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Replacing the Clinical Institute Withdrawal Assessment—Alcohol revised with the modified Richmond Agitation and Sedation Scale for alcohol withdrawal to support management of alcohol withdrawal symptoms: potential impact on length of stay and complications
PurposeWe evaluated impact on length of stay and possible complications of replacing the Clinical Institute Withdrawal Assessment—Alcohol Revised...
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LPA1 receptors in the lateral habenula regulate negative affective states associated with alcohol withdrawal
The role of lysophosphatidic acid (LPA) signaling in psychiatric disorders and drug abuse is significant. LPA receptors are widely expressed in the...
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An innovative inpatient protocol for alcohol withdrawal prevention in a 16-year-old adolescent: a case report
BackgroundAlcohol cessation in youth with daily drinking poses a risk of severe and life-threatening alcohol withdrawal. If unsupervised, alcohol...
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Risk factors associated with 1-week revisit among emergency department patients with alcohol withdrawal
BackgroundApproximately one-quarter of emergency department (ED) visits for alcohol withdrawal result in unscheduled 1-week ED return visits, but it...
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Naturalistic comparison of clomethiazole and Diazepam treatment in alcohol withdrawal: effects on oxidative stress, inflammatory cytokines and hepatic biomarkers
Ethanol is metabolized by alcohol dehydrogenase to acetaldehyde and induces cytochrome P450 2E1 (CYP2E1), which generates reactive oxygen species...
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ANK3 rs10994336 and ZNF804A rs7597593 polymorphisms: genetic interaction for emotional and behavioral symptoms of alcohol withdrawal syndrome
ObjectiveAlcohol withdrawal syndrome (AWS) is a complex condition associated with alcohol use disorder (AUD), characterized by significant variations...
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Prevention of alcohol withdrawal seizure recurrence and treatment of other alcohol withdrawal symptoms in the emergency department: a rapid review
BackgroundPatients who experience harms from alcohol and other substance use often seek care in the emergency department (ED). ED visits related to...
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Cell-type specific changes in PKC-delta neurons of the central amygdala during alcohol withdrawal
The central amygdala (CeA) contains a diverse population of cells, including multiple subtypes of GABAergic neurons, along with glia and epithelial...
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Alcohol Use: Assessment, Withdrawal Management, Treatment and Therapy Ethical Practice
The book brings together the most up-to-date knowledge and expertise covering the whole topic of alcohol. It presents the practical skills needed to...
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Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report
BackgroundEthanol dependence is associated with a discontinuation withdrawal delirium. Chlordiazepoxide is frequently successfully used in its...
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Severe diaphoresis and fever during alcohol withdrawal cause hypovolemic shock: case report
BackgroundSeveral fatal medical complications have been associated with alcohol withdrawal, such as seizure, cardiac arrhythmia, and takotsubo...
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Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism
Neurofilament light chain (NFL), as a measure of neuroaxonal injury, has recently gained attention in alcohol dependence (AD). Aldehyde dehydrogenase...
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Pharmacological Treatment of GHB Withdrawal Syndrome
Purpose of ReviewGamma-hydroxybutyrate (GHB) is an illicit drug used for many reasons: during music festivals or parties, for self-management of...
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Chronic MAP4343 reverses escalated alcohol drinking in a mouse model of alcohol use disorder
Alcohol use disorders can be driven by negative reinforcement. Alterations of the microtubule cytoskeleton have been associated with mood regulation...
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Phenobarbital for the management of severe acute alcohol withdrawal (the PHENOMANAL trial): a pilot randomized controlled trial
BackgroundBenzodiazepines are considered first-line treatment for patients experiencing severe acute alcohol withdrawal syndrome (sAAWS). Although...
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Motives for alcohol use, risky drinking patterns and harm reduction practices among people who experience homelessness and alcohol dependence in Montreal
BackgroundPeople experiencing homelessness are disproportionately affected by harms related to alcohol use. Indeed, their alcohol dependence is...
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Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure
Alcohol use disorder (AUD) is highly comorbid with depression. Withdrawal from chronic alcohol drinking results in depression and understanding brain...
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Withdrawal during outpatient low dose buprenorphine initiation in people who use fentanyl: a retrospective cohort study
BackgroundBuprenorphine is an effective treatment for opioid use disorder (OUD); however, buprenorphine initiation can be complicated by withdrawal...
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Protective effect of methanolic extract of Areca catechu nut on ethanol withdrawal symptoms in mice
BackgroundThe purpose of the current study was to examine the potential impact of a methanolic extract of Areca catechu nut (MAN) on...
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Genetic and genomic signatures in ethanol withdrawal seizure-prone and seizure-resistant mice implicate genes involved in epilepsy and neuronal excitability
Alcohol withdrawal is a clinically important consequence and potential driver of Alcohol Use Disorder. However, susceptibility to withdrawal...
