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Modern practical management of acute severe colitis
Acute severe ulcerative colitis (ASUC) is one of life-threatening complications that occur in one-fifth of ulcerative colitis (UC) patients with...
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Low prevalence of Clostridioides difficile infection in acute severe ulcerative colitis: A retrospective cohort study from northern India
BackgroundThe incidence of Clostridioides difficile infection (CDI) is high in ulcerative colitis and is associated with disease flares and adverse...
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Effectiveness of Tofacitinib for Hospitalized Patients with Acute Severe Ulcerative Colitis: Case Series
BackgroundTreatment options for acute severe ulcerative colitis (ASUC) are limited. Tofacitinib, an approved treatment for moderate to severe...
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Infliximab versus ciclosporin in steroid resistant acute severe ulcerative colitis: a model-based cost-utility analysis of data from CONSTRUCT pragmatic trial
BackgroundThere is limited evidence in the literature on the long-term effectiveness and cost-effectiveness of treatments for Acute Severe Ulcerative...
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Real-world efficacy and safety of advanced therapies in hospitalized patients with ulcerative colitis
BackgroundThis multicenter observational cohort study aimed to evaluate the utilization and short-term efficacy of advanced therapy (AT) in...
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Prospective validation of AIIMS index as a predictor of steroid failure in patients with acute severe ulcerative colitis
BackgroundOptimal outcomes in acute severe ulcerative colitis (ASUC) are related to time-bound management based upon early prediction of response to...
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Delayed Initiation of Rescue Therapy Associated with Increased Length of Stay in Acute Severe Ulcerative Colitis
BackgroundReducing hospitalization length of stay (LOS) for acute severe ulcerative colitis (ASUC) will reduce healthcare costs, mitigate...
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Emergency colectomy for acute severe ulcerative colitis: a nationwide survey on technical strategies of the Italian society of colorectal surgery (SICCR)
Emergency subtotal colectomy is the standard treatment for acute severe ulcerative colitis (ASUC) unresponsive to medical treatment. No guidelines...
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Medical treatment selection and outcomes for hospitalized patients with severe ulcerative colitis as defined by the Japanese criteria
BackgroundHospitalization for ulcerative colitis (UC) is potentially life-threatening. Severe disease in the Japanese criteria which modifies the...
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Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus
BackgroundIntravenous corticosteroid is the mainstay for managing acute severe ulcerative colitis, but one-third of patients do not respond to...
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Acute severe ulcerative colitis: management advice for internal medicine and emergency physicians
Acute severe ulcerative colitis is a medical emergency that warrants in-patient management. This is best served within a multidisciplinary team...
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Sarcopenia assessed by computed tomography is associated with colectomy in patients with acute severe ulcerative colitis
BackgroundAltered body composition is an important characteristic of malnutrition that may better reflect the clinical course. This study aimed to...
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Tofacitinib use in ulcerative colitis: An expert consensus for day-to-day clinical practice
Rising number of inflammatory bowel disease (IBD) cases in develo** countries necessitate clear guidance for clinicians for the appropriate use of...
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Serum Cytomegalovirus Polymerase Chain Reaction Test Is a Valuable Negative Predictor of Infection in Acute Severe Ulcerative Colitis
BackgroundDiagnosis of cytomegalovirus (CMV) colitis in the setting of severe ulcerative colitis (UC) remains a clinical challenge. This study aimed...
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Efficacy of upadacitinib in the achievement of clinical and endoscopic remission in hospitalized patients with ulcerative colitis
Janus kinase (JAK) inhibitors have been developed and are clinically available for management of active UC patients although most studies have been...
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Comparison of 1-Year Colectomy Risk Between the US and Korean Patients with Acute Severe Ulcerative Colitis: A Propensity Score Matching Analysis
BackgroundColectomy risk after acute severe ulcerative colitis (ASUC) has not been compared between Eastern and Western countries. We compared the...
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A Systematic Review of the Economic and Health-Related Quality of Life Impact of Advanced Therapies Used to Treat Moderate-to-Severe Ulcerative Colitis
IntroductionThe clinical benefits of advanced therapies (i.e., biologics and small-molecule drugs) in the treatment of moderate-to-severe ulcerative...
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