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Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation
BackgroundCardiovascular diseases, including diabetic cardiomyopathy, are major causes of death in people with type 2 diabetes. Aldose reductase...
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Comparative Evaluation of Aldose Reductase Inhibition in Polycystic Ovarian Syndrome–Induced Rats
Polycystic ovary syndrome (PCOS) represents a spectrum of disorders, associated with hyperandrogenism, oligoanovulation, and polycystic ovaries....
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Syzygium aromaticum bud (clove) essential oil is a novel and safe aldose reductase inhibitor: in silico, in vitro, and in vivo evidence
PurposeThis study aimed to evaluate the antioxidant and antidiabetic properties of clove essential oil (CEO) and to elucidate its mode of action,...
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Carica papaya Linn. fruit extract inhibited the activities of aldose reductase and sorbitol dehydrogenase: possible mechanism for amelioration of diabetic complications
BackgroundDiabetes mellitus is a metabolic disorder which is associated with debilitating complications including eye disease, kidney disorder, and...
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Cheminformatics identification of modulators of key carbohydrate-metabolizing enzymes from C. cujete for type-2 diabetes mellitus intervention
PurposeThe therapeutic use of oral hypoglycaemic agents in the management of type-2 diabetes mellitus (T2DM) is without adverse effects; thus, calls...
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Two rare flavonoid glycosides from Litsea glutinosa (Lour.) C. B. Rob.: experimental and computational approaches endorse antidiabetic potentiality
BackgroundLitsea glutinosa (Lour.) C. B. Rob. belongs to the Litsea genus and is categorized under the family of Lauraceae . The study aimed to...
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Characterizing diabetic cardiomyopathy: baseline results from the ARISE-HF trial
BackgroundDiabetic cardiomyopathy (DbCM) is a form of Stage B heart failure (HF) at high risk for progression to overt disease. Using baseline...
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Highlights of Cardiovascular Disease Prevention Studies Presented at the 2024 American College of Cardiology Conference
Purpose of ReviewTo summarize selected late-breaking science on cardiovascular (CV) disease prevention presented at the 2024 Scientific Session of...
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Is there any robust evidence showing that SGLT2 inhibitor use predisposes to acute kidney injury?
A novel class of oral glucose lowering drugs, sodium-glucose co-transporter type 2 inhibitors (SGLT2is), has shown additional beneficial effects on...
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Diabetic vascular diseases: molecular mechanisms and therapeutic strategies
Vascular complications of diabetes pose a severe threat to human health. Prevention and treatment protocols based on a single vascular complication...
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Evaluating treatment options for cardiovascular autonomic neuropathy in patients with diabetes mellitus: a systematic review
BackgroundCardiovascular autonomic neuropathy (CAN) is a debilitating complication of diabetes mellitus. To date, there is no systematic review on...
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Plant bioactive compounds and their mechanistic approaches in the treatment of diabetes: a review
BackgroundDiabetes mellitus (DM) is a growing disease across the world; diabetes is a complex metabolic disorder in which blood glucose concentration...
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Epalrestat, an Aldose Reductase Inhibitor, Restores Erectile Function in Streptozocin-induced Diabetic Rats
Epalrestat, an aldose reductase inhibitor (ARI), was adopted to improve the function of peripheral nerves in diabetic patients. The aim of this study...
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Diabetic neuropathy: an insight on the transition from synthetic drugs to herbal therapies
The global pandemic of prediabetes and diabetes has led to a severe corresponding complication of these disorders. Neuropathy is one of the most...
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Congenital disorders of glycosylation: narration of a story through its patents
Congenital disorders of glycosylation are a group of more than 160 rare genetic defects in protein and lipid glycosylation. Since the first clinical...
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Fructose might be a clue to the origin of preeclampsia insights from nature and evolution
Preeclampsia is a hypertensive disorder of pregnancy and is due to abnormal placentation. The pathogenesis remains unclear. Fructose is biologically...
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Prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy in Japanese patients with type 2 diabetes: the Japan Diabetes Complication and its Prevention Prospective study (JDCP study 10)
Aim/introductionThis study aims to investigate the prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy (DSPN) in...
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Potential role of oxidative stress in the pathogenesis of diabetic bladder dysfunction
Diabetes mellitus is a chronic metabolic disease, posing a considerable threat to global public health. Treating systemic comorbidities has been one...
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Correction: Epalrestat, an Aldose Reductase Inhibitor, Restores Erectile Function in Streptozocin-induced Diabetic Rats
This Article was originally published under Nature Research’s License to Publish, but has now been made available under a CC BY 4.0 license. The PDF...
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Flubendazole carbonyl reduction in drug-susceptible and drug-resistant strains of the parasitic nematode Haemonchus contortus: changes during the life cycle and possible inhibition
Carbonyl-reducing enzymes (CREs) catalyse the reduction of carbonyl groups in many eobiotic and xenobiotic compounds in all organisms, including...
