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Aberrant expressions of TAM receptors are associated with postoperative recurrence in chronic rhinosinusitis with nasal polyps
ObjectivesTAM receptors (TYRO3, AXL, and MER) play important roles in inflammatory responses, but their effects in chronic rhinosinusitis with nasal...
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Aberrant protein aggregation in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal disease. As its pathological mechanisms are not well understood, there are no efficient therapeutics...
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Severe induction of aberrant DNA methylation by nodular gastritis in adults
BackgroundNodular gastritis (NG) is characterized by marked antral lymphoid follicle formation, and is a strong risk factor for diffuse-type gastric...
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Aberrant phosphorylation of human LRH1 at serine 510 is predictable of hepatocellular carcinoma recurrence
We previously identified the AKT-phosphorylation sites in nuclear receptors and showed that phosphorylation of S379 in mouse retinoic acid γ and S518...
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Aberrant synaptophysin expression in classic Hodgkin lymphoma
BackgroundSynaptophysin is an immunohistochemical marker for neuroendocrine differentiation and is widely used in pathologic diagnosis. Its...
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Programmable synthetic receptors: the next-generation of cell and gene therapies
Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat diseases. However, concerns over the safety and efficacy...
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Aberrant salience correlates with psychotic dimensions in outpatients with schizophrenia spectrum disorders
BackgroundAberrant salience is a well-known construct associated with the development and maintenance of psychotic symptoms in schizophrenia....
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Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits
Temporal lobe epilepsy (TLE), one common type of medically refractory epilepsy, is accompanied with altered adult-born dentate granule cells...
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LC-derived excitatory synaptic transmission to dorsal raphe serotonin neurons is inhibited by activation of alpha2-adrenergic receptors
In the central nervous system, noradrenaline transmission controls the degree to which we are awake, alert, and attentive. Aberrant noradrenaline...
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Map** the aberrant brain functional connectivity in new daily persistent headache: a resting-state functional magnetic resonance imaging study
Background and purposeThe pathogenesis of new daily persistent headache (NDPH) is not fully understood. We aim to map aberrant functional...
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Mechanosensitive receptors in migraine: a systematic review
BackgroundMigraine is a debilitating neurological disorder with pain profile, suggesting exaggerated mechanosensation. Mechanosensitive receptors of...
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Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer’s disease
BackgroundThe identification of pathogenic mutations in Alzheimer’s disease (AD) causal genes led to a better understanding of the pathobiology of...
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Adenosine A2A receptors control generalization of contextual fear in rats
Fear learning is essential to survival, but traumatic events may lead to abnormal fear consolidation and overgeneralization, triggering fear...
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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair
While hypoxic signaling has been shown to play a role in many cellular processes, its role in metabolism-linked extracellular matrix (ECM)...
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Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience
Psychosis in disorders like schizophrenia is commonly associated with aberrant salience and elevated striatal dopamine. However, the underlying...
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GluK1 kainate receptors are necessary for functional maturation of parvalbumin interneurons regulating amygdala circuit function
Parvalbumin expressing interneurons (PV INs) are key players in the local inhibitory circuits and their developmental maturation coincides with the...
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Neuronal hyperexcitability in Alzheimer’s disease: what are the drivers behind this aberrant phenotype?
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder leading to loss of cognitive abilities and ultimately, death. With no cure...
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Activation of multiple Eph receptors on neuronal membranes correlates with the onset of optic neuropathy
BackgroundOptic neuropathy is a major cause of irreversible blindness, yet the molecular determinants that contribute to neuronal demise have not...
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LPA1 receptors in the lateral habenula regulate negative affective states associated with alcohol withdrawal
The role of lysophosphatidic acid (LPA) signaling in psychiatric disorders and drug abuse is significant. LPA receptors are widely expressed in the...
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Aberrant NSG1 Expression Promotes Esophageal Squamous Cell Carcinoma Cell EMT by the Activation of ERK Signaling Pathway
BackgroundNeuron-specific gene family member 1 (NSG1) is a 21 kDa endosomal protein that is specifically expressed in neurons.
AimsThis study was to...
