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Hyperlipidaemia in diabetes: are there particular considerations for next-generation therapies?
Dyslipidaemias are major cardiovascular risk factors, especially in people with diabetes. In this area, next-generation therapies targeting...
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Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets
Lipid droplet formation is a defining histological feature in clear-cell renal cell carcinoma (ccRCC) but the underlying mechanisms and importance of...
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ACLY inhibitors induce apoptosis and potentiate cytotoxic effects of sorafenib in thyroid cancer cells
PurposeATP-citrate lyase (ACLY) is a critical enzyme at the intersection of glucose and lipid metabolism. ACLY is often upregulated or activated in...
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How Will Our Practice Change After the CLEAR Outcomes Trial?
Purpose of ReviewBempedoic acid is a novel therapeutic agent that is designed to reduce levels of low-density lipoprotein cholesterol (LDL-C). The...
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Bempedoic Acid: for Whom and When
Purpose of ReviewThe aim of creating an orally active non-statin cholesterol-lowering drug was achieved with bempedoic acid, a small linear molecule...
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Primäre Fettstoffwechselstörungen – Stellenwert in aktuellen Dyslipidämieleitlinien und therapeutische Innovationen
According to current guidelines, the selection and intensity of lipid-effective therapies are based on the risk to be treated. The sole clinical...
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Bempedoic Acid: A New Non-statin Drug for the Treatment of Dyslipidemia
Statins are currently the first-line drugs for managing dyslipidemia due to their substantial clinical efficacy in reducing low-density lipoprotein...
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Established and Emerging Lipid-Lowering Drugs for Primary and Secondary Cardiovascular Prevention
Despite treatment with statins, patients with elevated low-density lipoprotein cholesterol (LDL-C) and triglycerides remain at increased risk for...
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The impact of ATP-binding cassette transporters on metabolic diseases
Currently, many people worldwide suffer from metabolic diseases caused by heredity and external factors, such as diet. One of the symptoms of...
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Reduction of High Cholesterol Levels by a Preferably Fixed-Combination Strategy as the First Step in the Treatment of Hypertensive Patients with Hypercholesterolemia and High/Very High Cardiovascular Risk: A Consensus Document by the Italian Society of Hypertension
The primary and secondary prevention strategies of atherosclerotic cardiovascular disease (ASCVD) largely rely on the management of arterial...
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New Strategies for Lowering Low-Density Lipoprotein Cholesterol for Cardiovascular Disease Prevention
Purpose of ReviewThe primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD) relies on optimizing cardiovascular health...
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PRSS37 deficiency leads to impaired energy metabolism in testis and sperm revealed by DIA-based quantitative proteomic analysis
Our previous studies have reported that a putative trypsin-like serine protease, PRSS37, is exclusively expressed in testicular germ cells during...
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The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry
The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid (TCA) cycle that are engaged in epigenetic regulation...
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Metabolism-secretion coupling in glucose-stimulated insulin secretion
Pancreatic β-cells in the islets of Langerhans secrete insulin in response to blood glucose levels. Precise control of the amount of insulin secreted...
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Metabolism Serves as a Bridge Between Cardiomyocytes and Immune Cells in Cardiovascular Diseases
Metabolic disorders of cardiomyocytes play an important role in the progression of various cardiovascular diseases. Metabolic reprogramming can...
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Calcium citrate: from biochemistry and physiology to clinical applications
Adequate daily calcium intake should normally be achieved by dietary sources. Since low calcium diets are quite common in subjects that do not reach...
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Role of Bempedoic Acid in Clinical Practice
Many patients do not achieve optimal low-density lipoprotein cholesterol (LDL-C) levels with statins alone; others are unable to tolerate statin...
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Metabolic adaptations in pressure overload hypertrophic heart
This review article offers a detailed examination of metabolic adaptations in pressure overload hypertrophic hearts, a condition that plays a pivotal...
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HSD17B4 methylation enhances glucose dependence of BT-474 breast cancer cells and increases lapatinib sensitivity
PurposeHER2-positive breast cancer has a high chance of achieving pathological complete response when HSD17B4 , responsible for peroxisomal...
