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Pediatric Acute-on-Chronic Liver Failure
Acute-on-chronic liver failure (ACLF) is characterized by an acute hepatic insult happening in a patient with underlying cirrhosis with compromised...
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Intensive care management of acute-on-chronic liver failure
Acute-on-chronic liver failure (ACLF) is a clinical syndrome defined by an acute deterioration of the liver function associated with extrahepatic...
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Acute-on-chronic liver failure: far to go—a review
Acute-on-chronic liver failure (ACLF) has been recognized as a severe clinical syndrome based on the acute deterioration of chronic liver disease and...
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Acute Kidney Injury in Acute on Chronic Liver Failure Versus Decompensated Cirrhosis—What Is the Difference?
Purpose of ReviewHepatorenal syndrome (HRS), the severe manifestation of renal injury in patients with cirrhosis and acute on chronic liver failure...
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APASL clinical practice guidelines on the management of acute kidney injury in acute-on-chronic liver failure
Acute-on-chronic liver failure (ACLF) is a syndrome that is characterized by the rapid development of organ failures predisposing these patients to a...
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Risk stratification based on acute-on-chronic liver failure in cirrhotic patients hospitalized for acute variceal bleeding
Background and aimsAcute variceal bleeding (AVB) is a life-threatening complication of cirrhosis. Acute-on-chronic liver failure (ACLF) is a syndrome...
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Liver transplantation in patients with acute-on-chronic liver failure
Acute-on-chronic liver failure (ACLF) is a dynamic syndrome associated with a very high short-term mortality. Hence, the ongoing assessment of...
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Spur cells in liver cirrhosis are predictive of acute-on-chronic liver failure and liver-related mortality regardless of severe anaemia
Chronic anaemia in advanced liver disease is a frequent finding. The aim was to explore the clinical impact of spur cell anaemia, a rare entity...
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Thrombospondin 1 enhances systemic inflammation and disease severity in acute-on-chronic liver failure
BackgroundThe key role of thrombospondin 1 (THBS1) in the pathogenesis of acute-on-chronic liver failure (ACLF) is unclear. Here, we present a...
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Clinical features and prognosis of acute-on-chronic liver failure in patients with recompensated cirrhosis
BackgroundThere are few studies on acute-on-chronic liver failure (ACLF) in patients with recompensated cirrhosis. This study was aimed to...
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Mixed mode of artificial liver support in patients with acute-on-chronic liver failure: a retrospective cohort study
Background and aimsDifferent modes of artificial liver support (ALS) therapy can improve the survival of patients with acute-on-chronic liver failure...
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Healthcare utilization and outcomes of living donor liver transplantation for patients with APASL-defined acute-on-chronic liver failure
BackgroundLiver transplantation (LT) is associated with excellent survival in patients with acute-on-chronic liver failure (ACLF). There is a lack of...
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Complement C3 Facilitates Stratification of Stages of Chronic Hepatitis B and Signifies Development of Acute-on-Chronic Liver Failure in Acute Decompensated Cirrhosis
IntroductionPatients with chronic hepatitis B (CHB) have a dynamic disease process and risk of end-stage liver disease. It is critical to...
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Acute-on-chronic liver failure alters linezolid pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study
BackgroundIn acute-on-chronic liver failure (ACLF), adequate antibiotic dosing is challenging due to changes of drug distribution and elimination. We...
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Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle
BackgroundAcute-on-chronic liver failure (ACLF) is a refractory disease with high mortality, which is characterized by a pathophysiological process...
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A novel prognostic model to predict mortality in patients with acute-on-chronic liver failure in intensive care unit
Acute-on-chronic liver failure (ACLF) implies high short-term mortality rates and usually requires intensive care unit (ICU) admission. Proper...
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Serum interleukin-6 level predicts the prognosis for patients with alcohol-related acute-on-chronic liver failure
AimHeavy alcohol consumption is the most common etiology of acute-on-chronic liver failure (ACLF) in Japan. In some patients, ACLF is associated with...
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Liver-derived extracellular vesicles from patients with hepatitis B virus-related acute-on-chronic liver failure impair hepatic regeneration by inhibiting on FGFR2 signaling via miR-218-5p
BackgroundImpaired liver regeneration in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) patients is closely related to...
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Evidence for and Against Liver Transplantation for Acute-on-Chronic Liver Failure
Purpose of reviewLiver transplantation for patients with acute-on-chronic liver failure (ACLF) is controversial. This article summarizes recent...
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Downregulated VISTA enhances Th17 differentiation and aggravates inflammation in patients with acute-on-chronic liver failure
Background and aimsPersistent inflammatory response and immune activation are the core mechanisms underlying acute-on-chronic liver failure (ACLF)....
