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The integrin receptor beta7 subunit mediates airway remodeling and hyperresponsiveness in allergen exposed mice
BackgroundFibroblast differentiation to a myofibroblast phenotype is a feature of airway remodeling in asthma. Lung fibroblasts express the integrin...
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Chronic intermittent hypoxia increases airway hyperresponsiveness during house dust mites exposures in rats
IntroductionAccumulating clinical evidence links Obstructive Sleep Apnea (OSA) with worse outcomes of asthma, but impact on airway function remains...
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Statin administration or blocking PCSK9 alleviates airway hyperresponsiveness and lung fibrosis in high-fat diet-induced obese mice
BackgroundObesity is associated with airway hyperresponsiveness and lung fibrosis, which may reduce the effectiveness of standard asthma treatment in...
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Inhibitory Effect of S100A11 on Airway Smooth Muscle Contraction and Airway Hyperresponsiveness
ObjectiveS100A11 is a member of the S100 calcium-binding protein family and has intracellular and extracellular regulatory activities. We previously...
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Targeting of G-protein coupled receptor 40 alleviates airway hyperresponsiveness through RhoA/ROCK1 signaling pathway in obese asthmatic mice
Obesity increases the severity of airway hyperresponsiveness (AHR) in individuals with asthma, but the mechanism is not well elucidated. G-protein...
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The role of small airway function parameters in preschool asthmatic children
BackgroundSmall airways are the major sites of inflammation and airway remodeling in all severities of asthma patients. However, whether small airway...
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A novel quinoline with airway relaxant effects and anti-inflammatory properties
BackgroundIn chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for...
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Rhinovirus infection induces secretion of endothelin-1 from airway epithelial cells in both in vitro and in vivo models
BackgroundRhinovirus (RV) infection of airway epithelial cells triggers asthma exacerbations, during which airway smooth muscle (ASM) excessively...
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Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2-p65 pathway
Exposure to particulate matter 2.5 (PM2.5) potentially triggers airway inflammation by activating nuclear factor-κB (NF-κB). Sirtuin 2 (SIRT2) is a...
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Airway and parenchyma transcriptomics in a house dust mite model of experimental asthma
Lung transcriptomics studies in asthma have provided valuable information in the whole lung context, however, deciphering the individual...
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Rhinovirus induces airway remodeling: what are the physiological consequences?
BackgroundRhinovirus infections commonly evoke asthma exacerbations in children and adults. Recurrent asthma exacerbations are associated with...
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CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity
BackgroundThe primary underlying defect in cystic fibrosis (CF) is disrupted ion transport in epithelia throughout the body. It is unclear if...
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Hyperresponsiveness to Extracellular Acidification-Mediated Contraction in Isolated Bronchial Smooth Muscles of Murine Experimental Asthma
PurposeExtracellular acidification is a major component of tissue inflammation, including airway inflammation. The extracellular proton-sensing...
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Neutrophil activation and NETosis are the predominant drivers of airway inflammation in an OVA/CFA/LPS induced murine model
BackgroundAsthma is one of the most common chronic diseases that affects more than 300 million people worldwide. Though most asthma can be well...
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Variants in transient receptor potential channels and toll-like receptors modify airway responses to allergen and air pollution: a randomized controlled response human exposure study
BackgroundEnvironmental co-exposure to allergen and traffic-related air pollution is common globally and contributes to the exacerbation of...
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Interleukin-22 attenuates allergic airway inflammation in ovalbumin-induced asthma mouse model
BackgroundAllergic asthma is a chronic airway inflammatory disease with a number of cytokines participating in its pathogenesis and progress....
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Angiotensin-(1–7) suppresses airway inflammation and airway remodeling via inhibiting ATG5 in allergic asthma
BackgroundAngiotensin (Ang)-(1–7) can reduce airway inflammation and airway remodeling in allergic asthma. Autophagy-related 5 (ATG5) has attracted...
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GITRL on dendritic cells aggravates house dust mite-induced airway inflammation and airway hyperresponsiveness by modulating CD4+ T cell differentiation
BackgroundGlucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) plays an important role in tumors, autoimmunity...
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Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation
BackgroundMacrophage migration inhibitory factor (MIF) and GTPase dynamin-related protein 1 (Drp1)-dependent aberrant mitochondrial fission are...
