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CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity
BackgroundThe primary underlying defect in cystic fibrosis (CF) is disrupted ion transport in epithelia throughout the body. It is unclear if...
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Vascular endothelial growth factor induces the migration of human airway smooth muscle cells by activating the RhoA/ROCK pathway
BackgroundAirway remodeling due to increased airway smooth muscle cell (ASMC) mass, likely due to enhanced proliferation, hypertrophy, and migration,...
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Long non-coding RNA MEG3 knockdown represses airway smooth muscle cells proliferation and migration via sponging miR-143-3p/FGF9 in asthma
BackgroundAsthma is a respiratory disease characterized by airway remodeling. We aimed to find out the role and mechanism of lncRNA MEG3 in asthma.
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Critical roles of airway smooth muscle in mediating deep-inspiration-induced bronchodilation: a big stretch?
BackgroundDeep inspiration (DI) has been shown to induce bronchodilation and bronchoprotection in bronchochallenged healthy subjects, but not in...
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Expression of glucocorticoid receptor and HDACs in airway smooth muscle cells is associated with response to steroids in COPD
BackgroundSteroid insensitivity in Chronic Obstructive Pulmonary Disease (COPD) presents a problem for controlling the chronic inflammation of the...
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Inhibitory Effect of S100A11 on Airway Smooth Muscle Contraction and Airway Hyperresponsiveness
ObjectiveS100A11 is a member of the S100 calcium-binding protein family and has intracellular and extracellular regulatory activities. We previously...
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Crosstalk between diacylglycerol kinase and protein kinase A in the regulation of airway smooth muscle cell proliferation
BackgroundDiacylglycerol kinase (DGK) regulates intracellular signaling and functions by converting diacylglycerol (DAG) into phosphatidic acid. We...
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Anti-asthmatic miR-224-5p inhibits the FHL1/MAPK pathway to repress airway smooth muscle cell proliferation in a murine model of asthma-like airway inflammation
BackgroundThe proliferation of airway smooth muscle cells (ASMCs) contributes to the contractility and inflammation in the pathophysiology of asthma....
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Role of airway smooth muscle cell phenotypes in airway tone and obstruction in guinea pig asthma model
BackgroundAirway obstruction (AO) in asthma is driven by airway smooth muscle (ASM) contraction. AO can be induced extrinsically by direct...
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CEBPD modulates the airway smooth muscle transcriptomic response to glucocorticoids
BackgroundCCAAT/Enhancer Binding Protein D (CEBPD), a pleiotropic glucocorticoid-responsive transcription factor, modulates inflammatory responses....
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The intermediate filament protein nestin serves as a molecular hub for smooth muscle cytoskeletal signaling
BackgroundThe recruitment of the actin-regulatory proteins cortactin and profilin-1 (Pfn-1) to the membrane is important for the regulation of actin...
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Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle
BackgroundCorticosteroids remain a key therapy for treating children with asthma. Patients with severe asthma are insensitive, resistant, or...
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TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway
BackgroundChildhood asthma is a common respiratory disease characterized by airway inflammation. Tumor necrosis factor-α-induced protein 8-like 2...
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Angiotensin-(1–7) suppresses airway inflammation and airway remodeling via inhibiting ATG5 in allergic asthma
BackgroundAngiotensin (Ang)-(1–7) can reduce airway inflammation and airway remodeling in allergic asthma. Autophagy-related 5 (ATG5) has attracted...
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Rhinovirus induces airway remodeling: what are the physiological consequences?
BackgroundRhinovirus infections commonly evoke asthma exacerbations in children and adults. Recurrent asthma exacerbations are associated with...
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Inhibitory Effect of PPARδ Agonist GW501516 on Proliferation of Hypoxia-induced Pulmonary Arterial Smooth Muscle Cells by Regulating the mTOR Pathway
ObjectiveThis study aimed to investigate the effects of the peroxisome proliferator-activated receptor δ (PPARδ) agonist GW501516 on the...
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The airway neuro-immune axis as a therapeutic target in allergic airway diseases
Recent evidence has increasingly underscored the importance of the neuro-immune axis in mediating allergic airway diseases, such as allergic asthma...
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Heat-Induced Secretion of Heat Shock Proteins 70 and 90 Does not Affect the Expression of the Glucocorticoid Receptor in Primary Airway Cells in COPD
PurposeThe response to glucocorticoids is hampered in many COPD patients by a yet unknown mechanism. Earlier we reported that short-term heat...
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Rhinovirus infection induces secretion of endothelin-1 from airway epithelial cells in both in vitro and in vivo models
BackgroundRhinovirus (RV) infection of airway epithelial cells triggers asthma exacerbations, during which airway smooth muscle (ASM) excessively...
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Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma
Obesity-related asthma is associated with a high disease burden and a poor response to existent asthma therapies, suggesting that it is a distinct...
