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Small airways morphological alterations associated with functional impairment in lymphangioleiomyomatosis
BackgroundLymphangioleiomyomatosis (LAM) is a rare neoplastic and cystic pulmonary disease characterized by abnormal proliferation of the so-called...
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Impact of Biologic Therapy on the Small Airways Asthma Phenotype
The small airways dysfunction (SAD) asthma phenotype is characterised by narrowing of airways < 2 mm in diameter between generations 8 and 23 of the...
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Dysregulation of iron homeostasis in airways associated with persistent preschool wheezing
BackgroundCurrently, there are no reliable clinical tools available to identify persistent asthma symptoms among preschool children with recurrent...
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Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways
IntroductionThe standard therapy for bronchial asthma consists of combinations of acute (short-acting ß 2 -sympathomimetics) and, depending on the...
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Morphologically intact airways in lung fibrosis have an abnormal proteome
Honeycombing is a histological pattern consistent with Usual Interstitial Pneumonia (UIP). Honeycombing refers to cystic airways located at sites of...
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Mucus plugs in the airways of asthmatic subjects and smoking status
BackgroundMucus plugs have been described in the airways of asthmatic subjects, particularly those with associated with type 2 inflammation and...
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Modeled small airways lung deposition of two fixed-dose triple therapy combinations assessed with in silico functional respiratory imaging
BackgroundSmall airways disease plays a key role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and is a major cause of...
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Local heterogeneity of normal lung parenchyma and small airways disease are associated with COPD severity and progression
BackgroundSmall airways disease (SAD) is a major cause of airflow obstruction in COPD patients and has been identified as a precursor to emphysema....
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Airways and craniofacial assessment in children affected by achondroplasia with and without sleep-disordered breathing: quantitative magnetic resonance study
PurposeTo identify MRI-based quantitative craniofacial variables linked to airways narrowing and obstructive sleep apnea (OSA) development in...
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Releasing high positive end-expiratory pressure to a low level generates a pronounced increase in particle flow from the airways
ObjectivesDetecting particle flow from the airways by a non-invasive analyzing technique might serve as an additional tool to monitor mechanical...
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Effects of tissue degradation by collagenase and elastase on the biaxial mechanics of porcine airways
BackgroundCommon respiratory illnesses, such as emphysema and chronic obstructive pulmonary disease, are characterized by connective tissue damage...
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Chronic Airways Assessment Test: psychometric properties in patients with asthma and/or COPD
BackgroundNo short patient-reported outcome (PRO) instruments assess overall health status across different obstructive lung diseases. Thus, the...
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Monoclonal antibodies targeting small airways: a new perspective for biological therapies in severe asthma
Small airway dysfunction (SAD) in asthma is characterized by the inflammation and narrowing of airways with less of 2 mm in diameter between...
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Effects of cleaning spray use on eyes, airways, and ergonomic load
BackgroundCleaning workers are exposed to chemicals and high physical workload, commonly resulting in airway problems and pain. In this study the...
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Comparison of video laryngoscope, video stylet, and flexible videoscope for transoral endotracheal intubation in patients with difficult airways: a randomized, parallel-group study
BackgroundThe 2022 ASA guidelines recommend the video laryngoscope, video stylet, and flexible videoscope as airway management tools. This study aims...
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CT findings of non-neoplastic central airways diseases
Non-neoplastic lesions of central airways are uncommon entities with different etiologies, with either focal or diffuse involvement of the...
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Canadian multidisciplinary expert consensus on the use of biologics in upper airways: a Delphi study
BackgroundChronic rhinosinusitis with nasal polyposis (CRSwNP) often coexists with lower airway disease. With the overlap between upper and lower...
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The association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life: results from the Burden of Obstructive Lung Disease (BOLD) study
BackgroundSpirometric small airways obstruction (SAO) is common in the general population. Whether spirometric SAO is associated with respiratory...
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Creating a training set for artificial intelligence from initial segmentations of airways
Airways segmentation is important for research about pulmonary disease but require a large amount of time by trained specialists. We used an openly...
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Associations between long-term ozone exposure and small airways function in Chinese young adults: a longitudinal cohort study
BackgroundIncreasing evidence is appearing that ozone has adverse effects on health. However, the association between long-term ozone exposure and...
