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From premature birth to premature kidney disease: does accelerated aging play a role?
As the limits of fetal viability have increased over the past 30 years, there has been a growing body of evidence supporting the idea that chronic...
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Transcription factor NRF2 as potential therapeutic target for preventing muscle wasting in aging chronic kidney disease patients
Increased muscle protein catabolism leading to muscle wasting is a prominent feature of the syndrome of protein-energy wasting (PEW) in patients with...
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Consequences of kidney donation by age in Japanese living kidney donors: a single-center study
BackgroundElderly living kidney donors (LKDs) are becoming increasingly important in countries with a high prevalence of living-donor kidney...
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Treatment of chronic kidney disease in older populations
As the world population ages, an expected increase in the prevalence of chronic kidney disease (CKD) among older individuals will pose a considerable...
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Prevention of Chronic Kidney Disease and Its Complications in Older Adults
In an era marked by a global demographic shift towards an aging society, there is a heightened prevalence of chronic kidney disease (CKD) among older...
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Age-Related Changes and Loss of Damage Resistance of Kidney Tissue: The Role of a Decrease in the Number of Kidney Resident Progenitor Cells
AbstractMany organs undergo negative changes during aging that affect their functions and ability to regenerate. In particular, the kidneys become...
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Acute kidney injury and aging
Our aging population is growing and develo** treatments for age-related diseases such as Alzheimer’s and Parkinson’s disease has taken on an...
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Trends, Outcomes, and Evaluation of the Older Living Kidney Donor
Purpose of ReviewWe aim to review trends, donor and recipient outcomes, and considerations in the evaluation of older living kidney donors (LD).
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Epigenetic regulation of aging: implications for interventions of aging and diseases
Aging is accompanied by the decline of organismal functions and a series of prominent hallmarks, including genetic and epigenetic alterations. These...
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Impact of Immunosenescence in Older Kidney Transplant Recipients: Associated Clinical Outcomes and Possible Risk Stratification for Immunosuppression Reduction
The number of older individuals receiving a kidney transplant as replacement therapy has significantly increased in the past decades and this...
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Staying Healthy with Kidney Disease A Complete Guide for Patients
Patients with kidney disease often find it difficult to understand and undertake the lifestyle changes that will help them stay as healthy as...
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Effects of bisphosphonates and treadmill exercise on bone and kidney in adenine-induced chronic kidney disease rats
IntroductionThe increasing prevalence of osteoporosis and chronic kidney disease (CKD) due to the aging of society has highlighted the need for...
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Female germline stem cells: aging and anti-aging
The delay of ovarian aging and the fertility preservation of cancer patients are the eternal themes in the field of reproductive medicine. Acting as...
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Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and...
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Nanoparticles in the diagnosis and treatment of vascular aging and related diseases
Aging-induced alternations of vasculature structures, phenotypes, and functions are key in the occurrence and development of vascular aging-related...
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Testosterone deficiency and the aging male
Testosterone deficiency (TD), also known as male hypogonadism, is a complex syndrome encompassing physical, biochemical, and social aspects that...
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Ellagic acid ameliorates aging-induced renal oxidative damage through upregulating SIRT1 and NRF2
BackgroundAging is associated with impaired renal function and structural alterations. Oxidative stress plays a vital role in renal senescence and...
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Autopsy study examining non-chronic kidney disease versus chronic kidney disease caused by hypertensive-nephrosclerosis in elderly subjects
BackgroundThe aim of this autopsy study was to clarify the differences of renal histopathology between non-chronic kidney disease (CKD) and CKD...
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The Aryl Hydrocarbon Receptor, Epigenetics and the Aging Process
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, classically associated with the regulation of xenobiotic metabolism...