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Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle
BackgroundAcute-on-chronic liver failure (ACLF) is a refractory disease with high mortality, which is characterized by a pathophysiological process...
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A brief overview of drug-induced liver damage
Drug-induced liver injury (DILI) is a prevalent disorder that can be led on by almost all drug types. The majority of benign DILI cases become better...
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Overview of acute liver failure in India
Acute liver failure (ALF) is an infrequent, but serious complication subsequent to severe acute liver injury (sALI) due to various hepatotoxic agents...
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Living donor liver transplantation for a patient with acute liver failure following thyroid storm: a case report
BackgroundThyroid storm can be complicated by liver dysfunction, which may occasionally progress to acute liver failure. We herein report a case of...
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Acute kidney injury in acute liver failure: A narrative review
Acute kidney injury (AKI) is a frequent complication of acute liver failure (ALF) and it worsens the already worse prognoses of ALF. ALF is an...
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Acute liver failure histopathology: A 5-year retrospective study
BackgroundAcute liver failure (ALF) is a rare, life-threatening disease of diverse etiology. It is defined as severe acute liver injury for fewer...
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Pediatric acute liver failure: Current perspective in etiology and management
Pediatric acute liver failure (PALF) is a catastrophic clinical condition with very high morbidity and mortality without early detection and...
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Pediatric Acute-on-Chronic Liver Failure
Acute-on-chronic liver failure (ACLF) is characterized by an acute hepatic insult happening in a patient with underlying cirrhosis with compromised...
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Acute Kidney Injury in Acute on Chronic Liver Failure Versus Decompensated Cirrhosis—What Is the Difference?
Purpose of ReviewHepatorenal syndrome (HRS), the severe manifestation of renal injury in patients with cirrhosis and acute on chronic liver failure...
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Viral hepatitis–induced acute liver failure
Viral hepatitis–induced acute liver failure (ALF) is a preventable cause for liver-related mortality worldwide. Viruses are the most common cause for...
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APASL clinical practice guidelines on the management of acute kidney injury in acute-on-chronic liver failure
Acute-on-chronic liver failure (ACLF) is a syndrome that is characterized by the rapid development of organ failures predisposing these patients to a...
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Elevated IRF9 raised cell apoptosis and tissue damages through suppressing SIRT1 in hyperlipidemia acute pancreatitis with liver injury
BackgroundHyperlipidemia is a vital etiology of acute pancreatitis (AP), 12 to 20% of which have a history of hyperlipidemia. Multiple organ failure...
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Acute liver failure due to herpes simplex viral hepatitis diagnosed by skin lesions and blood tests: a case report
BackgroundThe incidence of acute liver failure from herpes simplex virus is rare.
Case presentationA 71-year-old Japanese man was diagnosed with...
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Intraoperative kidney replacement therapy in acute liver failure
Paediatric acute liver failure (PALF) is often characterised by its rapidity of onset and potential for significant morbidity and even mortality....
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A case of acute liver failure caused by Budd–Chiari syndrome salvaged by brain-dead donor liver transplantation
A 24-year-old man was admitted to our hospital with abdominal distension. He was found to have acute liver failure and diagnosed with Budd–Chiari...
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Zerumbone ameliorates the inflammatory response and organ damage in severe acute pancreatitis via the ROS/NF-κB pathway
ObjectiveThe aim of the current study was to determine the mechanism by which Zerumbone (ZER) ameliorates inflammation and organ damage in a rat...
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Critical care management of acute liver failure
The management of acute liver failure (ALF) in modern hepatology intensive care units (ICU) has improved patient outcomes. Critical care management...
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Acute liver injury in a non-alcoholic fatty liver disease patient with chloroform exposure: a case report
We report a rare case of acute liver injury by daily exposure to small amounts of chloroform in non-alcoholic fatty liver disease (NAFLD) patient....
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Live donor liver transplantation for pediatric acute liver failure: challenges and outcomes
ObjectiveThis study aimed at studying the challenges and outcomes of live-donor liver transplantation (LDLT) for pediatric acute liver failure (PALF).
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ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity
BackgroundAsialoglycoprotein receptor 1 (ASGR1), primarily expressed on hepatocytes, promotes the clearance and the degradation of glycoproteins,...