha Therapy for Glioblastoma: Review on In Vitro, In Vivo and Clinical Trials
Glioblastoma (GB), a prevalent and highly malignant primary brain tumour with a very high mortality rate due to its resistance to conventional...
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Association between osteocalcin, a pivotal marker of bone metabolism, and secretory function of islet beta cells and alpha cells in Chinese patients with type 2 diabetes mellitus: an observational study
BackgroundSeveral recent studies have found that Osteocalcin (OCN), a multifunctional protein secreted exclusively by osteoblasts, is beneficial to...
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Can current preclinical strategies for radiopharmaceutical development meet the needs of targeted alpha therapy?
Preclinical studies are essential for effectively evaluating TAT radiopharmaceuticals. Given the current suboptimal supply chain of these...
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Alpha-fetoprotein producing endometrioid carcinoma arising in an adenomyoma of the uterus
We report a case of alpha-fetoprotein-producing endometrioid carcinoma (AFP-EC) that originated within an adenomyoma of the uterine corpus. A...
