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Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease
BackgroundAsthma patients with comorbid obesity exhibit increased disease severity, in part, due to airway remodeling, which is also observed in...
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Relationship between airway inflammation, small airway dysfunction, and frequency of acute exacerbations in patients with chronic obstructive pulmonary disease
ContextRecurrent exacerbations in COPD patients are associated with accelerated reduction in lung function. Airway inflammation and small airway...
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Advances in Airway Stenting
Purpose of ReviewIn this review, we summarize the evolution of airway stents through the decades and address the various existing stent types along...
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Imaging features and clinical value of 18F-FDG PET/CT for predicting airway involvement in patients with relapsing polychondritis
BackgroundThe clinical value of 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in assessing relapsing...
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Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease
BackgroundAirway remodeling is a significant contributor to impaired lung function in chronic allergic airway disease. Currently, no therapy exists...
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Rhinovirus induces airway remodeling: what are the physiological consequences?
BackgroundRhinovirus infections commonly evoke asthma exacerbations in children and adults. Recurrent asthma exacerbations are associated with...
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VEGF and EGFR signaling pathways are involved in the baicalein attenuation of OVA-induced airway inflammation and airway remodeling in mice
BackgroundAlthough Traditional Chinese Medicine (TCM) has been used for treating asthma for centuries, the understanding of its mechanism of action...
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Astaxanthin attenuates cigarette smoke-induced small airway remodeling via the AKT1 signaling pathway
BackgroundAstaxanthin (AXT) is a keto-carotenoid with a variety of biological functions, including antioxidant and antifibrotic effects. Small airway...
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Human airway tuft cells influence the mucociliary clearance through cholinergic signalling
BackgroundAirway tuft cells, formerly called brush cells have long been described only morphologically in human airways. More recent RNAseq studies...
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In vitro platform to model the function of ionocytes in the human airway epithelium
BackgroundPulmonary ionocytes have been identified in the airway epithelium as a small population of ion transporting cells expressing high levels of
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Airway disease decreases the therapeutic potential of epithelial stem cells
BackgorundTissue-engineered tracheal grafts (TETG) can be recellularized by the host or pre-seeded with host-derived cells. However, the impact of...
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A review of the current status and progress in difficult airway assessment research
A difficult airway is a situation in which an anesthesiologist with more than 5 years of experience encounters difficulty with intubation or mask...
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Targeting lysyl oxidase like 2 attenuates OVA-induced airway remodeling partly via the AKT signaling pathway
BackgroundAirway epithelium is an important component of airway structure and the initiator of airway remodeling in asthma. The changes of...
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Quercetin improves epithelial regeneration from airway basal cells of COPD patients
BackgroundAirway basal cells (BC) from patients with chronic obstructive pulmonary disease (COPD) regenerate abnormal airway epithelium and this was...
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Radiographic airway abnormalities in untreated early rheumatoid arthritis are associated with peripheral neutrophil activation
BackgroundThe role of the lung for the initiation and progression of rheumatoid arthritis (RA) is still unclear. Up to 10% of RA patients develop...
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Statin administration or blocking PCSK9 alleviates airway hyperresponsiveness and lung fibrosis in high-fat diet-induced obese mice
BackgroundObesity is associated with airway hyperresponsiveness and lung fibrosis, which may reduce the effectiveness of standard asthma treatment in...
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Single-cell analysis reveals alterations in cellular composition and cell-cell communication associated with airway inflammation and remodeling in asthma
BackgroundAsthma is a heterogeneous disease characterized by airway inflammation and remodeling, whose pathogenetic complexity was associated with...
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The association of upper airway anatomy with cognitive test performance: the Multi-Ethnic Study of Atherosclerosis
BackgroundNumerous upper airway anatomy characteristics are risk factors for sleep apnea, which affects 26% of older Americans, and more severe sleep...
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Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease
Little is known about the relationships between human genetics and the airway microbiome. Deeply sequenced airway metagenomics, by simultaneously...
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Particulate matter10-induced airway inflammation and fibrosis can be regulated by chitinase-1 suppression
BackgroundParticulate matter 10 (PM 10 ) can induce airway inflammation and fibrosis. Recently, chitinase-1 has been shown to play key roles in...
