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Detection of AZF microdeletions and analysis of reproductive hormonal profiles in Hainan men undergoing assisted reproductive technology
BackgroundMale infertility has become a global health problem, and genetic factors are one of the essential causes. Y chromosome microdeletion is the...
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Detection of AZF microdeletions and reproductive hormonal profile analysis of infertile sudanese men pursuing assisted reproductive approaches
BackgroundMale factor is the major contributor in roughly half of infertility cases. Genetic factors account for 10–15% of male infertility....
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Y chromosome polymorphisms contribute to an increased risk of non-obstructive azoospermia: a retrospective study of 32,055 Chinese men
PurposeTo investigate the prevalence of Y chromosome polymorphisms in Chinese men and analyze their associations with male infertility and female...
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Complete or partial loss of the Y chromosome in an unselected cohort of 865 non-vasectomized, azoospermic men
BackgroundStructural abnormalities as well as minor variations of the Y chromosome may cause disorders of sex differentiation or, more frequently,...
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Y chromosome microdeletions in Chinese men with infertility: prevalence, phenotypes, and intracytoplasmic sperm injection outcomes
BackgroundThe incidence of Y chromosome microdeletions varies among men with infertility across regions and ethnicities worldwide. However,...
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AZF deletions in Indian populations: original study and meta-analyses
PurposeTo identify the frequency of Y chromosome microdeletions in Indian populations and to quantitatively estimate the significance of association...
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In silico analysis of microRNA genes in azoospermia factor Y-chromosome microdeletions
PurposeMicrodeletion on Y-chromosome is a well-known genetic cause of infertility in azoospermic and oligozoospermic men. RNA transcripts possess...
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Genetik und männliche Infertilität
In around half of couples affected by infertility, a descriptive diagnosis can be established in the male partner. Genetic analyses can help to...
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Clinical, cytogenomic, and molecular characterization of isodicentric Y-chromosome and prediction of testicular sperm retrieval outcomes in azoospermic and severe oligozoospermic infertile men
PurposeSex chromosome abnormalities are associated with male infertility. The aim of this study was to characterize the clinical, cytogenetic, and...
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Y chromosome structural variation in infertile men detected by targeted next-generation sequencing
PurposeTo provide a validated method to identify copy number variation (CNV) in regions of the Y chromosome of infertile men by next-generation...
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Genetische Diagnostik bei ungewollt kinderlosen Paaren oder wiederholten Fehlgeburten
Approximately 10–15% of all couples have an unfulfilled desire to have children, either due to failure to become pregnant or due to recurrent...
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Molecular characterization of the Yp11.2 region deletion in the Chinese Han population
The Y chromosome is male-specific and is important for spermatogenesis and male fertility. However, the Y chromosome is poorly characterized due to...
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Clinical Analysis of Y Chromosome Microdeletions and Chromosomal Aberrations in 1596 Male Infertility Patients of the Zhuang Ethnic Group in Guangxi
The long arm of the Y chromosome (Yq) contains many amplified and palindromic sequences that are prone to self-reorganization during spermatogenesis,...
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46,XX males with SRY gene translocation: cytogenetics and molecular characterization
PurposeXX male syndrome also known as De la Chapelle syndrome/Testicular Disorder of Sex Development (DSD) is a rare genetic abnormality, identified...
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A Novel Frameshift Microdeletion of the TEX12 Gene Caused Infertility in Two Brothers with Nonobstructive Azoospermia
Male infertility is a growing health problem, which affects approximately 7% of the global male population. Nonobstructive azoospermia (NOA) is one...
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Etiology of Male Infertility: an Update
Spermatogenesis is a complex process of germ cell division and differentiation that involves extensive cross-talk between the develo** germ cells...
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The Relationship Between Chromosomal Polymorphism and Male Reproductive Abnormalities
This study aims to investigate the association between chromosomal polymorphisms and abnormalities in male reproductive health. Within the period...
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The predictive factors of successful sperm retrieval for men with Y chromosome AZFc microdeletion
PurposeTo identify key predictors for successful sperm retrieval in men with AZFc microdeletion.
MethodsTotally, 71 infertile men with confirmed...
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The association of gr/gr deletion in the Y chromosome and impaired spermatogenesis in Bulgarian males: a pilot study
BackgroundThe microdeletions of the Y chromosome are associated with a decreased number of sperm cells in the ejaculate and male infertility. One...
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Consequences of Y chromosome microdeletions beyond male infertility
PurposeThe human Y chromosome plays a central role in sex determination and spermatogenesis. The azoospermia factor (AZF) loci on the Y chromosome...
